Human Biology Division, Fred Hutch
Public Health Sciences Division, Fred Hutch
Dr. Brian Reid is a world expert in Barrett’s esophagus, or BE, metaplasia caused by acid reflux that is usually benign but, in some patients, can progress to esophageal adenocarcinoma. More generally, Dr. Reid studies how environmental exposures, such as acid reflux or aspirin use, affect progression to cancer by shaping the evolution of cells that carry specific genetic alterations. He founded the Seattle Barrett’s Esophagus Study, also known as the Seattle Study, to better understand who progresses and why. One of the long-standing issues facing BE patients is overtreatment of the many patients who will not progress to cancer, and underdiagnosis of the few who do progress to cancer and need treatment. Dr. Reid’s genetic and genomic research provides insights that will enable doctors to more effectively identify those who are at high risk of progressing from BE to esophageal cancer. These insights could underlie strategies to prevent progression of BE or help doctors intervene when a patient’s tumor is in its earliest, most treatable stages.
Adjunct Professor, Genome Sciences
University of Washington
University of Washington School of Medicine
Ph.D., Genetics, University of Washington, 1975
M.D., University of Washington, 1980