Spatial Biology Services

Integrated Spatial Multiomics Solutions

We combine advanced technologies such as spatial transcriptomics, multiplexed imaging, and in situ sequencing to map cellular components in their native tissue context. Obtain high-resolution data that reveals intricate spatial patterns and cellular interactions. Our full suite of spatial biology services includes expert consultation, sample preparation, imaging, sequencing, data processing, and delivery. Ideal for research in cancer, neuroscience, immunology, microbiology, infectious diseases, and developmental biology. 

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For project planning, pricing, and grant support, contact our spatial biology team:

Xenium In Situ spatial profiling technology enables high-throughput, subcellular mapping of RNA targets and proteins within a single tissue section. Researchers can streamline workflows from FFPE or frozen tissue samples to data using an automated analyzer, pre-designed or custom gene panels, and integrated data analysis and visualization software. Tissue slides may be suitable for additional applications following a Xenium assay.

Image of hand wearing rubber gloves holding a pipette and slide
Application of reagents to a tissue-mounted Xenium slide as part of the Xenium in situ spatial transcriptomics workflow Photo by Robert Hood/ Fred Hutch Marketing and Communications

This high-plex spatial imaging platform enables mapping of RNA and protein expression at cellular and subcellular resolution. Researchers can now profile the whole transcriptome using this technology. Users have the option to create custom RNA and protein panels along with pre-designed panels, subject to certain restrictions. RNA and protein assays can be performed on serial tissue sections.

Researcher in front of a CosMx machine
A researcher prepares the CosMx Spatial Molecular Imager for data acquisition by loading a CosMx imaging tray Photo by Robert Hood/ Fred Hutch Marketing and Communications

Visium and Visium HD spatial transcriptomics platforms that allow researchers to analyze gene expression across entire transcriptomes within the spatial context of tissues, down to single-cell resolution. We also offer the Visium-CytAssist setup, providing researchers with greater flexibility to target specific regions within large tissue sections on glass slides. These technologies support the detection of RNA or protein (limited) across multiple species, including mouse, human, chicken, fish, and more, subject to certain restrictions.

Image of gloved hands loading tissue slides in the Visium CytAssist machine
Loading tissue slides onto the Visium CytAssist instrument, a key step in the Visium HD spatial transcriptomics workflow. Photo by Robert Hood/ Fred Hutch Marketing and Communications

GeoMx Spatial Technology combines high-resolution imaging with sequencing to analyze RNA and protein expression within tissue sections. Researchers can define regions of interest and use fluorescent markers to segment these regions into distinct tissue compartments or cell populations, allowing for precise gene expression profiling.

Researcher sits in front of a computer in gloves looking at images on a computer monitor
A researcher using the GeoMx Digital Spatial Profiler to select Areas of Illumination (AOIs) on fluorescently stained tissue sections. Photo by Robert Hood/ Fred Hutch Marketing and Communications
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Questions about our histology services or how to schedule with us?