Research interests include early innate immune responses to HIV vaccines on subsequent adaptive immune responses and systems biology analyses of how immune responses are shaped
Research interests include sexual risk taking, victimization and alcohol/drug abuse among African-American women, HIV prevention for African American and African-born populations and health disparities.
Clinical trial data management, Logistics, operations and study facilitation, Scientific communications, Host-pathogen interactions High-dimensional data analysis
Research interests include targeting latent viral genomes for mutagenesis and disruption of viral pathogenesis and infection using engineered homing endonucleases.
Co-infections impact clinical, virological, and immunologic outcomes in HIV. I work on understanding how we can better treat patients to prevent HIV and HIV-associated complications, including focus on HIV persistence and HIV-associated malignancies.
Mathematical modeling of virus and immune system dynamics. Population/within-host dynamics approach to quantify HIV-1 infection and treatment efficacy (ordinary differential equations, nonlinear mixed effects models).
Characterization of immunological “signature” associated with development of cross-neutralizing antibody responses in HIV-infected individuals.
Immune profiling of cancer immunotherapy clinical trial subjects to further the understanding of therapy-driven patient immune responses in order to develop more effective cancer treatments.
Interests include supervised learning methods in infectious disease modeling, semiparametrics and Bayesian assessment of complex models
Correlates analysis, sieve analysis and antigenic mapping focusing on HIV-1 vaccines and immunology
Research interests include mathematical modeling of infectious diseases, evaluating impact of interventions for HIV prevention, mathematical biology (population dynamics, epidemic modeling) and dynamical systems (ODE, PDE, and impulsive systems)
Oversight for quality control of Good Clinical Lab Practice (GCLP)-compliant assays and is studying cellular immune responses to HIV vaccines for the Cape Town HVTN laboratory. Research involves interrogation of the phenotype and transcriptional profile of vaccine induced T cells in order to better understand these T cell responses.
Design and analysis of trials for HIV prevention, methods for meta-analysis of clinical trials, Bayesian approaches for extrapolation of efficacy between populations.
Statistical and computational methods for bioinformatics applications, statistical modeling for genome sequence analysis and statistical modeling frameworks. The interface between computer science, statistics, and molecular biologyand such as development of new informatics methods in genomics and post-genomics
Clinical trial design and operations, good clinical data management practices (GCDMP), research regulations, behavioral research methodology, research ethics
Current studies include development of methods for T-cell based sieve analysis, quantification of vaccine induced T cell responses, systems biology of influenza and time-dependent correlates analysis of HIV efficacy trial.
HVTN cross-protocol analyses
Immune monitoring and correlative science analyses for early clinical trials in the area of cancer immunotherapy.
Roles of regulatory T cells in modulating anti-viral immunity, understanding the host immune response in anti-viral immunity and vaccine development
Immunology and vaccine design for development of vaccines, especially HIV-1 vaccine
Design and analytic methods for HIV prevention trials and measurement-error modeling and bias correction
Immunologic endpoint determination for experimental vaccines (HIV, pneumococcus, malaria, TB, flu) and Logistics, operations, quality assurance, and assay validation for immunologic evaluation of vaccines in the clinical trial setting
Design and analysis of vaccine efficacy trials, genotype-specific vaccine efficacy-based sieve analysis,immune correlates of vaccine protection, analysis of vaccine-induced immune response durability and survival analysis
HIV vaccine development and trial design, combination HIV prevention, mucosal immunology and mucosal sampling design in HIV prevention trials, the intersection of oncology and infectious disease, comparative effectiveness, decision analysis and health-related quality of life
Research focus includes the study the barrier and immune mechanisms that contribute to protection after circumcision, vaccine or passive immunizations at mucosal sites of encounter with HIV
Development of genetic statistical methodologies, including phylogenetic tree reconstruction from genetic sequences
Research lies at the interface of mathematics, computer science, biology, and public health policy. I utilize and develop quantitative tools including dynamical systems, differential equations, stochastic processes, operations research and optimization to understand complex biological processes.
Research interests include analysis of immune response to vaccine candidates, study design for pilot studies, statistical methods for biological assays, and infectious disease models.
Research focus includes the role of the microbiome in human health and disease.
Research focus includes design and analysis of vaccine clinical trials, immune correlates of risk and protection, statistical training and capacity building.
Research focus includes HIV clinical trial design and conduct; complications of antiretroviral therapy and HIV-associated malignancies
Research focus includes preclinical animal models for vaccines and adjuvants testing, vaccine product development and clinical trial design, vaccine adjuvants, formulations and innate immune responses, immunological evaluation of vaccines and project management for collaborative research projects
Research focus includes the analysis of humoral immune response to HSV-2 and its vaccine candidates and understanding the role of tissue B cells in HSV-2 infection
Research interests include the design and analysis of group-sequential and complex clinical trials, specifically as pertaining to HIV prevention trials.
Research focus includes ecology of human microbial communities, impact of bacterial interactions on health and disease, molecular diagnosis of bacterial pathogens and bacterial adaptive responses
Research focus includes development of DNA editing enzymes that target the genomes of viruses that undergo latent infections and viral vectors for gene delivery to sites of latent viral infection
Research commitment, inquiry, and interests are situated at the intersection of public health and social justice to further understand and mitigate the impacts of structural and social factors like stigma, racism, sexism, homophobia/transphobia, historical trauma, and education and income inequities on population-level health. Particularly interested in the health and wellbeing of Black and LGBTQ populations.
Research is focused on statistical analysis of survey data, Bayesian modeling including Bayesian nonparametrics and the design and analysis of vaccine studies
Statistical methods in HIV/AIDS research and monitoring and analyzing drug adherence patterns. Transmission models for infectious disease epidemiology.