Cabozantinib With Radiation Therapy for the Treatment of Sarcomas of the Extremities

Complete Title: A Phase 1/2 Study of Neoadjuvant Cabozantinib in Combination with Radiation Therapy for Sarcomas of the Extremities
Trial Phase: I/II
Investigator: Lee Cranmer

This phase I/II trial studies the side effects and best dose of cabozantinib when given with radiation therapy and how well it works in treating patients with sarcoma of the extremities. Cabozantinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Giving cabozantinib with radiation therapy may make the tumors smaller and reduce the amount of normal tissue that needs to be removed.

Keywords:
  • Sarcoma
  • Sarcoma, Soft Tissue
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Adult
I/II
Lee Cranmer
RG1003562
NCT04220229
A Phase 1/2 Study of Neoadjuvant Cabozantinib in Combination with Radiation Therapy for Sarcomas of the Extremities
Sarcoma
Sarcoma, Soft Tissue