Pediatric MATCH: Trk Inhibitor LOXO-101 in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions

Complete Title: APEC1621 NCI-COG PEDIATRIC MATCH (MOLECULAR ANALYSIS FOR THERAPY CHOICE)- PHASE 2 SUBPROTOCOL OF LOXO-101 (LAROTRECTINIB) IN PATIENTS WITH TUMORS HARBORING ACTIONABLE NTRK FUSIONS

Trial Phase: II

Investigator: Navin Pinto

This phase II trial studies Trk inhibitor LOXO-101 in treating patients with solid tumors, non-Hodgkin lymphoma, or histiocytic disorders with NTRK fusions that have spread to other places in the body and have come back or do not respond to treatment. Trk inhibitor LOXO-101 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Keywords:

Central Nervous System (CNS)
Glioma
Hematologic Malignancies
Histiocytosis
Lymphoma
Lymphoproliferative Disorders
Medulloblastoma
Pediatric Cancers, Miscellaneous
Neuroblastoma
Lymphoma, Non-Hodgkin (NHL)
Neuroectodermal Tumors, Primitive (PNET)
Sarcoma
Solid Tumors
Wilms' Tumor
Neoplasms, Germ Cell and Embryonal
Immunoproliferative Disorders
Neuroectodermal Tumors
Ependymoma
Rhabdomyosarcoma
Sarcoma, Ewing
Neoplasms, Neuroepithelial
Osteosarcoma
Neoplasms, Connective and Soft Tissue
Immune System Diseases
Rhabdoid Tumor
Nervous System Diseases
Histiocytosis, Langerhans-Cell
Hepatoblastoma
Neuroectodermal Tumors, Primitive, Peripheral

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