Prostate Cancer Research and Clinical Trials

Fred Hutch Cancer Center researchers are studying ways to prevent prostate cancer, including lifestyle choices that can lower risk. They also seek better methods to screen for the disease, tell which patients will benefit most from treatment and improve treatment results. They are learning how to better tailor care to each patient’s tumor and discovering new targets for therapy.

The Institute for Prostate Cancer Research (IPCR) is a collaboration between Fred Hutch and UW Medicine. Together, this team of more than 40 scientists and providers is studying prostate cancer from many angles. Learn more about the IPCR’s work.

Many breakthroughs in prostate cancer have been made possible by 25 years of research by scientists in the Pacific Northwest Prostate Cancer Specialized Program of Research Excellence (SPORE). It’s a coordinated effort between Fred Hutch, University of Washington and other institutions in British Columbia and Oregon. The National Cancer Institute created the SPORE program to strengthen ties between lab research and patient care and to speed the flow of breakthroughs and insights between them.

Prostate Cancer Clinical Trials 

Fred Hutch typically has over 750 active cancer clinical trials enrolling participants. 

Clinical trials may allow some patients access to a promising new treatment, and help physicians and researchers learn more about a disease. 

Search Prostate Cancer Clinical Trials

Our Areas of Prostate Cancer Research

Some of the many areas of prostate cancer research at Fred Hutch include the following topics. 

Basic Biology of Prostate Cancer

Our scientists are working to better understand the biology of prostate cancer, with a focus on advanced, late-stage prostate cancer. We’re studying how molecular changes in prostate tumors drive the tumors to develop and progress. This may shed new light on ways we can target tumors with treatment.

Precision Oncology Strategies

Our researchers hope to help physicians tailor treatment to each patient and his tumor. To do this, we need more insight into the molecular and genetic changes in prostate tumors and how the changes shape the disease and treatment response. We’re working to discover new tumor vulnerabilities. These could point the way to more effective, individualized care.

Balancing Detection and Treatment

Most men with prostate cancer have slow-growing tumors that don’t need to be treated. But some tumors are deadly, and patients with those tumors benefit from treatment. Our scientists seek to provide oncologists with better tools to tell who’s in which group. Many Fred Hutch investigators study active surveillance or watchful waiting to see who can benefit from this approach.

Risk Factors

Many things can raise or lower your risk for prostate cancer — and perhaps even the risk that cancer will come back after treatment. These include diet, exercise and inherited gene variants. We’re working to find these factors and measure their impact. This information can help improve screening and treatment recommendations for men who are at risk or have already been diagnosed.

Novel therapies

Our physician-scientists are exploring new ways to treat prostate cancer, including with cellular immunotherapies, like STEAP1 CART. In chimeric antigen receptor (CAR) T-cell therapy, a patient’s T-cells (a type of immune cell) are changed in the laboratory so they will attack tumor cells.

Prostate Cancer News

All news
Colorado patient chooses proton therapy following prostate cancer surgery
Colorado patient chooses proton therapy following prostate cancer surgery With no local proton therapy facilities, patient turned to Fred Hutch for its research and reputation December 1, 2025
Lived experience matters: patient engagement improves cancer care, research
Lived experience matters: patient engagement improves cancer care, research Nearly 15 years in, Fred Hutch Patient and Family Engagement Program continues to inform care, expands to match advocates with researchers October 14, 2025
Dr. Yeon Soo Kim receives NIH Pathway to Independence Award
Dr. Yeon Soo Kim receives NIH Pathway to Independence Award Hsieh Lab postdoctoral fellow studies how advanced prostate cancer evades therapy by altering the way RNA builds proteins October 1, 2025
Testing for hereditary cancers can be a lifesaver
Testing for hereditary cancers can be a lifesaver Some people aren’t ready yet, while others believe ‘forewarned is forearmed’ when it comes to cancer-causing genetic variants September 29, 2025

Our Prostate Cancer Researchers and Faculty

Our scientists and providers work together to prevent, diagnose and treat prostate cancer as well as other cancers and diseases. The lab research and clinical research they do are essential parts of the scientific process that leads to new treatments and better care. Clinical trials can also be a way for patients to get early access to new leading-edge therapies. Our research teams are running many clinical studies for people with prostate cancer.

Steven M. Blinka, MD, PhD

Steven M. Blinka, MD, PhD

Steven M. Blinka, MD, PhD

Assistant Professor, Clinical Research Division, Fred Hutch

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Delphine Chen, MD

Delphine Chen, MD

Delphine Chen, MD

Professor, Clinical Research Division, Fred Hutch

Director, Molecular Imaging and Therapy, Fred Hutch

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Heather H. Cheng, MD, PhD

Heather H. Cheng, MD, PhD

Heather H. Cheng, MD, PhD

Professor, Clinical Research Division, Fred Hutch

Clinical Director, Cancer Genetics, Fred Hutch

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Burcu F. Darst, PhD

Burcu F. Darst, PhD

Burcu F. Darst, PhD

Assistant Professor, Public Health Sciences Division, Fred Hutch

Member, Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch

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Ruth Etzioni, PhD

Ruth Etzioni, PhD

Ruth Etzioni, PhD

Professor, Biostatistics Program, Public Health Sciences Division, Fred Hutch

Member, Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch

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Mail Stop: M3-B232
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Ziding Feng, PhD

