Fred Hutch, Seattle Cancer Care Alliance, and UW Medicine Complete Restructure of Partnership

Learn More

Scientific Publications

Select Recent Publications

Wu Y, Zeng J, Roscoe BP, Liu P, Yao Q, Lazzarotto CR, Clement K, Cole MA, Luk K, Baricordi C, Shen AH, Ren C, Esrick EB, Manis JP, Dorfman DM, Williams DA, Biffi A, Brugnara C, Biasco L, Brendel C, Pinello L, Tsai SQ, Wolfe SA, Bauer DE. Highly efficient therapeutic gene editing of human hematopoietic stem cells. Nat Med. 2019;25(5):776-83. doi: 10.1038/s41591-019-0401-y. PubMed PMID: 30911135; PMCID: PMC6512986.

Shahbazi R, Sghia-Hughes G, Reid JL, Kubek S, Haworth KG, Humbert O, Kiem HP, Adair JE. Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations. Nat Materials. 2019 Oct;18(10):1124-1132. doi: 10.1038/s41563-019-0385-5. Epub 2019 May 27. PMID: 31133730; PMCID: PMC6754292.

Parker MH, Stone D, Abrams K, Johnson M, Granot N, Storb R. Anti-ICOS mAb Targets Pathogenic IL-17A-expressing Cells in Canine Model of Chronic GVHD. Transplantation. 2021 May 1;105(5):1008-1016. doi: 10.1097/TP.0000000000003489. PMID: 33065723; PMCID: PMC8046842.

Nakaya A, Qiu H, Santos EB, Hamlin DK, Wilbur DS, Storb R, Sandmaier BM. Addition of Astatine-211-Labeled Anti-CD45 Antibody to TBI as Conditioning for DLA-Identical Marrow Transplantation: A Novel Strategy to Overcome Graft Rejection in a Canine Presensitization Model: "Radioimmunotherapy to Overcome Transfusion-Induced Sensitization". Transplant Cell Ther. 2021 Jun;27(6):476.e1-476.e7. doi: 10.1016/j.jtct.2021.02.018. Epub 2021 Feb 25. PMID: 33775618; PMCID: PMC8217096.

Additional Publications Using Resources

2015

Bleakley M, Heimfeld S, Loeb KR, Jones LA, Chaney C, Seropian S, Gooley TA, Sommermeyer F, Riddell SR, Shlomchik WD. Outcomes of acute leukemia patients transplanted with naive T cell-depleted stem cell grafts. Journal of Clinical Investigation. 2015;125(7):2677-89. PubMed PMID: 26053664; PMCID: PMC4563691.

McCune JS, Mager DE, Bemer MJ, Sandmaier BM, Storer BE, Heimfeld S. Association of fludarabine pharmacokinetic/dynamic biomarkers with donor chimerism in nonmyeloablative HCT recipients. Cancer Chemotherapy and Pharmacology. 2015;76(1):85-96. doi: 10.1007/s00280-014-2768-x. PubMed PMID: 25983023; PMCID: PMC4489995.

Roadmap Epigenomics Consortium, Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, Kheradpour P, Zhang Z, Wang J, Ziller MJ, Amin V, Whitaker JW, Schultz MD, Ward LD, Sarkar A, Quon G, Sandstrom RS, Eaton ML, Wu YC, Pfenning AR, Wang X, Claussnitzer M, Liu Y, Coarfa C, Harris RA, Shoresh N, Epstein CB, Gjoneska E, Leung D, Xie W, Hawkins RD, Lister R, Hong C, Gascard P, Mungall AJ, Moore R, Chuah E, Tam A, Canfield TK, Hansen RS, Kaul R, Sabo PJ, Bansal MS, Carles A, Dixon JR, Farh KH, Feizi S, Karlic R, Kim AR, Kulkarni A, Li D, Lowdon R, Elliott G, Mercer TR, Neph SJ, Onuchic V, Polak P, Rajagopal N, Ray P, Sallari RC, Siebenthall KT, Sinnott-Armstrong NA, Stevens M, Thurman RE, Wu J, Zhang B, Zhou X, Beaudet AE, Boyer LA, De Jager PL, Farnham PJ, Fisher SJ, Haussler D, Jones SJ, Li W, Marra MA, McManus MT, Sunyaev S, Thomson JA, Tlsty TD, Tsai LH, Wang W, Waterland RA, Zhang MQ, Chadwick LH, Bernstein BE, Costello JF, Ecker JR, Hirst M, Meissner A, Milosavljevic A, Ren B, Stamatoyannopoulos JA, Wang T, Kellis M. Integrative analysis of 111 reference human epigenomes. Nature. 2015;518(7539):317-30. Epub 2015/02/20. doi: 10.1038/nature14248. PubMed PMID: 25693563; PMCID: PMC4530010.

