Clinical Trial Details

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

Complete Title: HERTHENA-PanTumor01 (U31402-277): A Phase 2, Multicenter, Multicohort, Open-Label, Proof of Concept Study of Patritumab Deruxtecan (HER3-DXd; U3-1402) in Subjects with Locally Advanced or Metastatic Solid Tumors
Trial Phase: II
Investigator: Andrew Coveler

This is a proof-of-concept study designed to investigate HER3-DXd monotherapy in locally advanced or metastatic solid tumors. The study is enrolling cohorts of participants with melanoma [cutaneous/acral], squamous cell carcinomas of the head and neck (SCCHN), and HER2-negative gastric cancerovarian carcinoma, cervical cancer, endometrial cancer, bladder cancer, esophageal carcinoma, pancreatic carcinoma, and prostate cancer.

Keywords:
  • Head and Neck Cancer; Melanoma; Ovarian Cancer; Pancreatic Cancer; Prostate Cancer; Advanced Solid Tumors; Bladder Cancer; Cervical Cancer; Endometrial Cancer; Esophageal Cancer; Gastric Cancer
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