Projects & Studies

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APPEAL: Exercise intervention in colorectal polyp patients

Public Health Sciences, Epidemiology

Scientists are investigating the efficacy of a moderate exercise program on colon cancer and how exercise may lower risk in humans.

Funding Agency: National Cancer Institute

Contact: Anne McTiernan, amctiern@fredhutch.org

Acute Effects of Exercise on Breast Cancer Biomarkers (ACE) Study

Public Health Sciences, Epidemiology

The Acute Effects of Exercise on Breast Cancer Biomarkers (ACE Study) is enrolling women to test the effect of moderate intensity exercise on cancer risk factors such as biomarkers in healthy women. Knowing if exercise significantly alters these biomarkers, could help support guidelines for daily exercise for breast cancer prevention and could indicate that exercise even without weight loss is beneficial.

Contact: Jude Warner, acestudy@fredhutch.org

Advanced Colorectal Cancer of Serrated Subtype (ACCESS) Study

Public Health Sciences, Cancer Prevention

Researchers are studying a subtype of colorectal cancer (CRC) that develops via the serrated pathway with a goal of determining future prevention strategies and advancing treatment for CRC.

Funding Agency: National Institutes of Health

Contact: Rachel Malen, rmalen@fredhutch.org

Advancing our Understanding of the Etiologies and Mutational Landscapes of Basal-like, Luminal A, and Luminal B Breast Cancer

Public Health Sciences, Epidemiology

Addressing research gaps in the molecular subtypes of breast cancer, researchers are taking a multidisciplinary approach to study the epidemiology and mutational landscapes of basal-like, luminal A, and luminal B tumors.

Funding Agency: DOD

Contact: Sarah Taylor, sataylor@fredhutch.org

Ancillary Cost-Effectiveness Analysis

Public Health Sciences, Cancer Prevention

Researchers are determining the cost-effectiveness of cord blood vs. haplo matched relatives using clinical information from the Bone Marrow Transplant (BMT) Clinical Trials Network (CTN) and insurance claims data.

Funding Agency: National Institutes of Health

Contact: Jordan Steelquist, jsteelq@fredhutch.org

Bacterial Correlates of Colorectal Cancer Subtypes and Survival

Public Health Sciences, Epidemiology

Scientists identify differences in the gut bacterial community in patients with etiologically-distinct subgroups of colorectal cancer, and how those differences relate to survival.

Funding Agency: National Cancer Institute

Contact: Amanda Phipps, aphipps@fredhutch.org

Breast, Colorectal and Ovary Cancer Clinical Validation Center

Public Health Sciences, Epidemiology

After identifying early detection biomarkers for each of these cancers, scientists have organized phase 2 and phase 3 validation studies for clearly defined clinical applications.

Funding Agency: National Cancer Institute

Contact: Chris Li, cili@fredhutch.org

Carotene and Retinol Efficacy Trial (CARET)

Public Health Sciences, Cancer Prevention

Researchers tested the efficacy and safety of beta-carotene and retinyl palmitate in people at high risk for lung cancer in a randomized, double-blind, placebo-controlled trial. Active follow-up of trial. participants ended on June of 2005; however, the program continues to support the extensive biological repository and ancillary studies that use CARET samples and data.

Contact: Jackie Dahlgren, jdahlgre@fredhutch.org

Chronic Myelogenous Leukemia Care in the Tyrosine Kinase Era

Public Health Sciences, Epidemiology

Using the Optum Labs/United Healthcare database, investigators review healthcare use patterns of chronic myelogenous leukemia patients treated in the tyrosine kinase inhibitor era.

Funding Agency: American Association for Cancer Research (AACR)

Contact: Nancy Blythe, nblythe@fredhutch.org

Clinical and Economic Value of Next Generation Sequencing-Based Diagnostic Testing in Cancer Care

Public Health Sciences, Cancer Prevention

Researchers are developing a decision model designed to evaluate the cost effectiveness of multiplex NGS testing vs. usual care. They plan to pair the decision model with information theory to identify the most efficient and impactful study designs.

Funding Agency: Personalized Medicine Coalition

Contact: Jordan Steelquist, jsteelq@fredhutch.org

Collaboration for a Healthy Community (Together We STRIDE)

Public Health Sciences, Cancer Prevention

The goal of the project is to build and enhance community capacity and infrastructure on childhood obesity initatives in the Lower Yakima Valley, Washington.

Funding Agency: National Institute on Minority Health and Health Disparities

Contact: Sonia Bishop, sbishop@fredhutch.org

Colorectal Research in Epidemiology (CORE) Family Studies

Public Health Sciences, Cancer Prevention

Working with biological specimens, medical records and interviews, researchers investigate how genetic, environmental and lifestyle factors effects the incidence of colon and rectal cancers.

