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From dream to legacy: Couple accelerates lung cancer research
Vinh Bui and Tram Le establish endowed chair supporting Dr. David MacPherson
Control de la quimiorresistencia con KEAP en el CPCP
Del Laboratorio MacPherson, División de Biología Humana
KEAP-ing chemoresistance at bay in SCLC
From the MacPherson Lab, Human Biology Division
Fred Hutch study finds genetic driver of drug resistance in small cell lung cancer
Researchers use CRISPR-Cas9 gene-editing tool on tumor cells grown in mice to better model how tumors that initially respond to chemotherapy become resistant
Las células cancerosas también valoran a sus redes de apoyo familiar
Del laboratorio Eisenman, División de Ciencias Básicas, y del laboratorio MacPherson, División de Biología Humana.
Family support networks are important for cancer cells, too
From the Eisenman lab, Basic Sciences Division, and the MacPherson lab, Human Biology Division
Targeted new approach and computational tools reveal lung cancer subtypes hiding in patterns in cell-free DNA
Innovative strategy a step toward liquid biopsy to detect, monitor aggressive small cell lung cancer
When antibodies become anti-body
From the Houghton and Lampe labs, Clinical Research and Public Health Sciences Divisions
MacPherson Lab puts immunologically cold cancers in the hot seat with combination therapy
From the MacPherson and Srivastava Labs, Cancer Basic Biology and Cancer Immunology Programs, Cancer Consortium.
Making immunotherapy more effective against small cell lung cancer
Human trial opens after experimental drug improves tumor growth suppression in mice
MYCN drives the development of chemoresistance in small cell lung cancer
From the MacPherson lab, Human Biology Division
Tip Sheet: Colorectal cancer, COVID-19 super-spreading, gene therapy for herpes, contagious cancer in Tasmanian devils – and more
Summaries of recent Fred Hutch research findings and other news with links for additional background and media contacts.
New insights into drug resistance in small cell lung cancer
Scientists discover a single gene’s outsized role in drug resistance — and use its vulnerability to re-sensitize tumors to chemotherapy in preclinical models
MAX is a context-dependent tumor suppressor in small cell lung carcinoma
From the MacPherson and Eisenman labs, Human Biology Division
In cancer, the context 'makes' the mutation
Whether a mutated gene suppresses or promotes small-cell lung cancer depends on other mutations
New program to fast-track lung cancer research from lab to clinic
Patient-focused science at the heart of $13M National Cancer Institute grant
LSD1 inhibition makes a NOTCH in SCLC
From the MacPherson lab, Human Biology Division
Q&A: A new focus on small cell lung cancer
Dr. David MacPherson discusses the state of small cell lung cancer research, how his lab is tackling this deadly disease, and what makes him excited for the future