Cancer Prevention Research

Since its initial inception in 1983, the Cancer Prevention Program has grown into the largest and most diverse program in PHS with expertise in epidemiology, biostatistics, nutrition, genomics, behavioral science, health economics, health disparities, health communications, dissemination and implementation, primary care and oncology. Through interdisciplinary collaborations, CP faculty and staff are dedicated to the mission of preventing chronic disease and its consequences by identifying exposures, understanding mechanisms, and developing effective interventions. Faculty members frequently conduct laboratory-based investigations related to risk, exposure and biomarker assessment that inform interventions. We continue to be at the forefront of nutrition and cancer research.


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Labs & Groups  |  Featured Programs  |  Projects & Studies

Labs & Groups

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Carlson Studies

The Carlson group uses genetic epidemiology to investigate the genetic risk factors of diseases such as cancer, cardiovascular and neurological disease. The molecular biology lab explores the underlying molecular mechanisms behind these correlations.

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Ceballos Studies

The Ceballos group works with community partners at all stages of the research process to develop and evaluate culturally appropriate interventions to reduce social and emotional burdens of cancer in underserved communities. 

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Grady Lab

The Grady Lab is focused on the role of genomic and epigenomic alterations in gastrointestinal carcinogenesis, specifically esophageal adenocarcinoma (EAC) and colorectal cancer (CRC). 

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Greenlee Studies

The Greenlee group focuses on behavioral interventions for cancer prevention and control as well as validating and testing complementary and integrative approaches to cancer survivorship. In essence, we want to understand what cancer survivors can do, in addition to conventional care, to improve cancer outcomes.

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Health Communication Research Center

Health Communication Research Center (HCRC) develops, tests, evaluates and disseminates theory-based health communication interventions using various media including prints, podcasts, internet websites, and social media.

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Health and Behavioral Innovations in Technology

Health and Behavioral Innovations in Technology (HABIT) designs, develops, tests, and disseminate techology-delivered interventions for health behavior change. Our goals are to develop and test technologies to help one million people quit smoking, eat healthy and lose weight.

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Jones Lab

The Jones Lab research focuses on understanding financial hardship and financial anxiety affect health, quality of life and disease outcomes and testing unique methods of interpreting patient-reported outcomes to measure effectiveness of clinical care and adapt methods for use in oncology clinical trials.

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Kensler Lab

The Kensler Lab studies adaptive responses to endogenous and exogenous stress as targets for cancer prevention with a primary focus on the KEAP1-NRF2 signaling pathway. Research includes the discovery and translation of small molecule activators of the pathway and the conduct of clinical trials of NRF2 inducers in populations unavoidably exposed to high levels of environmental carcinogens.

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Neuhouser Lab

The Neuhouser Lab's research focuses on investigating the role of modifiable lifestyle factors, including nutrition, physical activity and energy balance/obesity and their relationship to the etiology and prevention of cancer. Research investigates methodologies to improve upon dietary self-report, novel methods to characterize food intake, innovative intervention strategies and applications to large cohorts with well-characterized and adjudicated clinical outcomes.

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Peters Lab

The peters Lab is studying the impact of genetic variants across the genome, as well as interactions of genetic variants with lifestyle and environmental risk factors. We are also conducting large-scale studies to analyze molecular and genetic characteristics of colorectal tumors and their microenvironment in relation to host genomes, lifestyle and environmental risk factors, and survival. 

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Tobacco-Related Health Disparities Research Group

The Tobacco-Related Health Disparities (TREHD) Research Group focuses on research to improve treatment for tobacco-related health disparities groups — including people with mental health conditions and Veterans receiving care through the Veterans Health Administration (VHA) — by testing new treatment content and increasing treatment accessibility through high-reach delivery modalities of telephone, web and mobile.

