Clinical Research Division, Fred Hutch
Dr. Antonio Bedalov studies chromatin, the material that makes up the chromosomes of humans and other eukaryotes. He is learning how chromatin modifications influence important biological events within the cell’s nucleus and, in turn, how they affect development, aging and cancer formation. He also applies this knowledge to lay the groundwork for potential new therapies to treat cancer and other diseases. He has three main research areas. First, he studies how cells regulate the transcription and replication of repetitive DNA sequences. He also studies what happens when these processes break down. Second, Dr. Bedalov is developing potential cancer drugs called sirtuin inhibitors that affect a cell process for regulating gene expression. Dr. Bedalov and collaborator Dr. Julian Simon identified the first sirtuin inhibitors, including one with potent cancer-killing abilities in lab studies. Third, Dr. Bedalov studies X-chromosome inactivation, in which the cells of females silence one of their two X chromosomes. He is interested in manipulating this process as a therapy for Rett syndrome, a genetic disorder that results from a broken gene on one X chromosome.
Associate Professor, Medicine
Adjunct Associate Professor, Biochemistry
University of Washington
1989, M.D. in Medicine, University of Zagreb School of Medicine, Zagreb, Croatia
1993, Ph.D. in Medical Sciences, University of Zagreb School of Medicine, Zagreb, Croatia
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