Anti-CD137 and Anti-CTLA-4 Monoclonal Antibody in Patient With Advanced Cancer

Complete Title: A Phase 1 Study of AGEN2373, an Anti-CD137 Monoclonal Antibody, as Monotherapy and in Combination with AGEN1181, an Fc-engineered Anti-CTLA-4 Monoclonal Antibody, in Patients with Advanced Cancer
Trial Phase: I
Investigator: Shailender Bhatia, MD

This study is an open-label, Phase 1, multicenter study to evaluate the safety, tolerability, PK, and PD profiles of AGEN2373 as a monotherapy and in combination with AGEN1181, and to assess the maximum tolerated dose (MTD) in subjects with advanced solid tumors.

Keywords:
  • Neoplasms, Advanced Malignant
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Adult
I
Shailender Bhatia, MD
RG1122190
NCT04121676
A Phase 1 Study of AGEN2373, an Anti-CD137 Monoclonal Antibody, as Monotherapy and in Combination with AGEN1181, an Fc-engineered Anti-CTLA-4 Monoclonal Antibody, in Patients with Advanced Cancer
Neoplasms, Advanced Malignant