Rosinski SL, Stone B, Graves SS, Fuller DH, De Rosa SC, Spies GA, Mize GJ, Fuller JT, Storb R. Development of a minor histocompatibility antigen vaccine regimen in the canine model of hematopoietic cell transplantation. Transplantation. 2015;99(10):2083-94. doi: 10.1097/TO.0000000000000744. PubMed PMID: 25965411; PMCID: PMC4591091.

2016

Adair JE, Waters T, Haworth KG, Kubek SP, Trobridge GD, Hocum JD, Heimfeld S, Kiem HP. Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy. Nat Commun. 2016;7:13173. Epub 2016/10/21. doi: 10.1038/ncomms13173. PubMed PMID: 27762266; PMCID: PMC5080442.

Aranda-Orgilles B, Saldana-Meyer R, Wang E, Trompouki E, Fassl A, Lau S, Mullenders J, Rocha PP, Raviram R, Guillamot M, Sanchez-Diaz M, Wang K, Kayembe C, Zhang N, Amoasii L, Choudhuri A, Skok JA, Schober M, Reinberg D, Sicinski P, Schrewe H, Tsirigos A, Zon LI, Aifantis I. MED12 Regulates HSC-Specific Enhancers Independently of Mediator Kinase Activity to Control Hematopoiesis. Cell Stem Cell. 2016;19(6):784-99. Epub 2016/08/30. doi: 10.1016/j.stem.2016.08.004. PubMed PMID: 27570068; PMCID: PMC5268820.

Conerly ML, Yao Z, Zhong JW, Groudine M, Tapscott SJ. Distinct activities of Myf5 and MyoD indicate separate roles in skeletal muscle lineage specification and differentiation. Developmental Cell. 2016;36(4):375-85. PubMed PMID: 26906734; PMCID: PMCID: PMC4769793.

Gallo S, Woolfrey AE, Burroughs LM, Storer BE, Flowers ME, Hari P, Pulsipher MA, Heimfeld S, Kiem HP, Sandmaier BM, Storb R. Marrow grafts from HLA-identical siblings for severe aplastic anemia: does limiting the number of transplanted marrow cells reduce the risk of chronic GVHD? Bone Marrow Transplant. 2016;51(12):1573-8. doi: 10.1038/bmt.2016.198. PubMed PMID: 27479689; PMCID: PMC5143192.

Humbert O, Gisch DW, Wohlfahrt ME, Adams AB, Greenberg PD, Schmitt TM, Trobridge GD, Kiem HP. Development of third-generation cocal envelope producer cell lines for robust lentiviral gene transfer into hematopoietic stem cells and T-cells. Mol Ther. 2016;24(7):1237-46. doi: 10.1038/mt.2016.70. PubMed PMID: 27058824; PMCID: PMC5088759.

Liu L, Sommermeyer D, Cabanov A, Kosasih P, Hill T, Riddell SR. Inclusion of Strep-tag II in design of antigen receptors for T-cell immunotherapy. Nat Biotechnol. 2016;34(4):430-4. Epub 2016/02/24. doi: 10.1038/nbt.3461. PubMed PMID: 26900664; PMCID: PMC4940167.

