Active Studies

ON THIS PAGE

Disease  |  Types of Studies

Disease

Title: Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL)/CIDR genotyping project
Investigator: Amos, Chris
Institution: Baylor College of Medicine
Objective: To a) genotype an additional 23,103 lung cancer cases and 23,103 unrelated controls within the ILCCO consortium not previously studied by GWAS; b) undertake joint analysis of ~54,000 cases/76,000 controls by combining the new data with existing lung cancer GWAS data; c) conduct analyses such as genome wide association by proxy (GWAx) using individuals from GWAS profiled biobanking data (UKbiobank, PLCO, Million vets); d) identify novel genetic variants and validate top SNPs; and e) refine lung cancer risk prediction algorithms.

Title: Immunogenetic analysis of lung cancer and melanoma to identify the role of iKIRS in malignancy
Investigator: Asquith, Becca
Institution: Imperial College of London
Objective: To elucidate the relevance of the iKIR-HLA receptor ligand system in cancer and analyze the mechanisms by which iKIRs influence T cells. For this purpose we want to determine whether gene variation in HLA and KIR loci is associated with disease outcome in autoimmune diseases and in cancer. 

Title: Germline variation, proteomic regulation and cancer risk and development
Investigator: Getz, Gad
Institution: The Broad Institute
Objective: To investigate the impact of germline variation on proteomic regulation and the roles they play in cancer risk and development. This project aims to: 1) characterize the impact of germline variants on molecular phenotypes (transcriptomic and proteomic); 2) investigate the mechanisms underlying the associations in Aim 1; 3) evaluate the overlap between the associations in Aim 1 and cancer GWAS loci. 

Title: Evaluating associations between lung cancer risk variants and second primary lung cancer (SPLC)
Investigator: Han, Summer
Institution: Stanford University
Objective: To evaluate the genetic, environmental, and clinical determinants of developing second-primary lung cancer (SPLC) among survivors of initial lung cancers using population-based data methods; cohort data from ILCCO and TRICL will be used to identify genetic, clinical, and environmental risk factors for SPLC, which include SNPs, smoking, radiation therapy, COPD, gender, education, race, BMI, and initial primary lung cancer characteristics.

Title: Detailed assessment of smoking, lung cancer incidence and all-cause mortality on four continents
Investigator: Johansson, Mattias
Institution: International Agency for Research on Cancer (IARC)
Objective: To use individual level data from the LC3 to thoroughly assess the relationship between smoking initiation, cessation, duration, and intensity with the risk of incident lung cancer incidence and overall mortality in four continents; and to estimate the contribution of smoking for premature death in different continents.

Title: Clinico-epidemiological prognostic factors for small cell lung cancer
Investigator: Liu, Geoffrey
Institution: Princess Margaret Cancer Center (Toronto)
Objective: To develop separate clinico-epidemiological prognostic Cox models by stage (ED-SCLC; LD-SCLC), evaluating factors such as age, sex, education, smoking, family history, ethnicity, BMI, and comorbidity to determine the magnitude of effect of each putative risk factor on the mortality (or overall survival) of small cell lung cancer. Exploratory analyses will also evaluate lung cancer-specific mortality.

Title: Differential clinico-epidemiological risk and prognostic factors for non-small cell lung cancer by stage
Investigator: Liu, Geoffrey
Institution: Princess Margaret Cancer Center (Toronto)
Objective: To determine whether the magnitude of effect of clinic-epidemiological risk and prognostic factors such as age, sex, education, smoking, BMI, histology, and comorbidity on the development and mortality (or overall survival) of NSCLC differ by stage of disease.

Title: The changing demographics and outcomes in older patients with lung cancer over time
Investigator: Liu, Geoffrey
Institution: Princess Margaret Cancer Center (Toronto)
Objective: To compare 1) the longitudinal changes in clinical demographics at the year of diagnosis of patients with lung cancer of older patients (≥65) compared to younger patients (< 65) and 2) the change in stage- and lung cancer-specific survival based on age group over time. 

