A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers (COMBINE-EGFR-1)

Complete Title: A PHASE 1/2 STUDY OF REGN7075 (EGFRxCD28 COSTIMULATORY BISPECIFIC ANTIBODY) IN COMBINATION WITH CEMIPLIMAB IN PATIENTS WITH ADVANCED SOLID TUMORS
Trial Phase: I/II
Investigator: Cristina Rodriguez

This study is researching an investigational drug called REGN7075 by itself and in combination with cemiplimab with or without chemotherapy. The study is focused on patients with certain solid tumors that are in an advanced stage. The aim of the study is to see how safe and tolerable REGN7075 is by itself and in combination with cemiplimab (with or without chemotherapy), and to find out what is the best dose of REGN7075 to be given to patients with advanced solid tumors when combined with cemiplimab (with or without chemotherapy). Another aim of the study is to see how effective REGN7075 by itself, or in combination with cemiplimab (with or without chemotherapy), is at treating cancer patients. The study is also looking at: Side effects that may be experienced by people taking REGN7075 by itself and in combination with cemiplimab with or without chemotherapy How REGN7075 works in the body by itself and in combination with cemiplimab with or without chemotherapy How much REGN7075 is present in the blood when given by itself and in combination with cemiplimab with or without chemotherapy To see if REGN7075 by itself and in combination with cemiplimab with or without chemotherapy works to treat cancer by controlling the proliferation of tumor cells to shrink the tumor

Look up Trial at NIH
Keywords:
  • Advanced Solid Tumors
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