Public Health Sciences Division, Fred Hutch
Basic Sciences Division
Dr. Robert Bradley is a computational biologist and biophysicist who studies alternative splicing, the process by which a single gene can give rise to multiple distinct proteins. This mechanism, which affects most human genes, enormously increases the complexity of our genome and plays important roles in the development of many tumors and genetic diseases. Gaining a better understanding of this process is important, as errors in normal splicing can cause diseases ranging from muscular dystrophies to cancer. Dr. Bradley explores the origins and consequences of alternative splicing and other RNA processes in his laboratory. Topics of interest include the consequences of mutations that affect RNA splicing factors in myelodysplastic syndromes — a class of blood disorders in which the bone marrow is unable to replenish functional blood cells — and the role of nonsense-mediated decay (a sort of cellular fail-safe system) in facioscapulohumeral muscular dystrophy, a disorder characterized by muscle weakness and atrophy. In the long term, he seeks to identify new biological factors that inform the development of new and improved treatments and therapies for MDS, muscular dystrophies and other diseases.
Ph.D. in Biophysics, 2008, University of California, Berkeley
A.B. in Physics with Highest Honors, 2004, Princeton University
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