Title: Impacts of long term smoking cessation and risk of lung cancer
Investigator: McKay, James
Institution: International Agency for Research on Cancer (IARC)
Objective: This project aims to use the remarkable resources assembled by the International Lung Cancer Consortium (ILCCO) to undertake a detailed description of the epidemiology, genetics and genomic changes related to LC in LTQ and compare and contrast these within more recent quitters and those that continue the smoking habit.

Title: The Lung EArly Proteins project: A LEAP towards implementing biomarkers in lung cancer screening
Investigator: Robbins, Hilary
Institution: International Agency for Research on Cancer (IARC)
Objective: The objective of the LEAP project is to translate a novel panel of protein biomarkers to optimize the decision (1) to initiate screening and (2) to biopsy a nodule. Aim 1 will determine whether repeated measurements of protein markers over time can better predict development of lung cancer than a single measurement. Aim 2 will determine whether the protein markers can identify cancers among high-risk screen-detected lung nodules.

Title: Evaluating risk prediction models for use in lung cancer screening across diverse populations around the world
Investigator: Robbins, Hilary
Institution: International Agency for Research on Cancer (IARC)
Objective: To determine whether established lung cancer risk models can be validly applied in diverse populations worldwide, and to develop new tools for emerging settings in lung CT screening.

Title: Validation and updating lung cancer risk models
Investigator: Teare, M. Dawn
Institution: University of Sheffield School of Health and Related Research
Objective: 1) To identify and review all existing lung cancer risk models (LCRMS). Pay attention to the features of the target population the model was developed for; 2) To evaluate the performance of LCRMs when applied to populations similar and distinct to those developed for. This will produce aggregate data to take to the next stage.(Using ILCCO participating studies); 3) To systematically review and apply the multivariate analyses to combine the evidence for each component predictor and evaluate the performance. Following a framework such as outlined by Gasparini which can handle non linear associations; 4) To formulate a robust and flexible means to assess lung cancer risk.

Title: Environmental factors, gene-environment interactions and bladder cancer risk.
Investigator: Milne, Roger
Institution: Cancer Council Victoria
Objective: To assess associations with bladder cancer risk for predominantly modifiable lifestyle factors for which findings to date have been inconclusive. Pooled prospective data will be used from cohorts participating in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP). Factors to be examined include body size; physical activity; use of aspirin and NSAIDS; reproductive and hormonal risk factors; alcohol, coffee, tea and other beverage consumption; and dietary factors. Assessments will include associations by sex, smoking status and disease subtype, as well as GxE interactions using GWAS data.

Title: Association between adherence to the planetary health diet (PHD) and breast cancer risk in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP)
Investigator: Castellanos Gutiérrez, Analí
Institution: Harvard University
Objective: To investigate associations between adherence to the planetary health diet and risk of breast cancer overall and by molecular subtype and menopausal status in the DCPP

Title: Family history and cancer risk and mortality
Investigator: Genkinger, Jeanine
Institution: Columbia University
Objective: To improve risk assessment and ID factors that could lead to reduced risk and increased screening efficacy of site-specific cancers across the spectrum of familial risk and for people with strong family histories of cancer diseases.

Title: Breast Cancer Risk Prediction Project (BCRPP)
Investigator: Kraft, Peter
Institution: Harvard University
Objective: To assimilate and analyze data on >1.5 million US women from the NCI Cohort Consortium Study to develop a comprehensive tool that will predict breast cancer risk, overall and by sub-types, across major ethnic groups in the US.

Title: Validating existing breast cancer risk prediction models for the general population using self-reported or clinical data across diverse prospective cohorts
Investigator: Kraft, Peter
Institution: Harvard University
Objective: To derive estimated five- and ten-year absolute risks in participating BCRPP cohorts based on the existing risk models, and to estimate calibration and risk discrimination within each cohort included in the BCRPP, stratified by race and ethnicity.

Title: Development and validation of a comprehensive and multi-ancestry breast cancer risk prediction model for the US population using data from the NCI cohort consortium
Investigator: Norton, Emily
Institution: Johns Hopkins University
Objective: To develop and validate a comprehensive risk model framework for diverse populations that allows for inclusion of subsets of factors depending on the application and availability of data, rather than multiple separate models with different risk factor subsets or target populations.

