Hans-Peter Kiem, MD, PhD

Hans-Peter Kiem, MD, PhD

Hans-Peter Kiem, MD, PhD

  • Physician, Fred Hutchinson Cancer Center
  • Professor, Translational Science and Therapeutics Division, Fred Hutch
  • Stephanus Family Endowed Chair for Cell and Gene Therapy, Fred Hutch
  • Associate Head, Hematological Malignancies Program, Fred Hutch/University of Washington/Seattle Children's Cancer Consortium
  • Professor, Division of Hematology and Oncology, University of Washington School of Medicine
  • Adjunct Professor of Pathology, University of Washington School of Medicine


“If we can correct defective stem cells, we can cure diseases.”

— Dr. Kiem

What intrigues you as a physician and researcher?

I’ve always been fascinated by the science of bone marrow transplantation — the fact that stem cells could take hold in someone and aid the functioning of their blood cells for a lifetime. During medical school in Germany, I often heard about Dr. E. Donnall Thomas, who won a Nobel Prize for developing the bone marrow transplant, and other people at Fred Hutchinson Cancer Research Center. In 1992, I was fortunate enough to start a fellowship there; I got to meet all those people I’d been hearing about, and it was an amazing experience! Studying with Dr. Rainer Storb, I wanted to better understand stem cells so we could fix the diseases that affect them — and that’s been the center of my research ever since.

Is there a patient who has had a deep impact on you?

Charlie Burgess is a man I will never forget. One Fourth of July, he was celebrating with family and friends when they noticed that he seemed disoriented. At the ER, he found out he had a glioblastoma, an aggressive form of brain cancer. His prognosis was poor, but he really wanted to fight, and not just for himself, but for his family: his wife and his daughter, who was still in high school. Charlie became the first patient on our gene therapy trial for glioblastomas. He responded really well, surviving for several years. He got to see his daughter graduate from college, which was huge. Throughout the remainder of his life, we stayed close. It was so rewarding to be able to help him.

Provider Background

Area of Clinical Practice
Cellular immunotherapy

Hematopoietic stem cell transplantation, gene therapy, graft-versus-host disease, cellular immunotherapy

I am a medical oncologist who specializes in stem cell and bone marrow transplantation for patients with blood cancers. In 2018, I was awarded the Stephanus Family Endowed Chair for Cell and Gene Therapy at Fred Hutchinson Cancer Research Center. I have extensive experience training students and postdoctoral fellows, having mentored more than 50 trainees over the past 20 years.

My research investigates how stem cells can be extracted from patients, manipulated at a genetic level and then delivered back to them to treat diseases ranging from cancers to genetic conditions like sickle cell disease to infections like HIV. Currently, I am sponsoring four clinical gene therapy studies; one of these studies is the first of its kind to use this stem-cell approach to fix a gene involved with Fanconi anemia, a rare blood disorder that often leads to leukemia and other cancers. In addition to caring for patients and conducting research, I also serve as chair of the American Society for Gene and Cell Therapy’s Stem Cell Committee and the American Society of Hematology’s Stem Cell Committee.



Education, Experience and Certifications

Medical Degree
University of Ulm

Vanderbilt University

Stanford University; University of Washington/Fred Hutchinson Research Center

Board Certification
Medical Oncology, 1997; Internal Medicine, 1993, American Board of Internal Medicine


All news
Dr. Hans-Peter Kiem awarded amfAR grant for research on HIV gene therapy Potential cure builds on unexpected findings about hematopoietic stem cells August 2, 2023
Eight Fred Hutch teams win Evergreen Fund awards Research projects with commercial partnership potential receive grants of up to $200K December 13, 2022
Fred Hutch hosts inaugural Dr. E. Donnall Thomas Symposium Event draws leading researchers in transplantation, gene and cell therapy October 7, 2022

Clinical Trials

We make promising new treatments available to you through studies called clinical trials led by Fred Hutch physicians. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your physician can decide if a study is right for you. 

Find a Clinical Trial Led by Dr. Kiem


Many of our Fred Hutch physicians conduct ongoing research to improve standards of patient care. Their work is evaluated by other physicians and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch physician has written. 

View Dr. Kiem's Publications

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