The Biostatistics, Bioinformatics and Epidemiology Program (BBE) supplies the statistical and mathematical modeling expertise needed within Fred Hutch’s Vaccine and Infectious Disease Division to accomplish our ambitious objective of eliminating disease and death attributable to infection. We are also accelerating research to confront the growing burden of HIV and cancer-related infectious diseases worldwide.
BBE's 41 faculty members model epidemics, research statistical methods to design complex global clinical trials, and analyze biological assays to better understand infectious disease processes and immune responses.
A hallmark of BBE is the simultaneous pursuit of excellence in both methodological and applied science. Researchers frequently develop novel mathematical approaches to better answer scientific questions that continually emerge from ongoing studies within the division.
Faculty and Labs
BBE faculty members are experts in five key quantitative disciplines: biostatistics, bioinformatics, computational biology, infectious disease epidemiology and mathematical modeling.
News
See the latest news about our program scientists, research, grants and discoveries.
Networks and Collaborations
Fred Hutch serves as the statistical and data management center for several international collaborative studies aiming to develop safe, effective vaccines, preventions, and therapies to combat HIV/AIDS. BBE faculty members contribute critical expertise to these networks. This includes designing experimental protocols, innovating statistical methods for data analysis and analyzing and interpreting study data.
HIV Vaccine Trials Network (HVTN)
BBE faculty member Peter Gilbert leads HVTN’s Statistical Data Management Center. Funded by the National Institutes of Health, HVTN oversees worldwide clinical trials to test vaccines against HIV/AIDS. The network designs and conducts all phases of clinical trials, from evaluating experimental vaccines for safety and immunogenicity to testing vaccine efficacy.
HIV Prevention Trials Network (HPTN)
BBE faculty member Deborah Donnell leads HPTN’s Statistical Data Management Center, and SCHARP is employed to supply clinical data management and statistical service support. Founded in 2000, HPTN researches integrated strategies for HIV prevention, including antiretroviral drugs and behavioral interventions.
Vaccine Immunology Statistical Center (VISC)
BBE faculty member Ollivier Hyrien leads VISC, a Gates Foundation-funded program that provides statistics support for the Foundation’s HIV vaccine development initiative, Collaboration for AIDS Vaccine Discovery (CAVD). The BBE statisticians in VISC have expertise in the areas of biostatistics, immunologic assays, bioinformatics, data management, and information systems. VISC also partners with SCHARP for management of lab data and other critical operational support.
Major Research Efforts
Fred Hutch directs major worldwide, multicenter studies to model the spread of infectious diseases and to combat the global HIV/AIDS epidemic. Our biostatisticians play leadership roles in these initiatives.
SCHARP is a world-class statistical and data center dedicated to improving global health. SCHARP’s biostatisticians, programmers, and data management experts manage clinical and laboratory data and support statistical design and analysis of clinical trials. Experts in regulatory compliance, SCHARP handles all regulatory and reporting requirements according to international standards. SCHARP is the Statistical and Data Management Center for multiple global HIV research networks and supports the design, data management and analysis of other infectious disease and oncology clinical trials at Fred Hutch.
Featured Lab: Predicting Epidemics Before they Start
Evolutionary biologist Trevor Bedford uses complex statistical and computational methodology to study the rapid spread and evolution of viruses, from Influenza to Zika. The goal is to disrupt global epidemics before they spread.
Our Leadership
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Holly Janes, PhD
Dr. Holly Janes is a biostatistician working on the design and analysis of vaccine studies, with a particular expertise in HIV prevention and vaccine science. She also develops and applies statistical methodology for evaluating biomarkers for risk prediction and optimizing treatment decisions.
Ollivier Hyrien, PhD
Dr. Ollivier Hyrien is a biostatistician who applies advanced technologies such as machine learning and dynamic modeling to address problems in laboratory experiments and clinical studies. His research focuses on statistical methods for flow cytometry, single-cell sequencing and other bioassays.
Contact
BBE Administration
BBE Executive Assistants
BBE Admin General
(Youyi Fong, Ying Huang, JT McCrone, Fei Gao, Aaron Hudson, and Bo Zhang)