Advancing Research in Stem Cell and Transplantation Biology
Fred Hutch's Co-Operative Center for Excellence in Hematology (CCEH) is a National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) funded hematology center. Fred Hutch's CCEH programs consists of an administrative core and labs the provide a number of services to advance research in stem-cell and transplantation biology. Additional information about all the CCEH Centers can be found at the CCEH Program’s website (cceh.io).
Administrative CORE
The Administrative Core provides scientific and budgetary oversight for all CCEH activities. This includes oversight of the Enrichment Programs which supports: the Pilot and Feasibility program grants, hosting outside speakers, the Summer High School internship Program (SHIP), and the Alexandria Real Estate Equities, Inc. Learning Lab which hosts guests/students for a few hours to a few days for campus tours and hands on lab activities. The Alexandria Learning Lab is unique in that it has met Fred Hutch and Washington state regulations to be approved for minors to participate in simulated lab activities. We also welcome NIDDK-funded trainees from anywhere in the U.S to visit for short-term on-sight training opportunities with our Core Resource laboratories.
CCEH Grants and Education Programs
Pilot & Feasibility Program Grants
Educational Enrichment Opportunities
Pilot & Feasibility Program Grants
The Pilot and Feasibility Studies Program, funded by the U24 NIDDK CCEH grant, supports two grant mechanisms to advance benign hematology research. Type A awards provide core credits up to $12,000 for resources from one of the many CCEH cores at five Centers (Cincinnati Children’s, Fred Hutch, Indiana University, University of Utah, and Yale). Type B awards provide pilot funds up to $75,000, use of CCEH Core resources is not required but encouraged. The Pilot and Feasibility Program aims to be a steppingstone for junior investigators to fund small projects to generate preliminary data for inclusion in larger grant applications.
If you would like more information, contact the Enrichment Core administrator, Lori Blake at 206.667.4523 or lblake@fredhutch.org. Additional information can also be found on the main CCEH funding page.
CCEH Research Services at Fred Hutch
The CCEH offer unique resources and established hematology expertise through scientific cores on a fee-for-service basis.
Hematopoietic Cell Procurement & Processing
Hematopoietic Cell Procurement and Processing is recognized as a leader in the field of acquisition, analysis, and enrichment of normal hematopoietic cells, this facility provides well defined and highly purified populations of cells to support the research of both internal and external investigators.
Cell & Molecular Services/Analysis Lab
The Cell and Molecular Services and Analysis lab provides VNTR (Variable Number Tandem Repeat), and LAM-PCR (Linear Amplification Mediated PCR) and other molecular technology to analyze genotypes.
Cell Manipulation Tools
The Cell Manipulation Tools Core offers a range of solutions, providing tools to silence or introduce genes of interest into cells. We offer both CRISPR-Cas9 based genome editing as well as full service viral preparation services.
Additional scientific resources for investigators
CCEH Administrative CORE Leadership
Derek Stirewalt, MD
Dr. Derek Stirewalt studies the basic changes that occur in our blood stem cells as we age and their role in leukemia and other diseases. He uses cutting-edge technology to examine DNA, RNA and wide swaths of proteins to find new molecular calling cards as these diseases develop.
Dr. Stirewalt’s clinical expertise lies within the evaluation and treatment of patients with hematopoietic malignancies, with a particular interest in those patients with leukemia. He has been an active member of Fred Hutch’s transplant program for over 20 years and routinely oversees the care of patients receiving either an autologous or allogeneic transplant.
Christina Termini, PhD
Assistant Director Center of Excellence in Hematology
Dr. Termini studies the fundamental processes that coordinate hematopoietic cell functions during homeostasis, stress, and disease, with a particular emphasis on the role of glycoproteins in these processes. The Termini Lab focuses on the intrinsic and extrinsic cues that support the maintenance and regeneration of the hematopoietic system after radiation and chemotherapy.
She is currently an Assistant Professor in the Translational Science and Therapeutics Division and an affiliate of the Human Biology Division at Fred Hutch. In addition to her research program, she has led numerous mentoring initiatives and campaigns to promote inclusivity in research environments, including the Dr. Eddie Mendèz Post-Doctoral Research Symposium and the recently launched Atlas of Inspiring Hispanic/Latinx Scientists.