"Cures Start Here"

Phase 1 Program

Contact Us

Phone: 206.606.7551
Email: phase1clinicaltrial@seattlecca.org
Fax: 206.606.6681

Mailing Address

825 Eastlake Ave. E.
Mailstop CE2-102
Seattle, WA  998109-1023

Fred Hutchinson Cancer Center treats each patient with the best care possible. Sometimes, that involves a clinical trial. 

Our Phase 1 clinical trials offer an option to people with advanced cancer when conventional treatments no longer work. These trials, which study innovative new therapies in people for the first time, are critical to future patients, who may benefit from today’s breakthroughs, and to the health care industry, which is searching for tomorrow’s cures.

Leading researchers and cancer experts from Fred Hutch and the UW Medicine partner as one team devoted to your best possible outcome.

Mission Statement

The Phase I Program partners with patients and families to conduct-cutting edge cancer research for the advancement of science. Our clinical trial expertise allows us to inspire hope and provide compassionate care for those who face a lack of treatment options. We collaborate with our Cancer Consortium and leading industry partners to improve quality care for current and future generations.

Phase 1 Program Capabilities

Fred Hutch provides the first academic-based Phase 1 program for cancer research in the Pacific Northwest. 

Phase I clinical trials require a high level of technical and scientific competencies, like those found at Fred Hutch. Our program provides unique opportunities for correlative studies that take advantage of our consortium’s research strengths, such as world-class positron emission tomography (PET) imaging, proteomics, biomarkers and genomics cores.

Research Services We Provide

The Phase 1 Program provides a full range of research services to advance the development, implementation and successful completion of clinical trials.

  • The test agents that we study include immune-modifying agents such as antibodies to immune checkpoints, small molecules that target cancer-causing mutations, antibody/drug conjugates, agents that target the immune microenvironment and vasculature, and other targets. We partner with pharmaceutical companies to move promising agents from pre-clinical development to early-phase trials in patients with cancer. 
  • Regulatory review (such as for the safety of study participants) includes scientific committee review, radiation safety review and institutional review board (IRB) review.
  • We have experience conducting outpatient trials at Fred Hutch - South Lake Union and inpatient trials at UW Medical Center - Montlake.

Clinical Trials Unit

We created our Clinical Trials Unit with the highest level of quality and comfort for our patients. Features include:

  • A lounge with comfortable chairs, a flat-panel television and snacks to create a peaceful environment.
  • Four patient rooms where each patient can receive care in one place, with nursing staff and research coordinators close by.

The Clinical Trials Unit is open from Monday through Friday, 8 am to 10 pm. If an overnight stay is required, our patients stay at UW Medical Center - Montlake.

Phase 1 Program Team

Our highly skilled and devoted staff, nurses and physicians have extensive research experience and provide the exacting care and attention required to test potential breakthrough therapies.

John A. Thompson, MD

Director, Phase 1 Clinical Trials Program, Fred Hutch
Member, Clincial Research Division, Fred Hutch
Professor, Medical Oncology Division, University of Washington

