The Molecular Design and Therapeutics lab offers protein engineering and expression support for local investigators. Our focus is on delivering preclinical quantities of endotoxin-free protein and providing all the expertise needed for the design of novel biologics.
Since each protein expression project is unique we will help tailor expression strategies to the unique needs of the investigator. We have all the expertise available to assist investigators in designing expression constructs that maximize success.
The Molecular Design and Therapeutics support lab has one Agilent 1260 HPLC equipped with in-line degasser, diode array detector, fluorescence detector and single quadrupole MS. It is capable of fractionating samples for a variety of applications on a semi-preparative scale.
The Molecular Design and Therapeutics support lab has one Labconco -105°C 4.5 liter freeze dry system.
The Molecular Design and Therapeutics core lab has two ÄKTA pure 25 L systems for routine affinity chromatography and one ÄKTA pure 25 M (with multiple wavelength monitoring). Each ÄKTA system is equipped with an external system pump and fraction collector. We also have most chromatography columns used for routine protein separations.
The Molecular Design and Therapeutics support lab has six Infors HT Multitron shaking incubators capable of handling over 60 liters of suspension culture at one time. We routinely grow Freestyle 293-F cells.