Adjuvant Avelumab in Merkel Cell Cancer (ADAM)

Complete Title: A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Phase 3 Trial of Adjuvant Avelumab (anti-PDL-1 antibody) in Merkel Cell Carcinoma Patients with Lymph Node Metastases
Trial Phase: III
Investigator: Shailender Bhatia

This randomized phase III trial studies how well avelumab works in treating patients with Merkel cell cancer that has spread to the lymph nodes and have undergone surgery with or without radiation therapy. Monoclonal antibodies, such as avelumab, may stimulate the immune system and interfere with the ability of tumor cells to grow and spread.

Keywords:
  • Solid Tumors
  • Neoplasms, Germ Cell and Embryonal
  • Neuroendocrine Tumor
  • Virus Diseases
  • Neuroectodermal Tumors
  • Neoplasms, Glandular and Epithelial
  • Neoplasms, Nerve Tissue
  • Adenocarcinoma
  • Carcinoma
  • Carcinoma, Merkel Cell
  • Carcinoma, Neuroendocrine
  • Polyomavirus Infections
  • DNA Virus Infections
  • Tumor Virus Infections
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Adult
III
Shailender Bhatia
9820
NCT03271372
A Multicenter, Randomized, Double-Blinded, Placebo-Controlled, Phase 3 Trial of Adjuvant Avelumab (anti-PDL-1 antibody) in Merkel Cell Carcinoma Patients with Lymph Node Metastases
Solid Tumors
Neoplasms, Germ Cell and Embryonal
Neuroendocrine Tumor
Virus Diseases
Neuroectodermal Tumors
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Adenocarcinoma
Carcinoma
Carcinoma, Merkel Cell
Carcinoma, Neuroendocrine
Polyomavirus Infections
DNA Virus Infections
Tumor Virus Infections