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Jiang
Yuyan Jiang, PhD
- Assistant Professor, Human Biology Division, Fred Hutch
- Assistant Professor, Radiation Oncology Division, Fred Hutch
- Assistant Professor, Department of Radiation Oncology, University of Washington School of Medicine
About
Dr. Yuyan Jiang is a biomedical engineer who creates molecular tools for cancer treatment that remove disease-causing proteins and deliver gene-editing and RNA medicines to specific cells. Her research aims to create safer, more precise and more effective treatments for cancer and other diseases.
Background
Dr. Jiang’s research focuses on developing molecular tools that give doctors new ways to treat cancer and other diseases with greater precision and fewer side effects. During her postdoctoral training at Stanford School of Medicine, she developed a way to deliver therapies that boost the immune system by using tiny gold particles that are eventually cleared from the body through normal metabolism. The therapies silence harmful genes and make tumors more sensitive to radiation.
She also worked with collaborators to develop a new type of therapy called lysosome-targeting chimeras, or LYTACs that help cells identify and destroy disease-related proteins that have traditionally been difficult or impossible to target with drugs.
Her research team integrates chemistry, bioengineering and cancer biology to create more precise treatments.
Research Focus
The Jiang Lab develops programmable molecular systems with translational potential for cancer theranostics. We are especially excited to pursue three major directions:
- Lysosomal targeting chimeras (LYTACs) as next-generation therapeutics for advanced cancer therapies.
- Bioresponsive matrices for targeted gene regulation and radiodynamic therapy.
- Ultrasensitive molecular probes for biomarker detection and early disease diagnosis. Our goal is to build molecular technologies that can enable more precise, responsive, and effective approaches to cancer detection and treatment.
Education and Experience
PhD, Chemical and Biomedical Engineering, Nanyang Technological University
BEng, Chemistry and Chemical Engineering, Sun Yat-Sen University