Title: Plant-based diet indices (PDI) and breast cancer risk in the Diet and Cancer Pooling Project.
Investigator: Riseberg, Emily
Institution: Harvard University
Objective: To investigate associations between plant-based diet indices and risk of breast cancer overall and for subtypes defined by hormone receptor status in the Pooling Project of Prospective Studies of Diet and Cancer

Title: Fruits, vegetables, and risk of breast cancer in the Diet and Cancer Pooling Project.
Investigator: Riseberg, Emily
Institution: Harvard University
Objective: To investigate associations between fruit and vegetables and risk of breast cancer overall and for tumor subtypes in the Pooling Project of Prospective Studies of Diet and Cancer

Title: Prediagnostic Vit D & mortality in breast cancer: a pooled analysis
Investigator: Visvanathan, Kala
Institution: Johns Hopkins
Objective: To determine whether pre-diagnostic circulating vitamin D levels are associated with improved survival in patients with breast cancer in the context of the Vitamin D Pooling Project of Breast and Colorectal Cancer, a large consortium of 20 prospective cohort studies from the United States, Europe, and Japan.

Title: Pooled analysis of 25-hydroxy vitamin D and colorectal cancer survival (Harvard Pooling Project)
Investigator: Fedirko, Veronica
Institution: Emory University School of Public Health
Objective: To investigate association between pre-diagnostic 25(OH)D levels and CRC-specific and overall mortality among CRC cases in the VDPP project.

Title: Improving precision prevention of colorectal cancer by accounting for familial risk
Investigator: Genkinger, Jeanine
Institution: Columbia University
Objective: To examine whether associations between dietary intake, physical activity, anthropometry and colorectal cancer risk are modified by underlying familial risk profile.

Title: Risk factors for esophageal cancer: a pooled analysis of prospective studies from the NCI Cohort Consortium
Investigator: Jayasekara, Harindra
Institution: Cancer Council Victoria
Objective: To conduct a pooled analysis using data from participating cohort studies, to estimate associations between smoking; alcohol use; intake of meat and fish; intake of fruit, vegetable and cereal; dietary fiber intake; consumption of sugar-sweetened beverages, coffee and tea; use of aspirin and NSAIDs (and statins where available); and adult height, overweight and obesity, and risk of esophageal adenocarcinoma and esophageal squamous cell carcinoma; and to investigate whether the estimates of association between other factors and risk of esophageal cancer subtypes are modified by smoking status/intensity and body fatness.

Title: Metabolomics, bacterial translocation, and risk of liver cancer: a proposed study within the LCPP and other US based cohorts
Investigator: McGlynn, Katherine
Institution: National Institutes of Health/National Cancer Institute
Objective: To determine the association between metabolites and liver cancer incidence.

Title: Biomarker for early detection of pancreatic cancer
Investigator: Chen, Ru
Institution: Baylor College of Medicine
Objective: To evaluate proteomics biomarkers in detecting pancreatic cancer at asymptomatic or pre-cancer stages.

Title: The population attributable fractions of pancreatic cancer by key risk factors 
Investigator: Stolzenberg-Solomon
Institution: National Cancer Institute
Objective: To determine the population attributable fraction (PAFs) of known risk factors for pancreatic cancer overall and by histologic subtype in the United States, and to assess for select subtypes risk estimates for the associations between smoking, overweight/obesity, alcohol use, and diabetes. 

Title: Coffee intake and advanced prostate cancer: studying risk and mechanisms
Investigator: Wilson, Kathy
Institution: Harvard University
Objective: To investigate the relation between coffee intake and the risk of advanced and fatal prostate cancer in the Pooling Project of Prospective Studies of Diet and Cancer.

Title: Association between adherence to the planetary health diet (PHD) and all-cause, cardiovascular disease, and cancer mortality in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP)
Investigator: Castellanos Gutiérrez, Analí
Institution: Harvard University
Objective: To investigate associations between adherence to the planetary health diet and risk of mortality including all-cause, cardiovascular disease, and cancer mortality overall and by sex and smoking status in the DCPP.

