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Clinical Trial Details
GDC-0084 With Radiation Therapy for People With PIK3CA-Mutated Solid Tumor Brain Metastases or Leptomeningeal Metastases
Complete Title: A phase 1 study with expansion cohort of concurrent GDC-0084 with radiation therapy for patients with solid tumor brain metastases or leptomeningeal metastases harboring PI3K pathway mutations
Trial Phase: I
Investigator: Jonathan Yang
This study will test the safety of the study drug, GDC-0084, in combination with radiation therapy in people who have solid tumor brain metastases or leptomeningeal metastases. All participants will have cancer with a PIK3CA mutation. The researchers will test increasing doses of GDC-0084 to find the highest dose that causes few or mild side effects in participants. The study will also try to find out if the combination of the study drug with radiation is effective against participants` cancer.
Keywords:
- Brain Cancer
- Neoplasm Metastasis
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Adult
I
Jonathan Yang
RG1123050
NCT04192981
A phase 1 study with expansion cohort of concurrent GDC-0084 with radiation therapy for patients with solid tumor brain metastases or leptomeningeal metastases harboring PI3K pathway mutations
Brain Cancer
Neoplasm Metastasis