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New Science Spotlight Articles
Every month, Fred Hutch postdoc writer/editors summarize two papers from each of our scientific divisions to stimulate collaborations across campus
September 21, 2020
YAP1 gene fusions are oncogenic drivers in several tumor types and potential therapeutic targets
From the Holland, Paddison, Vasioukhin, and Gujral labs, Human Biology Division
Improved CRISPR-Cas9 delivery method allows for fast and precise knockouts
From the Paddison lab, Human Biology Division
New Scientific Publications
Each week, Fred Hutch librarians search PubMed and Web of Science to discover new papers published by Fred Hutch authors
Week of September 20, 2020
'Everything we’ve been training for is happening now'
How early-career virologists dropped everything to seize the opportunity, and face the challenges, of studying the coronavirus
Stalled science, missed mates and virtual everything
Torn between science and safety concerns, young scientists navigate a new normal as they try to launch their careers
New insights into drug resistance in small cell lung cancer
Scientists discover a single gene’s outsized role in drug resistance — and use its vulnerability to re-sensitize tumors to chemotherapy in preclinical models
Can a tumor that acts like a microbe help us develop better cancer therapies?
Understanding the genetics underlying spontaneous regression of an infectious tumor in Tasmanian devils could point us toward new treatment targets
Shifting liver cancer cells away from migratory state could reduce their drug resistance
Researchers hope lab-based study helps build foundation for personalized treatment of hepatocellular carcinoma
WATCH: Why Dr. Andrew Hsieh is optimistic about the future of treatment for bladder cancer
Physician-scientist aims to make a difference for patients with 'understudied' cancer
A translational regulatory mechanism suppresses epidermal overgrowth
From the Beronja lab, Human Biology Division
New study shows cancer-causing ‘Frankengene’ mutation could be target for new drugs
This gene is fused to many partner genes in different tumors. Now, scientists know it causes cancer — and how they might intervene
A3C tandem domain proteins have increased anti-HIV-1 activity and are resistant to antagonism by HIV-1 Vif
From the Emerman laboratory, Human Biology Division
Mutated skin stem cells self-correct to prevent cancer
New study helps explain why inherited cancer-driving mutations don’t always lead to cancer
Mourning Dr. Supriya 'Shoop' Saha, rising star in liver cancer research
'Truly gifted' physician-scientist made lasting impact in cholangiocarcinoma
In cancer, the context 'makes' the mutation
Whether a mutated gene suppresses or promotes small-cell lung cancer depends on other mutations
Location, location, location: in situ phosphorylation screen reveals novel cell cycle kinase substrate landscape
From the Clurman Laboratory, Human Biology and Clinical Research Divisions
TRIMs attack: TRIM34 and TRIM5alpha work together to block HIV-1 infection
From the Emerman laboratory, Human Biology and Basic Sciences Divisions
Dr. Julie Overbaugh elected to American Academy of Arts & Sciences
Her HIV research revealed factors that influence HIV transmission
Longitudinal RNA expression study identifies candidate biomarkers for FSHD
From the Tapscott laboratory, Human Biology Division
Pushing science forward while working from home
As COVID-19 forces research labs to drastically reduce on-site operations, scientists figure out how to advance their work and stay connected
A short primer on coronavirus biology
Hutch virologist explains viral pandemics and COVID-19