Basic Sciences Division, Fred Hutch
Dr. Richard Adeyemi studies how our cells maintain the integrity of their DNA. Unstable DNA, leading to rearrangements, extra copies and even loss of genetic information, is a hallmark of cancer. In particular, Adeyemi focuses on how cells protect their genetic information by coordinating and deploying their DNA repair machinery, both during normal replication and in response to events that could damage DNA, including viral infection and chemotherapy. A deeper understanding of the molecular mechanisms underlying these processes will support his work toward novel therapies for cancer, infections, aging and genetic diseases.
Harvard Medical School, 2020, Postdoctoral Fellowship (Genetics)
University of Missouri, 2012, Ph.D. (Microbiology)
University of Ibadan, 2005, D.V.M.
DNA repair and the replication stress response
CRISPR and ORFeome library screens
DNA virus-host interactions
RNA polymerase, lncRNAs and RNA-DNA hybrid roles in DNA repair
BRCA and other tumor suppressor gene roles in cancer
Ubiquitin ligases and the regulation of protein stability