A Study of NX-1607 in Adults With Advanced Malignancies

Complete Title: A Phase 1a, Dose Escalation, Safety and Tolerability Study of NX-1607, a Casitas B-lineage lymphoma proto-oncogene (CBL-B) inhibitor, in Adults with Advanced Malignancies, with Phase 1b Expansion in Select Tumor Types
Trial Phase: I
Investigator: John Liao

This is a first-in-human Phase 1a/1b multicenter, open-label oncology study designed to evaluate the safety and anti-cancer activity of NX-1607 in patients with advanced malignancies.

Keywords:
  • Gastric Cancer
  • Head and Neck Cancer
  • Melanoma
  • Mesothelioma
  • Ovarian Cancer
  • Lung Carcinoma, Non-Small-Cell (NSCLC)
  • Prostate Cancer, Castration-resistant (CRPC)
  • Colorectal Neoplasms
  • Lymphoma, Large B-Cell, Diffuse
  • Triple Negative Breast Neoplasms
  • Urothelial Cancer
  • Gastroesophageal Junction Cancer
  • Richter Syndrome
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Adult
I
John Liao
RG1123233
NCT05107674
A Phase 1a, Dose Escalation, Safety and Tolerability Study of NX-1607, a Casitas B-lineage lymphoma proto-oncogene (CBL-B) inhibitor, in Adults with Advanced Malignancies, with Phase 1b Expansion in Select Tumor Types
Gastric Cancer
Head and Neck Cancer
Melanoma
Mesothelioma
Ovarian Cancer
Lung Carcinoma, Non-Small-Cell (NSCLC)
Prostate Cancer, Castration-resistant (CRPC)
Colorectal Neoplasms
Lymphoma, Large B-Cell, Diffuse
Triple Negative Breast Neoplasms
Urothelial Cancer
Gastroesophageal Junction Cancer
Richter Syndrome