A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

Complete Title: An Open Label, Multicenter, Dose Escalation, Dose Expansion Phase 1/2 Study with PT217 adapted to include the ChecKpoint inhibitor Atezolizumab as a Phase 2 Study in combination with PT217 in patients with Small Cell Lung Carcinomas and Extrapulmonary Neuroendocrine cancers that are known to be DLL3 expressing cancers
Trial Phase: I/II
Investigator: Ruben Raychaudhuri

This is a first-in-human, Phase 1/2, open-label, dose escalation, dose expansion and combination study designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and preliminary efficacy of Peluntamig (PT217) as a monotherapy and in combination with chemotherapy.

Look up Trial at NIH
Keywords:
  • Neuroendocrine Tumor; Lung Carcinoma, Small-Cell
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