Featured Programs

Drs. Flowers adn Ramsey speaking at a Value in Cancer Care Summit

Hutchinson Institute for Cancer Outcomes Research

Wendy Barrington, right, works with Cindy Pulido during the OCOE's Community Grant Writing Workshop

Office of Community Outreach & Engagement

Dr. Unger presenting at a SWOG conference

Southwest Oncology Group

A woman with her granddaughter

Women's Health Initiative

Hutchinson Institute for Cancer Outcomes Research

Hutchinson Institute for Cancer Outcomes Research (HICOR) is a research institute at Fred Hutch whose mission is to improve cancer prevention, detection and treatment in ways that will reduce the economic and human burden of cancer — and ultimately lead to better outcomes for patients. To achieve this, HICOR brings together researchers, patient partners, clinicians, payers and policymakers to share cancer-related data and generate clinically relevant performance metrics that can guide improvements in cancer care.

Projects & Studies

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Advanced Colorectal Cancer of Serrated Subtype (ACCESS) Study

Public Health Sciences, Cancer Prevention

Researchers are studying a subtype of colorectal cancer (CRC) that develops via the serrated pathway with a goal of determining future prevention strategies and advancing treatment for CRC.

Funding Agency: National Institutes of Health

Contact: Rachel Malen, rmalen@fredhutch.org

Ancillary Cost-Effectiveness Analysis

Public Health Sciences, Cancer Prevention

Researchers are determining the cost-effectiveness of cord blood vs. haplo matched relatives using clinical information from the Bone Marrow Transplant (BMT) Clinical Trials Network (CTN) and insurance claims data.

Funding Agency: National Institutes of Health

Contact: Jordan Steelquist, jsteelq@fredhutch.org

Cancel Save & Close Menopause Strategies: Finding Lasting Answers for Symptoms and Health (MsFLASH)

Public Health Sciences, Cancer Prevention

The MsFLASH network conducts clinical trials aimed at finding promising treatments for the most common symptoms of menopause.

Carotene and Retinol Efficacy Trial (CARET)

Public Health Sciences, Cancer Prevention

Researchers tested the efficacy and safety of beta-carotene and retinyl palmitate in people at high risk for lung cancer in a randomized, double-blind, placebo-controlled trial. Active follow-up of trial. participants ended on June of 2005; however, the program continues to support the extensive biological repository and ancillary studies that use CARET samples and data.

Funding Agency: National Cancer Institute

Contact: Jackie Dahlgren, jdahlgre@fredhutch.org

Clinical and Economic Value of Next Generation Sequencing-Based Diagnostic Testing in Cancer Care

Public Health Sciences, Cancer Prevention

Researchers are developing a decision model designed to evaluate the cost effectiveness of multiplex NGS testing vs. usual care. They plan to pair the decision model with information theory to identify the most efficient and impactful study designs.

Funding Agency: Personalized Medicine Coalition

Contact: Jordan Steelquist, jsteelq@fredhutch.org

Collaboration for a Healthy Community (Together We STRIDE)

Public Health Sciences, Cancer Prevention

The goal of the project is to build and enhance community capacity and infrastructure on childhood obesity initiatives in the Lower Yakima Valley, Washington.

Funding Agency: National Institute on Minority Health and Health Disparities

Contact: Sonia Bishop, sbishop@fredhutch.org

Colorectal Research in Epidemiology (CORE) Family Studies

Public Health Sciences, Cancer Prevention

Working with biological specimens, medical records and interviews, researchers investigate how genetic, environmental and lifestyle factors effects the incidence of colon and rectal cancers.

Funding Agency: National Institutes of Health

Contact: Rachel Malen, rmalen@fredhuthc.org

Cook for Your Life!: Maintaining Diet and Physical Activity

Public Health Sciences, Cancer Prevention

To test the effects of in-person and e-communication (e.g., text, email) interventions on improving diet and physical activity among Latina breast cancer survivors.

Funding Agency: National Institutes of Health / National Cancer Institute

Contact: Lisa Levy, llevy@fredhutch