Richter M, Saydaminova K, Yumul R, Krishnan R, Liu J, Nagy EE, Singh M, Izsvak Z, Cattaneo R, Uckert W, Palmer D, Ng P, Haworth KG, Kiem HP, Ehrhardt A, Papayannopoulou T, Lieber A. In vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectors. Blood. 2016;128(18):2206-17. doi: 10.1182/blood-2016-04-711580. PubMed PMID: 27554082; PMCID: PMC5095755.

Rosinski SL, Stone B, Graves SS, Fuller DH, Fuller JT, Storb R. Minor antigen vaccine-sensitized DLI: in vitro responses do not predict in vivo effects. Transplantation Direct. 2016;2(5):e71. doi: 10.1097/TXD.0000000000000583. PubMed PMID: 27430015; PMCID: PMC4943762.

Rufener GA, Press OW, Olsen P, Lee SY, Jensen MC, Gopal AK, Pender B, Budde LE, Rossow JK, Green DJ, Maloney DG, Riddell SR, Till BG. Preserved activity of CD20-specific chimeric antigen receptor-expressing T cells in the presence of rituximab. Cancer immunology research. 2016;4(6):509-19. Epub 2016/04/21. doi: 10.1158/2326-6066.CIR-15-0276. PubMed PMID: 27197068; PMCID: PMC4891234.

Turtle CJ, Hanafi LA, Berger C, Gooley TA, Cherian S, Hudecek M, Sommermeyer D, Melville K, Pender B, Budiarto TM, Robinson E, Steevens NN, Chaney C, Soma L, Chen X, Yeung C, Wood B, Li D, Cao J, Heimfeld S, Jensen MC, Riddell SR, Maloney DG. CD19 CAR-T cells of defined CD4+:CD8+ composition in adult B cell ALL patients. J Clin Invest. 2016;126(6):2123-38. doi: 10.1172/JCI85309. PubMed PMID: 27111235; PMCID: PMC4887159.

2017

Belay E, Hayes BJ, Blau CA, Torok-Storb B. Human cord blood and bone marrow CD34+ cells generate macrophages that support erythroid islands. PLoS One. 2017;12(1):e0171096. Epub 2017/01/31. doi: 10.1371/journal.pone.0171096. PubMed PMID: 28135323; PMCID: PMC5279789.

Canver MC, Lessard S, Pinello L, Wu Y, Ilboudo Y, Stern EN, Needleman AJ, Galacteros F, Brugnara C, Kutlar A, McKenzie C, Reid M, Chen DD, Das PP, M AC, Zeng J, Kurita R, Nakamura Y, Yuan GC, Lettre G, Bauer DE, Orkin SH. Variant-aware saturating mutagenesis using multiple Cas9 nucleases identifies regulatory elements at trait-associated loci. Nat Genet. 2017;49(4):625-34. Epub 2017/02/22. doi: 10.1038/ng.3793. PubMed PMID: 28218758; PMCID: PMC5374001.

Elagib KE, Lu CH, Mosoyan G, Khalil S, Zasadzinska E, Foltz DR, Balogh P, Gru AA, Fuchs DA, Rimsza LM, Verhoeyen E, Sanso M, Fisher RP, Iancu-Rubin C, Goldfarb AN. Neonatal expression of RNA-binding protein IGF2BP3 regulates the human fetal-adult megakaryocyte transition. J Clin Invest. 2017. Epub 2017/05/10. doi: 10.1172/jci88936. PubMed PMID: 28481226; PMCID: PMC Journal - In Process.

Gilles L, Arslan AD, Marinaccio C, Wen QJ, Arya P, McNulty M, Yang Q, Zhao JC, Konstantinoff K, Lasho T, Pardanani A, Stein B, Plo I, Sundaravel S, Wickrema A, Migliaccio A, Gurbuxani S, Vainchenker W, Platanias LC, Tefferi A, Crispino JD. Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis. J Clin Invest. 2017;127(4):1316-20. Epub 2017/02/28. doi: 10.1172/jci82905. PubMed PMID: 28240607; PMCID: PMC5373858.

