Cellular Imaging

State-of-the-Art Light and Electron Microscopy

The Cellular Imaging shared resource at Fred Hutch provides comprehensive microscopy services for biomedical and translational research including advanced light microscopy and electron microscopy. Our expert staff provides a complete workflow, including training for independent, 24/7 work in the core; assistance and technical support in microscopy techniques and their application; and tailored quantitative image analysis. We work with Fred Hutch users as well as external users from academia and industry.

Fred Hutch and Leica Microsystems have combined efforts to establish a Leica Center of Excellence in the Cellular Imaging core in support of a mission to drive new discoveries and insights from scientific research performed using the imaging systems.

Cellular Imaging - Cord blood CD34 cells generate in vitro erythroid islands. Eyayu Belay from Beverly Torok-Storb lab

Electron Microscopy

We offer consultation, training and specimen preparation for scanning and transmission electron microscopy, or SEM and TEM. Our equipment includes a 6610LV SEM instrument with high- and low-vacuum operation, a 120kV TEM instrument and a range of equipment for specimen processing. 

Image by Eyayu Belay, Torok-Storb Lab, Fred Hutch

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Exp 53 Ms 14 VT Region 001 Uterus Highlight. Veronica Dave from Jennifer Lund lab and Martin Prlic lab

Light Microscopy

We offer a range of state-of-the-art equipment, knowledge and expertise in light microscopy, or LM. Our instruments include systems for incubator microscopy, automated image-based screening, super-resolution confocal microscopy, 3D light-sheet microscopy, and gel and blot imaging.

Image by Veronica Dave, Lund Lab and Prlic Lab, Fred Hutch

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Image Analysis

Image Analysis

Cellular Imaging offers support and training in image analytics with the deployment of multiple workstations equipped with open-source and commercial software dedicated to image processing, quantification and visualization. In addition, we also build personalized image analysis pipelines and algorithms for processing high-content datasets or complex imaging experiments.

Image by Andrea Doak, Cheung Lab, Fred Hutch

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Our Team at Work

Our staff are experts in the use and application of technologies for electron and light microscopy in biomedical research. Our team provides comprehensive project consultation; completely assisted technical support in sample preparation, imaging and analysis; and personalized training to users who wish to become expert, independent microscopists.

14

light microscopes
Our systems include wide-field, confocal and super-resolution microscopy.

50

nm resolution
Our Leica SP8 instrument offers STED super-resolution imaging

0.37

nm point resolution
Our TEM system images cell structures at high resolution and high magnification.

3.0

nm resolution
We offer high-resolution SEM imaging of whole cells, Drosophila and more.

How to Reach Us

Dr. Peng Guo

Director, Cellular Imaging shared resource