The overarching goals of the Translational Research Program are to discover and translate molecular and epidemiological findings. To achieve our goals we conduct research in the laboratory and in the clinic. Our laboratory research is aimed at advancing our understanding of the biological basis for various exposure-disease relationships. Our clinical efforts are focused For improved risk assessment, early disease detection, prognostication, treatment decision making and survivorship.
We strive to help the implementation of personalized medicine or the tailoring of specialized and individualized treatment to the specific characteristics of the disease. In practice, this means using molecular profiles of tissue or blood samples to accurately predict a person's susceptibility of developing disease, the presence of disease, disease prognosis and its response to different treatments.
Our researchers discover and validate novel early-detection biomarkers for multiple cancers including breast, colorectal, lung, ovarian, and pancreatic cancers
Current efforts include the discovery and validation of transcriptomic and genomic predictors of cancer progression and survival, as well as the effects of diet and lifestyle on biomarkers of cancer susceptibility.
Faculty use multiple approaches to explore cancer pathogenesis and progression, including the use of mouse models, cell cultures, and mitochondrial DNA.
Several faculty members are focused on advancing our understanding of cancer metastasis and tumor dormancy through in vitro, in vivo and human studies.
Several novel technologies have been developed by program faculty to advance translational cancer research, including the development of bead-based ELISA assays; the Random Mutation Capture (RMC) assay; high density antibody arrays for high throughput proteomic, glycomic and autoantibody biomarker discovery; technology for interrogating the metabolome; and high-throughput sequencing approaches to characterize the gut microbial community.
Translational Research Program
Fred Hutchinson Cancer Research Center
1100 Fairview Ave. N.
Mail Stop M5-A864
PO Box 19024
Seattle, WA 98109-1024