Advancing In Vivo Research with Precision Models
Fred Hutch Cancer Center’s Mouse Development Lab (MoDeL) produces leading-edge mouse models to drive breakthrough discoveries in fundamental biology and human disease research. Contact us at MoDeL@fredhutch.org.
Areas of Focus
Engineering the Genome of Mice
Using CRISPR-based technologies, the MoDeL team introduces precise genetic modifications in mice, enabling researchers to uncover how mammalian genes maintain health and contribute to disease.
Humanizing the Immune System of Mice
Harnessing human bone marrow, the MoDeL team reconstitutes a functional human immune system in specialized recipient mice, providing detailed insights into human blood and immune function.
Approach and Partnerships
MoDeL partners with Shared Resources’ Genetically Engineered Mouse Model (GEMM) Services to implement robust protocols and methods for the reliable and cost-effective generation of mouse models.
MoDeL’s scientific director and team collaborates with Fred Hutch investigators to design in vivo models that best support their research. These projects are prioritized based on programmatic goals set by our Advisory Board.
Our Team
Anthony Rongvaux, PhD
Scientific Director
Dr. Anthony Rongvaux became the scientific director of MoDeL in February of 2025. He is an immunologist who studies how the immune system recognizes and responds to abnormal cells, like infected cells and cancer cells. His specialty is the innate immune system, the first responder of the body's defenses. Dr. Rongvaux studies the cells, genes and molecules that power innate immune responses using powerful laboratory tools he helped create to faithfully model all aspects of the human immune system. These new experimental models allow the Rongvaux team to manipulate particular aspects of the immune response and study its activities in depth.
Andrea Calvillo
Lily Messinger
Gordon Roble
Cassie Sather
To Be Hired
Our Advisory Board
Bruce Clurman, MD, PhD
Marion Dorer, PhD, MBA
Geoff Hill, MD, FRACP, FRCPA
Andrew McGuire, PhD
Marion Pepper, PhD
Gordon Roble, DVM, MBA
Jhimmy Talbot, PhD