My scientific and medical career has been devoted primarily to discovering and advancing new therapies for children with brain cancer. My lab completed pre-clinical mouse studies that led to 4 national clinical trials, of which I lead a Phase III trial in 250 institutions. Three more trials are in development. We generated the most widely used mouse model of medulloblastoma for translational research studies and established a platform in which we generate personalized mouse models and cancer stem cell lines from individual children that undergo brain cancer surgery so that their therapy can be optimized by pre-clinical studies done on their own cancer. As a pediatric oncologist, I care for children with brain tumors and lead a 17 person brain tumor research laboratory.