The Acute Effects of Exercise on Breast Cancer Biomarkers (ACE Study) is enrolling women to test the effect of moderate intensity exercise on cancer risk factors such as biomarkers in healthy women. Knowing if exercise significantly alters these biomarkers, could help support guidelines for daily exercise for breast cancer prevention and could indicate that exercise even without weight loss is beneficial.
Contact: Jude Warner, acestudy@fredhutch.org
Researchers are studying a subtype of colorectal cancer (CRC) that develops via the serrated pathway with a goal of determining future prevention strategies and advancing treatment for CRC.
Funding Agency: National Institutes of Health
Contact: Rachel Malen, rmalen@fredhutch.org
Addressing research gaps in the molecular subtypes of breast cancer, we are taking a multidisciplinary approach to study the epidemiology and mutational landscapes of basal-like, luminal A, and luminal B tumors.
Funding Agency: DOD
Contact: Sarah Taylor, sataylor@fredhutch.org
This randomized controlled trial will investigate a 12-week dietary intervention based on the Alternative Healthy Eating Index, examining its effects on pain, quality of life, and inflammatory biomarkers among women with laparoscopically-confirmed endometriosis. The study results will help us identify evidence-based, modifiable, dietary factors that decrease pain and improve quality of life among women with endometriosis.
Funding Agency: National Institutes of Health/NINR
Contact: Kelley Meder, MAppEPID, M.P.H., M.I.P.H., healthyeating@fredhutch.org
Researchers are determining the cost-effectiveness of cord blood vs. haplo matched relatives using clinical information from the Bone Marrow Transplant (BMT) Clinical Trials Network (CTN) and insurance claims data.
Funding Agency: National Institutes of Health
Contact: Jordan Steelquist, jsteelq@fredhutch.org
Scientists identify differences in the bacterial community in tumors for patients with etiologically-distinct subgroups of colorectal cancer, and how those differences relate to survival.
Funding Agency: National Cancer Institute
Contact: Amanda Phipps, aphipps@fredhutch.org
After identifying early detection biomarkers for each of these cancers, we are conducting phase 2 and phase 3 validation studies directed towards clearly defined clinical applications.
Funding Agency: National Cancer Institute
Contact: Chris Li, cili@fredhutch.org
Researchers tested the efficacy and safety of beta-carotene and retinyl palmitate in people at high risk for lung cancer in a randomized, double-blind, placebo-controlled trial. Active follow-up of trial. participants ended on June of 2005; however, the program continues to support the extensive biological repository and ancillary studies that use CARET samples and data.
Contact: Jackie Dahlgren, jdahlgre@fredhutch.org
Using two ovarian cancer case-control studies, scientists are trying to determine why some women develop ovarian tumors and others do not.
Funding Agency: National Cancer Institute
Contact: Holly Harris, hharris@fredhutch.org
Using the Optum Labs/United Healthcare database, investigators review healthcare use patterns of chronic myelogenous leukemia patients treated in the tyrosine kinase inhibitor era.
Funding Agency: American Association for Cancer Research (AACR)
Contact: Nancy Blythe, nblythe@fredhutch.org
Researchers are developing a decision model designed to evaluate the cost effectiveness of multiplex NGS testing vs. usual care. They plan to pair the decision model with information theory to identify the most efficient and impactful study designs.
Funding Agency: Personalized Medicine Coalition
Contact: Jordan Steelquist, jsteelq@fredhutch.org
The goal of the project is to build and enhance community capacity and infrastructure on childhood obesity initiatives in the Lower Yakima Valley, Washington.
Funding Agency: National Institute on Minority Health and Health Disparities
Contact: Sonia Bishop, sbishop@fredhutch.org
Working with biological specimens, medical records and interviews, researchers investigate how genetic, environmental and lifestyle factors effects the incidence of colon and rectal cancers.
Funding Agency: National Institutes of Health
Contact: Rachel Malen, rmalen@fredhuthc.org
COMPASS provides state-of-the-art study coordination, communication and statistical analysis services to scientific investigators participating multi-center studies.
Contact: Jackie Dahlgren, jdahlgre@fredhutch.org
We are currently recruiting about 200 people to participate in our study. We hope that this study may provide information to help with designing a vaccine for Rhinovirus or for other viruses. Rhinoviruses are responsible for causing 30-50% of common colds. Some people report getting a lot of colds each year while others report never getting sick. This study will compare the immune response to the common cold (rhinovirus) between people who feel like they rarely have cold symptoms versus those who have them more often. We hope that by closely following the body’s specific immune responses in someone who has exposure to the common cold, we can better understand which responses may be required for a successful vaccine against the common cold.
To test the effects of in-person and e-communication (e.g., text, email) interventions on improving diet and physical activity among Latina breast cancer survivors.
Funding Agency: National Institutes of Health / National Cancer Institute
Contact: Lisa Levy, llevy@fredhutch
Building on the success of PROSPR I, PROSPR II investigators from a variety of disciplines and institutions are conducting research to improve the screening of cervical, colorectal, and lung cancers.
Funding Agency: National Cancer Institute
Contact: Marty Stiller, mstiller@fredhutch.org
Researchers compare the differences in cost and quality of life when using allogeneic stem cell transplant versus hypomethylating agents for patients aged 50 to 75 with myelodysplastic syndrome.
Funding Agency: National Institutes of Health
Contact: Jordan Steelquist, jsteelq@fredhutch.org
Scientists are determining the efficacy of dexrazoxane (DRZ) in reducing anthracycline-related cardiomyopathy among participants in DRZ phase 3 therapeutic trials.
Funding Agency: National Cancer Institute
Contact: Nancy Blythe, nblythe@fredhitch.org
Using the data from the 12,000 Carotene and Retinol Efficacy Trial (CARET) participants, this study looks at the effects of both diet and dietary supplements, as well as polymorphisms in oxidative stress regulatory genes, on prostate cancer risk.
Funding Agency: National Cancer Institute
Contact: Diana Lowry, dlowry@fredhutch.org
The Data Management and Coordinating Center (DMCC) of the EDRN is jointly operated by Fred Hutch, the University of Washington, the University of Texas MD Anderson Cancer Center and COMPASS. It provides coordination and data management under the direction of the Steering Committee and develops statistical and analytical methods based for the network.
Funding Agency: National Institutes of Health
Contact: Royce Malnik, rmalnik@fredhutch.org
Scientists are comparing the echocardiographic changes in left ventricular function and geometry for survivors of childhood cancer who experienced cardiomyopathy to those of survivors who did not.
Funding Agency: National Cancer Institute
Contact: Nancy Blythe, nblythe@fredhutch.org
Investigators explore microRNAs and their correlation to breast cancer biomarkers, how weight loss affects their relationship to cancer and obesity, and how the genes are expressed in fat tissue.
Funding Agency: Breast Cancer Research Foundation
Contact: Anne McTiernan, amctiern@fredhutch.org
This study builds on the Seattle 5 a Day Worksite Program and studies the effectiveness of interventions designed to maintain the changes companies made with the original project.
Contact: Sonia Bishop, sbishop@fredhutch.org