Lung cancer research at Fred Hutch Cancer Center has led to new treatments with significantly higher survival rates than in years past.

Our work spans fundamental studies of the gene changes that drive lung cancer to large-scale population studies that seek to understand why it develops in some people but not others. We also study how noncancerous cells surrounding the tumor may influence its progression.

Lung Cancer Clinical Trials 

Fred Hutch typically has over 750 active cancer clinical trials enrolling participants. 

Clinical trials may allow some patients access to a promising new treatment, and help physicians and researchers learn more about a disease. 

Our Lung Cancer Research Focus

Research to Understand Lung Cancer Risk

Though smoking is perhaps the most well-known risk factor for lung cancer, not everyone who smokes will develop lung cancer. People who have never smoked make up a growing percentage of those diagnosed with lung cancer. Our scientists study the differences in lung tumors in these two populations to seek unique drug targets in each type of tumor. We also perform large-scale population-based studies to better understand why smoking only puts certain people at higher risk for lung cancer. Studies like these could improve our understanding of who is most at risk for lung cancer and help physicians improve screening strategies.

Finding New Ways to Harness the Immune System

Cancer cells are surrounded by noncancerous cells. Many of these can influence tumor cells’ growth, invasiveness and ability to metastasize (spread), or leave the original tumor and initiate new tumors elsewhere. Our investigators study these nontumor cells and how they interact with lung tumor cells. In particular, our scientists focus on cells from the immune system. Insights from these studies could point to new therapeutic targets or ways to harness the immune system itself to target lung cancer. Our scientists also conduct immunotherapy clinical trials for lung cancer.

Discovering New Drug Targets

Understanding the inner workings of cancer cells can help researchers discover new drug targets. Our scientists work to pinpoint the critical genetic changes that promote lung cancer and translate these insights into targeted therapies for patients’ individual tumors.

Fast-Tracking Breakthroughs

The Fred Hutch Lung Specialized Project of Research Excellence (SPORE) works to fast-track the latest breakthroughs in labs to patients and those at risk of developing lung cancer. These researchers are focused on:

  • Facilitation of pulmonary nodule evaluation for lung cancer early detection and screening
  • Lack of effective therapies for small cell lung cancer (SCLC)
  • Sub-optimal response rates of non-small cell lung cancer (NSCLC) patients to novel immune-based therapies

Learn more about Lung SPORE.

Dr. McGarry Houghton
Dr. McGarry Houghton is a lung cancer specialist at Fred Hutch.

Driven to Find Out Why

McGarry Houghton, MD, is a Fred Hutch pulmonologist who oversees lung cancer research at Fred Hutch. Lung cancer rarely develops in normal lungs, he points out. People with lung diseases like chronic obstructive pulmonary disease (COPD) or emphysema are up to five times more likely to develop and die from lung cancer than people who don’t have these conditions.

“The big link in my mind is to figure out why people with chronic lung diseases are set up to get these infections and how that inflammation fuels lung cancer,” said Dr. Houghton. “This idea of studying the previous life of the lung before the lung cancer developed is something very few people do.”

Our Lung Cancer Researchers and Faculty

Our scientists and providers work together to prevent, diagnose and treat lung cancer as well as other cancers and diseases. The lab research and clinical research they do are essential parts of the scientific process that leads to new treatments and better care. Many of our lung cancer providers also do research in addition to seeing patients. Clinical trials can be a way for patients to get early access to new leading-edge therapies, too. Our research teams are running many clinical studies for people with lung cancer.

Lung Cancer News

All news
Lung cancer researchers, advocates gather in Seattle SPORE scientists talk T cells, new targeted therapies, the tumor microenvironment and more at annual meeting June 17, 2026
Fred Hutch cancer care – and reputation – extend to Kitsap Peninsula and beyond Discover how Fred Hutch's Peninsula Clinic offered a patient excellent care closer to home June 10, 2026
Seattle architect was shocked when diagnosed with a rare lung cancer at 31 A second opinion and proton therapy were key to eradicating a neuroendocrine tumor June 1, 2026
Fred Hutch study dramatically expands therapeutic range of approved kinase drugs Large-scale analysis reveals new uses for existing therapies across cancer types and non-cancer diseases April 24, 2026