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Shepherd
Annemarie F. Shepherd, MD

Annemarie F. Shepherd, MD

Radiation Oncology

  • Medical Director, Fred Hutch Cancer Center - Proton Therapy
  • Associate Professor, Radiation Oncology Division, Fred Hutch
  • Associate Professor, Division of Radiation Oncology, University of Washington School of Medicine

About

Dr. Annemarie F. Shepherd is a board-certified radiation oncologist and researcher who treats lung cancer, mesothelioma and thymic tumors at Fred Hutch.


Background

Dr. Shepherd is the medical director of Fred Hutch Cancer Center – Proton Therapy. She provides radiation therapy and emphasizes thorough, detail oriented care, encouraging patients to share concerns as they make treatment decisions. She works to ensure radiation treatments are delivered precisely as planned.

Research has been an integral part of Dr. Shepherd’s career. Her work focuses on advancing radiation therapy for thoracic tumors, particularly proton therapy — a type of radiation that uses protons to target tumors more precisely and reduce damage to surrounding tissue. She studies radiation related toxicity, meaning side effects caused by radiation, and why some patients are more sensitive to radiation than others. She has written, run and led multiple clinical trials and published extensively in this area.

Dr. Shepherd has particular interest in thymic tumors, serving on the board of the International Thymic Malignancy Interest Group (ITMIG) and as chair and moderator of the ITMIG Tumor Boards. She has been involved in multiple clinical thymic projects and was the principal investigator of an investigator-initiated trial looking at treating the whole pleura with intensity-modulated pleural radiation therapy using proton therapy in thymic patients with pleural metastases. Her research includes studies of proton therapy for patients who need repeat radiation, have large treatment areas, are at higher risk for radiation complications or require radiation after surgery. 

Area of Clinical Practice
Lung cancer, mesothelioma, thymic tumors


“Each patient comes into treatment with different perspectives and backgrounds. I aim to always make sure I understand every person’s goals and priorities.”

— Dr. Shepherd


How have you been personally impacted by cancer?

Cancer has affected close friends, family members and mentors. I have seen how quickly a diagnosis can turn someone’s world upside down, and I have provided comfort and knowledge to assist loved ones through their own uncertain times. 

I treated a patient who was my age and in a similar phase of life when she was diagnosed with a very aggressive cancer. She tolerated treatment well, completely recovered and continues to be cancer-free. I love seeing her in follow-up care to view how her life continues to parallel mine, despite the major mountain that she had to overcome. She has given me so much perspective about life and family.

How do you approach providing patient care?

Besides my expertise in the field, I think my greatest asset for patients is my ability to share knowledge so they feel empowered. When patients have a better understanding of their situation, they can more confidently make decisions that are in line with their beliefs and desires. I strive to bring peace and understanding to patients through treatment and beyond. 

Diseases Treated

Lung Cancer

Mesothelioma

Thymic Tumors

Dr. Shepherd's research focuses on advancing radiation therapy techniques for patients with thoracic tumors. In lung cancer patients Dr. Shepherd is working to understand the role of post-operative radiation therapy in lung cancer patients as this treatment reduces recurrences in the lymph nodes but may have some side effects. Working to reduce the side effects of radiation therapy, with technologies such as proton therapy, may help to improve outcomes in our lung cancer patients. Dr. Shepherd is also exploring a radiation regimen called quad-shot, which is commonly used in head and neck patients, to understand the benefits of this approach in our lung cancer patients.

Languages

English

Education and Experience

Residency, Radiation Oncology, University of Pennsylvania

MD, Rutgers Robert Wood Johnson Medical School

BS, University of Pennsylvania

Board Certifications

Radiation Oncology, 2016, American Board of Radiology

Awards

ASTRO Annual Meeting Scientific Abstract/Travel Award, 2013

Clinical Trials

We make promising new treatments available to you through studies called clinical trials led by Fred Hutch physicians and researchers. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your physician can decide if a study is right for you.

View Clinical Trials

Publications

Many of our Fred Hutch physicians and researchers conduct ongoing research to improve standards of patient care. Their work is evaluated by other physicians and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch physician has written.

View Dr. Shepherd's Publications

Your Care Team

At Fred Hutch, you receive care from a team of providers with extensive experience in your disease. Your team includes physicians, a patient care coordinator, a registered nurse, an advanced practice provider and others, based on your needs. You also have access to experts like registered dietitians, social workers, acupuncturists, psychiatrists and more who specialize in supporting people with cancer or blood disorders.

Insurance

Fred Hutch accepts most national private health insurance plans as well as Medicare. We also accept Medicaid for people from Washington, Alaska, Montana and Idaho. We are working to ensure that everyone, no matter what their financial situation, has access to the care they need.

Stories

All news
The Beam: Takeaways from NAPT conference, redesigned playroom opens, meet proton registered dietitian Fred Hutch staff share learnings from the proton therapy conference, program coordinator reimagines playroom with business school team, meet Laura Martinell June 2, 2025
The Beam: Consult process for proton therapy, secret lives of staff and meet the newest radiation therapist What is the intake process for proton therapy treatment? Learn about our staff's interests outside of work; meet Paul Lee, RTT March 3, 2025
The Beam: Dr. Annemarie Shepherd on proton therapy for thymic cancers; NAPT celebrates successes and meet Dr. Winston Vuong Why proton therapy is a good option for thymomas, national proton therapy news and the newest genitourinary specialist at the proton therapy facility December 30, 2024