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Patient Guide to Clinical TrialsDALY II USA/? MB-CART2019.1 for DLBCL
Complete Title: A multi-center single arm Phase II study to evaluate the safety and efficacy of genetically engineered autologous cells expressing anti-CD20 and anti-CD19 specific chimeric antigen receptor in subjects with relapsed and/or refractory diffuse large B cell lymphoma
Trial Phase: II
Investigator: Jordan Gauthier
DALY II USA is a phase II, multi-center, single arm study to evaluate the efficacy, safety, and pharmacokinetics of zamtocabtagene autoleucel (MB-CART2019.1) in patients with relapsed and/or refractory diffuse large B cell lymphoma (DLBCL) after receiving at least two lines of therapy. Additional cohorts include subjects with B-cell primary or secondary central nervous system (CNS) lymphoma (PCNSL) and (SCNSL), mantle cell lymphoma (MCL) and Richter`s transformation (RT) after receiving at least one line of therapy.
Keywords:
- Central Nervous System (CNS); Lymphoma; Lymphoma, Mantle-Cell; Richter Syndrome
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