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Patient Guide to Clinical TrialsDonor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies
Complete Title: Hematopoietic Stem Cell Transplantation from Haploidentical Donors in Patients with Hematological Malignancies Using a Treosulfan-Based Preparative Regimen
Trial Phase: II
Investigator: Filippo Milano
This phase II trial studies how well a donor stem cell transplant, treosulfan, fludarabine, and total-body irradiation work in treating patients with blood cancers (hematological malignancies). Giving chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient`s immune system from rejecting the donor`s stem cells. When the healthy stem cells from a donor are infused into the patient, they may help the patient`s bone marrow make stem cells, red blood cells, white blood cells, and platelets. The donated stem cells may also replace the patient`s immune cells and help destroy any remaining cancer cells.
Keywords:
- Lymphoma, Marginal Zone; Lymphoma, Mantle-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Follicular; Lymphoma, Small Lymphocytic (SLL); Leukemia, Prolymphocytic; Lymphoma, Lymphoblastic (LBL); Leukemia, Acute Lymphoblastic (ALL); Leukemia, Acute Myeloid (AML); Lymphoma, Burkitt; Lymphoma, Hodgkin; Myelodysplastic Syndromes (MDS); Leukemia, Lymphoid
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