Gornalusse GG, Hirata RK, Funk SE, Riolobos L, Lopes VS, Manske G, Prunkard D, Colunga AG, Hanafi LA, Clegg DO, Turtle C, Russell DW. HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells. Nat Biotechnol. 2017;35(8):765-72. doi: 10.1038/nbt.3860. PubMed PMID: 28504668; PMCID: PMC5548598.

Graves SS, Rezvani A, Sale G, Stone D, Parker M, Rosinski S, Spector M, Swearingen B, Kean L, Storb R. A canine model of chronic graft-vs.-host disease. Biol Blood Marrow Transplant. 2017;23(3):420-7. doi: 10.1016/j.bbmt.2016.12.629. PubMed PMID: 28013013; PMCID: PMC5304921.

Hale M, Lee B, Honaker Y, Leung WH, Grier AE, Jacobs HM, Sommer K, Sahni J, Jackson SW, Scharenberg AM, Astrakhan A, Rawlings DJ. Homology-directed recombination for enhanced engineering of chimeric antigen receptor T cells. Mol Ther Methods Clin Dev. 2017;4:192-203. doi: 10.1016/j.omtm.2016.12.008. PubMed PMID: 28345004; PMCID: PMC5363294.

Hale M, Mesojednik T, Romano Ibarra GS, Sahni J, Bernard A, Sommer K, Scharenberg AM, Rawlings DJ, Wagner TA. Engineering HIV-resistant, anti-HIV chimeric antigen receptor T cells. Mol Ther. 2017;25(3):570-9. doi: 10.1016/j.ymthe.2016.12.023. PubMed PMID: 28143740; PMCID: PMC5363191.

Li J, Nicoud I, Blake J, Oliver D, Cox E, Heimfeld S, Milano F, Imren S, Delaney C. Real Time Immunophenotyping of Leukocyte Subsets Early after Double Cord Blood Transplantation Predicts Graft Function. Biol Blood Marrow Transplant. 2017;23(3):412-9. Epub 2016/12/23. doi: 10.1016/j.bbmt.2016.12.625. PubMed PMID: 28007666; PMCID: PMC5348257.

Moffett HF, Coon ME, Radtke S, Stephan SB, McKnight L, Lambert A, Stoddard BL, Kiem HP, Stephan MT. Hit-and-run programming of therapeutic cytoreagents using mRNA nanocarriers. Nat Commun. 2017;8(1):389. Epub 2017/09/01. doi: 10.1038/s41467-017-00505-8. PubMed PMID: 28855514; PMCID: PMC5577173.

Sim X, Jarocha D, Hayes V, Hanby HA, Marks MS, Camire RM, French DL, Poncz M, Gadue P. Identifying and enriching the platelet-producing human stem cell-derived megakaryocytes using factor V uptake. Blood. 2017. Epub 2017/04/30. doi: 10.1182/blood-2017-01-761049. PubMed PMID: 28455282; PMCID: PMC Journal - In Process.

Tothova Z, Krill-Burger JM, Popova KD, Landers CC, Sievers QL, Yudovich D, Belizaire R, Aster JC, Morgan EA, Tsherniak A, Ebert BL. Multiplex CRISPR/Cas9-based genome editing in human hematopoietic stem cells models clonal hematopoiesis and myeloid neoplasia. Cell Stem Cell. 2017;21(4):547-55 e8. doi: 10.1016/j.stem.2017.07.015. PubMed PMID: 28985529; PMCID: PMC5679060.

