Researchers performing cryo-EM experiments can acquire the training to make their own cryo-EM and negative-stain grids, and collect and process their own high-resolution data. We also offer sample preparation, data collection and data processing services. Users have access to two transmission electron microscopes. Core staff members are available to consult during project development.
To request services or training, please refer to our rates and scheduling page.
To schedule cryo-EM services with the Electron Microscopy shared resource, or to get more information about how we can work with you, contact our EMSR team:
Theo Humphreys
Associate Director, Electron Microscopy
We are equipped with standard sample-preparation instruments used in negative stain and cryogenic electron microscopy grid generation. Our team provides sample preparation services as well as training in these techniques. We consult with users looking to optimize freezing conditions and overcome challenges, such as preferred orientation and low particle density.
Our core aims to empower users to collect and process their own cryo-EM data. We train users to operate two different transmission electron microscopes, the Talos L120C and the Glacios. Users will learn how to screen grids and collect high-resolution cryogenic data, as well as how to process their data using facility computational resources.
The core provides access to single-tilt grid holders for room-temperature and cryogenic applications using the Talos microscope.
Temporary data storage is available for one month after data collection. On-the-fly motion correction and pre-processing are provided with Glacios reservations. We encourage users to consult with core staff during all stages of project development.