Personalized Neo-Antigen Peptide Vaccine for the Treatment of Stage IIIC-IV Melanoma or Hormone Receptor Positive Her2 Negative Metastatic Refractory Breast Cancer

Complete Title: PNV21-001: A Phase I Study of a Personalized Multi-Peptide Neo-Antigen Vaccine in breast cancer and PD1/PD-L1 Inhibitor Refractory Melanoma

Trial Phase: I

Investigator: Joshua Veatch

This phase I trial studies the safety of personalized neo-antigen peptide vaccine in treating patients with stage IIIC-IV melanoma or hormone receptor positive Her2 negative breast cancer that has spread to other places in the body (metastatic) or does not respond to treatment (refractory). Personalized neo-antigen peptide vaccine is a product combines multiple patient specific neo-antigens. Given personalized neo-antigen peptide vaccine together with Th1 polarizing adjuvant poly ICLC may induce a polyclonal, poly-epitope, cytolytic T cell immunity against the patient`s tumor.

Keywords:

Breast Cancer
Ovarian Cancer

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