van Rooij FJ, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang LC, Schmidt H, Yang ML, Chen MH, Hayes J, Johnson AD, Yanek LR, Mueller C, Lange L, Floyd JS, Ghanbari M, Zonderman AB, Jukema JW, Hofman A, van Duijn CM, Desch KC, Saba Y, Ozel AB, Snively BM, Wu JY, Schmidt R, Fornage M, Klein RJ, Fox CS, Matsuda K, Kamatani N, Wild PS, Stott DJ, Ford I, Slagboom PE, Yang J, Chu AY, Lambert AJ, Uitterlinden AG, Franco OH, Hofer E, Ginsburg D, Hu B, Keating B, Schick UM, Brody JA, Li JZ, Chen Z, Zeller T, Guralnik JM, Chasman DI, Peters LL, Kubo M, Becker DM, Li J, Eiriksdottir G, Rotter JI, Levy D, Grossmann V, Patel KV, Chen CH, Ridker PM, Tang H, Launer LJ, Rice KM, Li-Gao R, Ferrucci L, Evans MK, Choudhuri A, Trompouki E, Abraham BJ, Yang S, Takahashi A, Kamatani Y, Kooperberg C, Harris TB, Jee SH, Coresh J, Tsai FJ, Longo DL, Chen YT, Felix JF, Yang Q, Psaty BM, Boerwinkle E, Becker LC, Mook-Kanamori DO, Wilson JG, Gudnason V, O'Donnell CJ, Dehghan A, Cupples LA, Nalls MA, Morris AP, Okada Y, Reiner AP, Zon LI, Ganesh SK. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017;100(1):51-63. Epub 2016/12/27. doi: 10.1016/j.ajhg.2016.11.016. PubMed PMID: 28017375; PMCID: PMC5223059.

Venkataraman GM, Kennedy LJ, Little ME, Graves SS, Harkey MA, Torok-Storb BJ, Storb R. Thirteen novel canine dog leukocyte antigen-88 alleles identified by sequence-based typing. HLA. 2017;90(3):165-70. Epub 2017 Jul 5. doi: 10.1111/tan.13077. PubMed PMID: 28677267; PMCID: PMC5551428.

2018

Adair JE, Chandrasekaran D, Sghia-Hughes G, Haworth KG, Woolfrey AE, Burroughs LM, Choi GY, Becker PS, Kiem HP. Novel lineage depletion preserves autologous blood stem cells for gene therapy of Fanconi anemia complementation group A. Haematologica. 2018;103(11):1806-14. Epub 2018/07/07. doi: 10.3324/haematol.2018.194571. PubMed PMID: 29976742; PMCID: PMC6278989.

Graves SS, Parker MH, Stone D, Sale GE, Pillai SPS, Johnson MM, Storb R. Anti-inducible costimulator monoclonal antibody treatment of canine chronic graft-versus-host disease. Biol Blood Marrow Transplant. 2018;24(1):50-4. Epub 9/25/2017. doi: 10.1016/j.bbmt.2017.09.010. PubMed PMID: 28958896; PMCID: PMC5743626.

Haworth KG, Schefter LE, Norgaard ZK, Ironside C, Adair JE, Kiem HP. HIV infection results in clonal expansions containing integrations within pathogenesis-related biological pathways. JCI Insight. 2018;3(13):In press (doi: 10.1172/jci.insight.99127). Epub 2018/07/13. doi: 10.1172/jci.insight.99127. PubMed PMID: 29997284; PMCID: PMC6124524.

Hullar MAJ, Lampe JW, Torok-Storb BJ, Harkey MA. The canine gut microbiome is associated with higher risk of gastric dilatation-volvulus and high risk genetic variants of the immune system. PLoS One. 2018;13(6):e0197686. Epub 2018/06/12. doi: 10.1371/journal.pone.0197686. PubMed PMID: 29889838; PMCID: PMC5995382.

Joglekar AV, Liu Z, Weber JK, Ouyang Y, Jeppson JD, Noh WJ, Lamothe-Molina PA, Chen H, Kang SG, Bethune MT, Zhou R, Walker BD, Baltimore D. T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable. Proc Natl Acad Sci U S A. 2018;115(8):1877-82. doi: 10.1073/pnas.1718659115. PubMed PMID: 29437954; PMCID: PMC5828616.

Kotha S, Sun S, Adams A, Hayes B, Phong KT, Nagao R, Reems JA, Gao D, Torok-Storb B, Lopez JA, Zheng Y. Microvasculature-directed thrombopoiesis in a 3D in vitro marrow microenvironment. PLoS One. 2018;13(4):e0195082. Epub 2018/04/05. doi: 10.1371/journal.pone.0195082. PubMed PMID: 29617409; PMCID: PMC5884538.