Funding Agency: National Institutes of Health

Contact: Rachel Malen, rmalen@fredhuthc.org

Comprehensive Center for the Advancement of Scientific Strategies (COMPASS)

Public Health Sciences, Biostatistics

COMPASS provides state-of-the-art study coordination, communication and statistical analysis services to scientific investigators participating multi-center studies.

Contact: Jackie Dahlgren, jdahlgre@fredhutch.org

Conquer the Common Cold

Vaccine and Infectious Disease Division, Infectious Disease Sciences

We are currently recruiting about 200 people to participate in our study. We hope that this study may provide information to help with designing a vaccine for Rhinovirus or for other viruses. Rhinoviruses are responsible for causing 30-50% of common colds. Some people report getting a lot of colds each year while others report never getting sick. This study will compare the immune response to the common cold (rhinovirus) between people who feel like they rarely have cold symptoms versus those who have them more often. We hope that by closely following the body’s specific immune responses in someone who has exposure to the common cold, we can better understand which responses may be required for a successful vaccine against the common cold.

Cook for Your Life!: Maintaining Diet and Physical Activity

Public Health Sciences, Cancer Prevention

To test the effects of in-person and e-communication (e.g., text, email) interventions on improving diet and physical activity among Latina breast cancer survivors.

Funding Agency: National Institutes of Health / National Cancer Institute

Contact: Lisa Levy, llevy@fredhutch

Cost Effectiveness Analysis of Stem Cell Transplant in Older MDS Patients

Public Health Sciences, Cancer Prevention

Researchers compare the differences in cost and quality of life when using allogeneic stem cell transplant versus hypomethylating agents for patients aged 50 to 75 with myelodysplastic syndrome.

Funding Agency: National Institutes of Health

Contact: Jordan Steelquist, jsteelq@fredhutch.org

DOVE: A case-control study of ovarian cancer

Public Health Sciences, Epidemiology

Using two ovarian cancer case-control studies, scientists are trying to determine why some women develop ovarian tumors and others do not.

Funding Agency: National Cancer Institute

Contact: Holly Harris, hharris@fredhutch.org

Dexrazoxane and Prevention of Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors

Public Health Sciences, Epidemiology

Scientists are determining the efficacy of dexrazoxane (DRZ) in reducing anthracycline-related cardiomyopathy among participants in DRZ phase 3 therapeutic trials.

Funding Agency: National Cancer Institute

Contact: Nancy Blythe, nblythe@fredhitch.org

Diet and Genetic Risk for Prostate Cancer

Public Health Sciences, Cancer Prevention

Using the data from the 12,000 Carotene and Retinol Efficacy Trial (CARET) participants, this study looks at the effects of both diet and dietary supplements, as well as polymorphisms in oxidative stress regulatory genes, on prostate cancer risk.

Funding Agency: National Cancer Institute

Contact: Diana Lowry, dlowry@fredhutch.org

Early Detection Research Network (EDRN)

Public Health Sciences, Cancer Prevention

The Data Management and Coordinating Center (DMCC) of the EDRN is jointly operated by Fred Hutch, the University of Washington, the University of Texas MD Anderson Cancer Center and COMPASS. It provides coordination and data management under the direction of the Steering Committee and develops statistical and analytical methods based for the network.

Funding Agency: National Institutes of Health

Contact: Royce Malnik, rmalnik@fredhutch.org

Echocardiographic Change in Cancer Survivors at Risk for Cardiomyopathy

Public Health Sciences, Epidemiology

Scientists are comparing the echocardiographic changes in left ventricular function and geometry for survivors of childhood cancer who experienced cardiomyopathy to those of survivors who did not.

Funding Agency: National Cancer Institute

Contact: Nancy Blythe, nblythe@fredhutch.org

Effect of Weight Loss and Exercise on Biomarkers of Breast Cancer Risk

Public Health Sciences, Epidemiology

Investigators explore microRNAs and their correlation to breast cancer biomarkers, how weight loss affects their relationship to cancer and obesity, and how the genes are expressed in fat tissue.

Funding Agency: Breast Cancer Research Foundation

Contact: Anne McTiernan, amctiern@fredhutch.org

Enhancing And Teaching [EAT] 5 for Life Project

Public Health Sciences, Cancer Prevention

This study builds on the Seattle 5 a Day Worksite Program and studies the effectiveness of interventions designed to maintain the changes companies made with the original project.

Contact: Sonja Bishop, sbishop@fredhutch.org

Epidemiology of HPV-related SCC in Transplant Patients

Public Health Sciences, Epidemiology

Using the same baseline cohort, scientists investigate the role of HPV in renal and cardiac organ transplant recipients in two complementary population-based studies.

Funding Agency: National Cancer Institute

Contact: Margaret Madeleine, mmadelei@fredhutch.org

Last Modified, August 08, 2019