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Clinical Trial Details
TL-895 and KRT-232 Study in Acute Myeloid Leukemia
Complete Title: An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of TL-895 Combined with KRT-232 in Subjects with Relapsed/Refractory (R/R) FLT3+ Acute Myeloid Leukemia (AML)
Trial Phase: I/II
Investigator: Mary-Elizabeth Percival
This study evaluates TL-895, a potent, orally available and highly selective irreversible tyrosine kinase inhibitor combined with KRT-232, a novel oral small molecule inhibitor of MDM2 for the treatment of adults with FLT3 mutated Acute Myeloid Leukemia. Participants must be relapsed/refractory (e.g., having failed prior therapy) to be eligible for this study.
Keywords:
- Leukemia, Acute Myeloid (AML)
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Adult
I/II
Mary-Elizabeth Percival
RG1121360
NCT04669067
An Open-Label, Multicenter, Phase 1b/2 Study of the Safety and Efficacy of TL-895 Combined with KRT-232 in Subjects with Relapsed/Refractory (R/R) FLT3+ Acute Myeloid Leukemia (AML)
Leukemia, Acute Myeloid (AML)