Kotha SS, Hayes BJ, Phong KT, Redd MA, Bomsztyk K, Ramakrishnan A, Torok-Storb B, Zheng Y. Engineering a multicellular vascular niche to model hematopoietic cell trafficking. Stem Cell Research & Therapy. 2018;9(1):77. doi: 10.1186/s13287-018-0808-2. PubMed PMID: 29566751; PMCID: PMC5865379.

Lee SY, Olsen P, Lee DH, Kenoyer AL, Budde LE, O'Steen S, Green DJ, Heimfeld S, Jensen MC, Riddell SR, Press OW, Till BG. Preclinical pptimization of a CD20-specific chimeric antigen receptor vector and culture conditions. J Immunother. 2018;41(1):19-31. doi: 10.1097/CJI.0000000000000199. PubMed PMID: 29176334; PMCID: PMC5759780.

Li C, Psatha N, Gil S, Wang H, Papayannopoulou T, Lieber A. HDAd5/35(++) adenovirus vector expressing anti-CRISPR peptides decreases CRISPR/Cas9 toxicity in human hematopoietic stem cells. Mol Ther Methods Clin Dev. 2018;9:390-401. doi: 10.1016/j.omtm.2018.04.008. PubMed PMID: 30038942; PMCID: PMC6054697.

Li C, Psatha N, Wang H, Singh M, Samal HB, Zhang W, Ehrhardt A, Izsvak Z, Papayannopoulou T, Lieber A. Integrating HDAd5/35++ vectors as a new platform for HSC gene therapy of hemoglobinopathies. Mol Ther Methods Clin Dev. 2018;9:142-52. doi: 10.1016/j.omtm.2018.02.004. PubMed PMID: 29766024; PMCID: PMC5948227.

Liu N, Hargreaves VV, Zhu Q, Kurland JV, Hong J, Kim W, Sher F, Macias-Trevino C, Rogers JM, Kurita R, Nakamura Y, Yuan GC, Bauer DE, Xu J, Bulyk ML, Orkin SH. Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch. Cell. 2018;173(2):430-42 e17. doi: 10.1016/j.cell.2018.03.016. PubMed PMID: 29606353; PMCID: PMC5889339.

Nambiar M, Smith GR. Pericentromere-specific cohesin complex prevents meiotic pericentric DNA double-strand breaks and lethal crossovers. Mol Cell. 2018;71(4):540-53 e4. doi: 10.1016/j.molcel.2018.06.035. PubMed PMID: 30078721; PMCID: PMC6097939.

Paul B, Ibarra GSR, Hubbard N, Einhaus T, Astrakhan A, Rawlings DJ, Kiem HP, Peterson CW. Efficient enrichment of gene-modified primary T cells via CCR5-targeted integration of mutant dihydrofolate reductase. Molecular Therapy - Methods & Clinical Development. 2018;5(9):347-57. PubMed PMID: 30038938; PMCID: PMC6054698.

Psatha N, Reik A, Phelps S, Zhou Y, Dalas D, Yannaki E, Levasseur DN, Urnov FD, Holmes MC, Papayannopoulou T. Disruption of the BCL11A erythroid enhancer reactivates fetal hemoglobin in erythroid cells of patients with beta-thalassemia major. Mol Ther Methods Clin Dev. 2018;10:313-26. doi: 10.1016/j.omtm.2018.08.003. PubMed PMID: 30182035; PMCID: PMC6120587.

Salter AI, Ivey RG, Kennedy JJ, Voillet V, Rajan A, Alderman EJ, Voytovich UJ, Lin C, Sommermeyer D, Liu L, Whiteaker JR, Gottardo R, Paulovich AG, Riddell SR. Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function. Sci Signal. 2018;11(544). doi: 10.1126/scisignal.aat6753. PubMed PMID: 30131370; PMCID: PMC6186424.

