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Brain trust: HCMV hijacks host chromatin to induce dormant neuronal genes
From the Avgousti Lab, Human Biology Division
X-scape artistry: CTCF insulates X-linked genes from silencing
From the Disteche Lab, University of Washington Department of Laboratory Medicine & Pathology and the Cancer Consortium program in Cancer Basic Biology
Sleepy cells rely on Sir2 to remodel their DNA landscape
From the Tsukiyama Lab, Basic Sciences Division
Switching sides: How MLL-rearranged leukemias leverage oncoproteins to evade treatment
From the Henikoff Lab, Basic Sciences Division
Dr. Toshio Tsukiyama elected to American Academy of Microbiology
Longtime Basic scientist revealed dynamic nature of DNA packaging and how cells exploit it to enter and exit dormancy
New technique could help make precision medicine more widely available
Simple CUT&Tag adaptation gives information about genetic regulatory elements in formalin-fixed tumor samples
An old drug gets a new look: DNA damaging agent aclarubicin found to disrupt chromatin and stimulate RNA Pol II elongation
From the Henikoff Lab, Basic Sciences Division and Cancer Basic Biology Program of the Cancer Consortium
Struggle between sex chromosomes underlies evolutionary paradox
DNA-packaging protamine genes evolve rapidly to stay ahead in battle between ‘selfish’ genetic elements and the rest of the genome
Chromatin researcher and professor of radiation oncology Dr. Mark Groudine retires after four decades
Revealed important nature of DNA packaging, dedicated decades to center administration
Unlocking more information from liquid biopsies
Dr. Gavin Ha receives $1.5M NIH Director’s New Innovator Award for creative young scientists with high-risk, high-reward projects
What viruses can teach us about ourselves
Dr. Daphne Avgousti studies viruses that can give us a window into fundamental human biology that we can use to improve our health
Chromatin fibers: oh what a tangled web we weave
From the Tsukiyama Lab, Basic Sciences Division
Rude Awakening: examining the cell’s rapid recovery from quiescence
From the Tsukiyama lab, Basic Sciences Division
New method quickly, precisely maps epigenome in single cells
CUT&Tag speeds process of precisely locating molecules that turn genes on or off
For cells, keeping quiet is a cinch
Researchers show how dormant cells turn genes off by pulling DNA into loops
Dr. Emily Hatch named 2018 Rita Allen Foundation Scholar
She is recognized for her research on the rupture and repair of nuclear membranes that may cause cancer and other diseases
‘Waistbands’ of our chromosomes marked by unusual X-shaped DNA
Human Y chromosome’s center more ‘monkey-like’ than other human chromosomes, study finds