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Mian
Omar Mian, MD, PhD

Omar Mian, MD, PhD

Radiation Oncology

  • Physician, Fred Hutch
  • Associate Professor, Human Biology Division, Fred Hutch
  • Associate Professor, Precision Radiation Sciences Lead, Radiation Oncology Division, Fred Hutch
  • Associate Professor, Department of Radiation Oncology, University of Washington School of Medicine

About

Dr. Omar Mian is a radiation oncologist and scientist at Fred Hutch. He specializes in cancers of the genitourinary tract and researches how to understand and improve treatment for these diseases.


Background

Dr. Mian primarily treats patients with bladder, prostate and kidney cancer using radiation therapy and works to tailor care for both early‑stage and more advanced disease.

In his lab, Dr. Mian studies the genetics and molecular features of genitourinary cancers. His work examines how changes in genes and gene expression allow cancers to progress from early stage, potentially curable forms to more aggressive and treatment‑resistant disease. A central goal of his research is to better understand this progression to identify opportunities to reverse it, develop targeted therapies and reduce resistance to treatment.

Dr. Mian’s lab analyzes leading-edge medical imaging techniques that track disease progression and studies tumor samples from patients whose cancers have survived radiation therapy. His team also uses cell‑based and animal models to study the biology and evolution of common and rare genitourinary cancers. He also studies how nuclear hormone receptors influence DNA repair and resistance to chemotherapy and radiation, helping to identify biological signs of aggressive disease where new treatment approaches are needed.

Area of Clinical Practice
Radiation oncology, clinical research


“I care a lot about each patient and their experience when they see me. The science behind cancer medicine is at the core of everything we do, and I’m very passionate about that part as well.”

— Dr. Mian


What do you hope it’s like for a patient to work with you?

The most important thing to me is that patients trust me and feel like they have a compassionate caregiver.

I hope they feel that I genuinely care for them and am accessible to them. When they have questions, doubts or don't understand something, I am always available to explain something to them. I want people to feel like they're involved in every aspect of their care, not like what's happening to them is a mystery. 

I also want them to feel hopeful and to have the sense that no matter what the situation looks like, there are always things we can do to help.

What do you value about your work?

In recent years, I feel like I’ve finally gotten to the point in my laboratory life and career where some of the work we’re doing is moving through clinical trials and studies and into the clinic. This is enormously rewarding. We know there are gaps in what we can treat and areas where we don’t have as many options as we would like to offer patients, but we are working collaboratively to address this. 

Diseases Treated

Research Interests

Molecular mechanisms underlying prostate and bladder cancer initiation, progression, and therapeutic resistance

Interplay between hormone receptor signaling and radiation resistance in prostate cancer

Mechanisms responsible for the transition from androgen-responsive prostate and bladder cancer to small-cell/neuroendocrine cancer

New and emerging radiotherapy delivery technologies, including targeted stereotactic ablative radiation, particle therapy (e.g., proton, neutron, radiopharmaceuticals), and dose rate modulation (e.g., FLASH)

Languages

English

Education and Experience

Residency, Radiation Oncology, Johns Hopkins Hospital

Internship, Internal Medicine, Virginia Commonwealth University

MD, Virginia Commonwealth University School of Medicine

PhD, Virginia Commonwealth University School of Medicine

Undergraduate Degree, James Madison University

Board Certifications

Radiation Oncology, 2017; American Board of Radiology

Awards

National Comprehensive Cancer Network (NCCN) Young Investigator Award, 2021

Society for Basic Urologic Research (SBUR) Young Investigator Award, 2021

American Cancer Society Research Scholar Award, 2021

Cleveland Clinic Foundation Radiation Oncology Educator of the Year, 2019

Clinical Trials

We make promising new treatments available to you through studies called clinical trials led by Fred Hutch physicians and researchers. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your physician can decide if a study is right for you.

View Clinical Trials

Publications

Many of our Fred Hutch physicians and researchers conduct ongoing research to improve standards of patient care. Their work is evaluated by others in their field and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch physician has written.

View Dr. Mian's Publications

Your Care Team

At Fred Hutch, you receive care from a team of providers with extensive experience in your disease. Your team includes physicians, a patient care coordinator, a registered nurse, an advanced practice provider and others, based on your needs. You also have access to experts like registered dietitians, social workers, acupuncturists, psychiatrists and more who specialize in supporting people with cancer or blood disorders.

Insurance

Fred Hutch accepts most national private health insurance plans as well as Medicare. We also accept Medicaid for people from Washington, Alaska, Montana and Idaho. We are working to ensure that everyone, no matter what their financial situation, has access to the care they need.

Stories

All news
The Beam: Good news for head and neck cancer patients, updates on FLASH proton therapy, meet a passionate radiation oncologist Dr. Jay Liao explains results from promising studies in the head and neck cancer world, research continues into FLASH proton therapy, meet Ben Li, MD April 1, 2026

Contact Information