Wang H, Richter M, Psatha N, Li C, Kim J, Liu J, Ehrhardt A, Nilsson SK, Cao B, Palmer D, Ng P, Izsvak Z, Haworth KG, Kiem HP, Papayannopoulou T, Lieber A. A combined in vivo HSC transduction/selection approach results in efficient and stable gene expression in peripheral blood cells in mice. Mol Ther Methods Clin Dev. 2018;8:52-64. Epub 2017/12/20. doi: 10.1016/j.omtm.2017.11.004. PubMed PMID: 29255741; PMCID: PMC5722719.

Zhen A, Peterson CW, Carrillo MA, Reddy SS, Youn CS, Lam BB, Chang NY, Martin HA, Rick JW, Kim J, Neel NC, Rezek VK, Kamata M, Chen ISY, Zack JA, Kiem HP, Kitchen SG. Correction: Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS. PLoS Pathog. 2018;14(3):e1006891. doi: 10.1371/journal.ppat.1006891. PubMed PMID: 29529058; PMCID: PMC5846784.

2019

Bai T, Li J, Sinclair A, Imren S, Merriam F, Sun F, O'Kelly MB, Nourigat C, Jain P, Delrow JJ, Basom RS, Hung HC, Zhang P, Li B, Heimfeld S, Jiang S, Delaney C. Expansion of primitive human hematopoietic stem cells by culture in a zwitterionic hydrogel. Nat Med. 2019. doi: 10.1038/s41591-019-0601-5. PubMed PMID: 31591594.

Hsu J, Reilly A, Hayes BJ, Clough CA, Konnick EQ, Torok-Storb B, Gulsuner S, Wu D, Becker PS, Keel SB, Abkowitz JL, Doulatov S. Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes. Blood. 2019;134(2):186-98. Epub 2019 Apr 22. doi: 10.1182/blood.2018884338. PubMed PMID: 31010849.

Kuhlmann AS, Haworth KG, Barber-Axthelm IM, Ironside C, Giese MA, Peterson CW, Kiem HP. Long-term persistence of anti-HIV broadly neutralizing antibody-secreting hematopoietic cells in humanized mice. Mol Ther. 2019;27(1):164-77. Epub 2018/11/06. doi: 10.1016/j.ymthe.2018.09.017. PubMed PMID: 30391142; PMCID: PMC6318702.

Radtke S, Chan YY, Sippel TR, Kiem HP, Rongvaux A. MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells. Exp Hematol. 2019;70:31-41 e1. Epub 2018/12/28. doi: 10.1016/j.exphem.2018.12.003. PubMed PMID: 30590092; PMCID: In process.

Shahbazi R, Sghia-Hughes G, Reid JL, Kubek S, Haworth KG, Humbert O, Kiem HP, Adair JE. Targeted homology-directed repair in blood stem and progenitor cells with CRISPR nanoformulations. Nature materials. 2019. Epub 2019/05/28. doi: 10.1038/s41563-019-0385-5. PubMed PMID: 31133730; PMCID: NIHMSID1527715.

Sippel TR, Radtke S, Olsen TM, Kiem HP, Rongvaux A. Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models. Blood Adv. 2019;3(3):268-74. Epub 2019/01/31. doi: 10.1182/bloodadvances.2018023887. PubMed PMID: 30696625.

2020

Toran PT, Wohlfahrt M, Foye J, Kiem HP, Wojchowski DM. Assessment and streamlined preparation of low-cytotoxicity lentiviral vectors for mobilized human hematopoietic stem cell transduction. Exp Hematol. 2020 Jun;86:28-42.e3. doi: 10.1016/j.exphem.2020.05.009. Epub 2020 May 27. PMID: 32473295; PMCID: PMC7372909.

Bi L, Wacker BK, Stamatikos A, Sethuraman M, Komandur K, Dichek DA. Jugular Vein Injection of High-Titer Lentiviral Vectors Does Not Transduce the Aorta-Brief Report. Arterioscler Thromb Vasc Biol. 2021 Mar;41(3):1149-1155. doi: 10.1161/ATVBAHA.120.315125. Epub 2020 Dec 10. PMID: 33297756; PMCID: PMC7901533.