Ziding Feng, PhD

Ziding Feng, PhD

Professor, Biostatistics Program, Public Health Sciences Division, Fred Hutch

Member, Pathogen-Associated Malignancies Integrated Research Center (PAM IRC)

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Michael Folkert, MD, PhD

Michael Folkert, MD, PhD

Michael Folkert, MD, PhD

Professor, Radiation Oncology Division, Fred Hutch

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Lawrence Fong, MD

Lawrence Fong, MD

Lawrence Fong, MD

Scientific Director, Immunotherapy Integrated Research Center (IIRC), Fred Hutch

Professor, Translational Science and Therapeutics Division, Fred Hutch

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Jie Fu, PhD, DABR

Jie Fu, PhD, DABR

Jie Fu, PhD, DABR

Assistant Professor, Radiation Oncology Division, Fred Hutch

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Clemens Grassberger, PhD

Clemens Grassberger, PhD

Clemens Grassberger, PhD

Associate Professor, Radiation Oncology Division, Fred Hutch

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Michael C. Haffner, MD, PhD

Michael C. Haffner, MD, PhD

Michael C. Haffner, MD, PhD

Associate Professor, Human Biology Division, Fred Hutch

Associate Professor, Clinical Research Division, Fred Hutch

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Andrew Hsieh, MD

Andrew Hsieh, MD

Andrew Hsieh, MD

Professor and Associate Director, Human Biology Division, Fred Hutch

Professor, Clinical Research Division, Fred Hutch

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Dong-Woo Kang, PhD, CEP

Dong-Woo Kang, PhD, CEP

Dong-Woo Kang, PhD, CEP

Assistant Professor, Epidemiology, Public Health Sciences Division, Fred Hutch

Phone: 206.675.5188
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Hiba Khan, MD, MPH

Hiba Khan, MD, MPH

Hiba Khan, MD, MPH

Assistant Professor, Clinical Research Division, Fred Hutch

Member, Hutchinson Institute for Cancer Outcomes Research (HICOR), Fred Hutch

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Haolong Li, PhD

Haolong Li, PhD

Haolong Li, PhD

Assistant Professor, Human Biology Division, Fred Hutch

Member, Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch

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Daniel Lin, MD

Daniel Lin, MD

Daniel Lin, MD

Professor, Cancer Prevention Program, Public Health Sciences Division, Fred Hutch

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Sara Lindstroem, PhD

Sara Lindstroem, PhD

Sara Lindstroem, PhD

Associate Professor, Public Health Sciences Division, Fred Hutch

Member, Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch

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Omar Mian, MD, PhD

Omar Mian, MD, PhD

Omar Mian, MD, PhD

Associate Professor, Human Biology Division, Fred Hutch

Associate Professor, Precision Radiation Sciences Lead, Radiation Oncology Division, Fred Hutch

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Rosa Nadal Rios, MD, PhD

Rosa Nadal Rios, MD, PhD

Rosa Nadal Rios, MD, PhD

Associate Professor, Clinical Research Division, Fred Hutch

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Peter Nelson, MD

Peter Nelson, MD

Peter Nelson, MD

Vice President, Precision Oncology, Fred Hutch

Director, Stuart and Molly Sloan Precision Oncology Institute, Fred Hutch

8 more appointments

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Marian L. Neuhouser, PhD, RD

Marian L. Neuhouser, PhD, RD

Marian L. Neuhouser, PhD, RD

Professor, Public Health Sciences, Fred Hutch

Program Head, Cancer Prevention Program, Public Health Sciences Division, Fred Hutch

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Ruben Raychaudhuri, MD

Ruben Raychaudhuri, MD

Ruben Raychaudhuri, MD

Assistant Professor, Clinical Research Division, Fred Hutch

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Paul Riviere, MD

Paul Riviere, MD

Paul Riviere, MD

Assistant Professor, Radiation Oncology Division, Fred Hutch

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Michael Schweizer, MD

Michael Schweizer, MD

Michael Schweizer, MD

Professor, Clinical Research Division, Fred Hutch

Member, Immunotherapy Integrated Research Center (IIRC), Fred Hutch

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Janet L. Stanford, PhD, MPH

Janet L. Stanford, PhD, MPH

Janet L. Stanford, PhD, MPH

Professor Emeritus, Epidemiology, Public Health Sciences Division, Fred Hutch

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Jamie Takayesu, MD

Jamie Takayesu, MD

Jamie Takayesu, MD

Assistant Professor, Radiation Oncology Division, Fred Hutch

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Valeri Vasioukhin, PhD

Valeri Vasioukhin, PhD

Valeri Vasioukhin, PhD

Professor Emeritus, Human Biology Division, Fred Hutch

Affiliate Professor Emeritus, Basic Sciences Division, Fred Hutch

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Jonathan L. Wright, MD, MS, FACS

Jonathan L. Wright, MD, MS, FACS

Jonathan L. Wright, MD, MS, FACS

Associate Professor, Public Health Sciences Division, Fred Hutch

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Evan Ya-Wen Yu, MD

Evan Ya-Wen Yu, MD

Evan Ya-Wen Yu, MD

Section Head, Medical Oncology, Clinical Research Division, Fred Hutch

Professor, Clinical Research Division, Fred Hutch

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