Carvedilol in Preventing Heart Failure in Childhood Cancer Survivors

Complete Title: Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Heart Failure (PREVENT-HF): A Phase 2b Randomized Placebo-Controlled (Carvedilol) Trial.

Trial Phase: II

Investigator: Eric Chow, MD

This randomized phase IIb trial studies how well low-dose carvedilol works in preventing heart failure in cancer survivors exposed to high dose anthracyclines for management of childhood cancer. Patients who received high-dose anthracycline chemotherapy are at a much greater risk for developing heart failure compared to survivors who didn't get any anthracycline chemotherapy. Heart failure happens when the heart muscle has been weakened and can't pump blood as well as it should. Carvedilol may help lower the risk of cardiovascular complications.

Keywords:

Hematologic Malignancies
Pediatric Cancers, Miscellaneous
Solid Tumors
Cardiovascular Diseases
Cancer Survivor
Heart Failure
Heart Diseases

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