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New Scientific Publications
Each week, Fred Hutch librarians search PubMed and Web of Science to discover new papers published by Fred Hutch authors
Week of April 05, 2020
Tip Sheet: Tracking COVID-19, protein design, TB vaccines, a new brain map and more
SEATTLE – April 2, 2020 – Below are summaries of recent Fred Hutch research findings with links for additional background and media contacts.
New research uncovers how common genetic mutation drives cancer
Findings in Nature show that targeted therapy for mutated gene can slow or prevent tumor growth in many kinds of cancer
Retargeting homing endonucleases to cleave new DNA sequences
From the Stoddard Laboratory (Basic Sciences Division)
UPF1 as the ultimate reaper: degrading mRNAs and proteins
From the Bradley Laboratory (Public Health and Basic Sciences Divisions)
Good News: Dr. Jeff Whiteaker wins NCI Research Specialist Award; Human Biology gains four new faculty members
Celebrating faculty and staff achievements
New methods to design small, targeted proteins with shapes not found in nature
Researchers develop methods to design small, targeted proteins with shapes not found in nature
Building a better protein in the hope of better therapies
Researchers design and create donut-shaped proteins from scratch
Evolutionary biologist Bloom wins Sloan Foundation fellowship
Jesse Bloom's $50,000 award supports molecular evolution research of proteins and viruses
Team solves structure of promising gene-targeting protein
Barry Stoddard and colleagues are first to show TAL effector structure, paving way for use in gene modification, engineering and corrective therapy
Biologist Bradley joins Center
Robert Bradley brings expertise in understanding alternative splicing to Basic Sciences and Public Health Sciences divisions
Systems biology may improve early detection of aggressive breast cancer
Chris Kemp and Sam Hanash’s study is the first to examine how blood protein levels change as cancer develops—long before the disease is clinically detectable
Using a 'systems biology' approach to look under the hood of an aggressive form of breast cancer
Study is the first to examine how blood protein levels change as cancer develops – long before the disease is clinically detectable
Jerome, Kiem lead $20 million study to cure HIV
Five-year, federally funded research will test transplantation of gene-modified immune cells
New squamous cell carcinoma drug target discovered
Vasioukhin and colleagues find alpha-catenin protein acts as a tumor suppressor, cell growth control mechanism revealed
Fred Hutchinson Cancer Research Center scientists discover new drug target for squamous cell carcinoma
Researchers find that the protein alpha-catenin acts as a tumor suppressor and they reveal the mechanism by which it controls cell growth
Brain cell migration may offer clues to cancer metatasis
Cooper, Jossin find surprising new role for N-cadherin; finding could shed light on how normal and cancerous cells migrate within the body
$4.8 million grant launches massive proteomics feasibility study
Paulovich’s goal of measuring all human proteins similar to Human Genome Project
Lessons from evolutionary battle scars
Identifying protein locked in conflict with immunity gene could lead to novel ways to tackle diseases caused by alphaviruses