Title: Diabetes and Cancer Initiative in the Cohort Consortium
Investigator: Gunter, Marc
Institution: Imperial College of London
Objective: To further understand the relation of diabetes with cancer both in terms of epidemiology and underlying molecular mechanisms.

Title: A pooling project on alcohol use and risk of cancers with inconsistent prior evidence, with an emphasis in non-smokers
Investigator: Ferrari, Pietro
Institution: IARC and Harvard University
Objective: To estimate the burden of alcohol consumption on site-specific cancer incidence and total and cause-specific mortality using data from the NCI Cohort consortium; dose-response relationships will be investigated using baseline and lifetime alcohol uses.

Title: Population Attributable Fraction (PAF) project
Investigator: MacInnis, Robert
Institution: Cancer Council Victoria
Objective: To estimate PAFs and their CIs for cancer incidence, allowing analysis of the simultaneous effects of multiple factors and accounting for competing risk of death, to the Pooling Project of Prospective Studies of Diet and Cancer (DCPP) in the National Cancer Institute Cohort Consortium and representative external exposure prevalence data.

Types of Studies

Title: Association between adherence to the planetary health diet (PHD) and breast cancer risk in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP)
Investigator: Castellanos Gutiérrez, Analí
Institution: Harvard University
Objective: To investigate associations between adherence to the planetary health diet and risk of breast cancer overall and by molecular subtype and menopausal status in the DCPP.

Title: Association between adherence to the planetary health diet (PHD) and all-cause, cardiovascular disease, and cancer mortality in the Pooling Project of Prospective Studies of Diet and Cancer (DCPP)
Investigator: Castellanos Gutiérrez, Analí
Institution: Harvard University
Objective: To investigate associations between adherence to the planetary health diet and risk of mortality including all-cause, cardiovascular disease, and cancer mortality overall and by sex and smoking status in the DCPP.

Title: Pooled Analysis of 25-hydroxy Vitamin D and Colorectal Cancer Survival (Harvard Pooling project)
Investigator: Fedirko, Veronica
Institution: Emory University School of Public Health
Objective: To investigate association between pre-diagnostic 25(OH)D levels and CRC-specific and overall mortality among CRC cases in the VDPP project.

Title: A Pooling Project on Alcohol Use and Risk of Cancers with Inconsistent Prior Evidence, with an Emphasis in Non-Smokers
Investigator: Ferrari, Pietro
Institution: IARC and Harvard University
Objective: To estimate the burden of alcohol consumption on site-specific cancer incidence and total and cause-specific mortality using data from the NCI Cohort consortium; dose-response relationships will be investigated using baseline and lifetime alcohol uses.

Title: Plant-based diet indices (PDI) and breast cancer risk in the Diet and Cancer Pooling Project.
Investigator: Riseberg, Emily
Institution: Harvard University
Objective: To investigate associations between plant-based diet indices and risk of breast cancer overall and for subtypes defined by hormone receptor status in the Pooling Project of Prospective Studies of Diet and Cancer

Title: Fruits, vegetables, and risk of breast cancer in the Diet and Cancer Pooling Project.
Investigator: Riseberg, Emily
Institution: Harvard University
Objective: To investigate associations between fruit and vegetables and risk of breast cancer overall and for tumor subtypes in the Pooling Project of Prospective Studies of Diet and Cancer

Title: Prediagnostic Vit D & mortality in breast cancer: a pooled analysis
Investigator: Visvanathan, Kala
Institution: Johns Hopkins
Objective: To determine whether pre-diagnostic circulating vitamin D levels are associated with improved survival in patients with breast cancer in the context of the Vitamin D Pooling Project of Breast and Colorectal Cancer, a large consortium of 20 prospective cohort studies from the United States, Europe, and Japan.

Title: Coffee intake and advanced prostate cancer: studying risk and mechanisms
Investigator: Wilson, Kathy
Institution: Harvard University
Objective: To investigate the relation between coffee intake and the risk of advanced and fatal prostate cancer in the Pooling Project of Prospective Studies of Diet and Cancer.