Bojana I. Askovich, PhD

Phase 1, Program Administrator, Fred Hutch
Principal Research Scientist, Fred Hutch
  • Hannah Lee, CCRC, Senior Research Manager
  • Harini Ramachandran, Principal Research Coordinator
  • Olga Tsvetkova, Senior Research Coordinator
  • Elizabeth Liu, Research Coordinator
  • Catherine Ashley, Research Coordinator
  • Chi Westerhold, Senior Research Coordinator
  • LyTieng Huot, Research Coordinator
  • Amanda Ramsing-Lund, Research Coordinator
  • Audrey McCarthy, Research Coordinator
  • Morgan Kauss, Research Coordinator
  • Alise Quynh-Huong Vu, Research Coordinator
  • Fanqi Shi, Research Coordinator
  • Danika Anderson, Research Coordinator
  • Jeniece Hensel, CCRP, Senior Research Data Manager
  • Meghan Laurie, CCRP, Assistant Data Manager
  • Alice Tran, Senior Data Coordinator
  • Ella Hileman-Kaplan, Data Coordinator
  • Megan Omoto, Data Coordinator
  • Sophia Gould, Data Coordinator
  • Caroline McKewan, Data Coordinator
  • Sydney Burns, Research Study Assistant
  • Meagan Tumy, Student Assistant
  • Reina Hibbert, CCRC, Principal Regulatory Affairs Manager
  • Patrick Toler, Principal Regulatory Affairs Coordinator
  • Jordan Cooper, Senior Regulatory Affairs Coordinator 
  • Sarah Beasley, Regulatory Coordinator
  • Sarah Lampert, Regulatory Coordinator
  • Rajee Pandey, Regulatory Research Assistant
  • Emily Basom, Student Assistant
  • Kaya Schroeder, Student Assistant
  • Lee Lee Lim, Business Manager
  • Cassie Kim, Study Start-up Manager
  • Gergana Bozhilova-Deneva, Budget Fiscal Analyst
  • Gurleen Chaddha, Clinical Research Operations Specialist
  • Tien Nguyen, Budget Fiscal Analyst
  • Gabriel Andres, Clinical Trials Budget Coordinator
  • Sanya Cheeti, Student Assistant
  • John Thompson, MD (melanoma and renal)
  • Evan Hall, MD (melanoma and renal)
  • Jennifer Specht, MD (breast)
  • Shaveta Vinayak, MD (breast)
  • Rafael Santana-Davila, MD (head, neck and lung)
  • Andrew Coveler, MD (gastrointestinal)
  • Gabi Chiorean, MD (gastrointestinal)
  • Michael Schweizer, MD (genitourinary)
  • Elizabeth Swisher, MD (gynecological)
  • John B. Liao, MD, PhD (gynecological)
  • Banda, MD (gynecological)
  • Ajay Gopal, MD (hematology)
  • Annie Alidina, ARNP
  • Candace Mencias, Clinical Research Nurse Coordinator
  • Kim Sheppard, Clinical Research Nurse Coordinator
  • Mark Samuel, RN
  • Annie Alidina, ARNP
  • Peter Phrydas, Team Coordinator
  • Alina (Gigi) Yesiki, Pilot Pharmacist
  • Sarah Geiler, RN
  • Anneliese Schuessler, Pilot Pharmacist
  • Leslie Blackwell, CORS RN
  • Teresa Mata-Cervantes, CORS RC
  • Michael Peters, Senior Lab Manager
  • Josh Willard, Laboratory Scientist
  • Tim Johnson, Laboratory Scientist
  • Madhu Raman, Student Assistant
  • Minh Ramert, Clinical Trials Unit/ Acute Care Evaluation (ACE) Clinic Nurse Manger
  • Kimberly Ito, Clinical Trials Unit Nursing Supervisor 
  • Anna Stewart, Clinical Trials Unit Clinical Trials Coordinator
  • Nikki Mendoza, Clinical Trials Unit Clinical Trials Coordinator 
  • Rey Bonus, Clinical Trials Unit Clinical Trials Coordinator 

In Memoriam
Dana Snyder, CCRC, Senior Research Coordinator

  1. E. T. Rodler, J. R. Infante, L. L. Siu, D. C. Smith, D. Sullivan, G. Vlahovic, J. Gomez-Navarro, G. Liu, S. Blakemore, J. A. Thompson. First-in-human phase I dose-escalation study of investigational drug MLN9708, a second-generation proteasome inhibitor, in advanced non-hematologic malignancies. Journal of Clinical Oncology 28, no. 15_suppl (May 2010) 3071-3071.
  2. Ansell, SM, Thompson, J, Infante, S, Heath, E, Whiting, N.C., Zhao, B and Forero-Torres, A. Targeting CD70 in Non-Hodgkin Lymphoma and Renal Cell Carcinoma: A Phase 1 Study of the Antibody-Drug conjugate SGN-75.  Annals of Oncology, Volume 21, Issue suppl_8, p532P. (October 2010).
  3. Bhatia S, Hamid O, Pavlick AC, Mulligan G, Smith PG, Pickard MD, Shultz M, Walker RM, Dezube B, O'Day S, MLN4924, an investigational NEDD8-activating enzyme inhibitor, in patients with metastatic melanoma: results of a phase 1 study, 2011, J Clin Oncol 29, abstr 8529.
  4. Konopleva M, Borthakur G, Thall PF, Yi CA,  Coveler A, Bueso-Ramos C, Benito J, Konoplev S, Gu Y, Ravandi F, Jabbour E, Faderl S, Thomas D, Cortes J, Kadia T, Kornblau S, Daver N, Pemmaraju N, Nguyen HQ, Feliu J, Lu H, Wei C, Wilson WR, Melink TJ, Gutheil JC, Andreeff M, Estey EH, Kantarjian H.Phase I/II Study of PR104 in Subjects with Refractory/Relapsed Acute Leukemia using Adaptive Dose Selection. 53 Annual ASH Meeting. 2011.
  5. Munster PN, van der Noll R, Voest EE, Dees EC, Tan AR, Specht JM, Falchook GS, Daud A, Lolkema MP, Grilley-Olson JE, Yu EY, Fu S, Bergeland EK, Kleha J, Peng S, Smith DA, Lampkin TA, Schellens JHM, Morris SR, Kurzrock R, Phase 1 first-in-human study of the PI3 kinase inhibitor GSK2126458 (GSK458) in patients with advanced solid tumors, 2011, J Clin Oncol 29, abstr 3018.
  6. Thompson JA, Forero-Torres A, Heath EI, Ansell SM, Pal SK, Infante JR, De Vos S, Hamlin PA, Zhao B, Klussman K, Whiting NC, The effect of SGN-75, a novel antibody–drug conjugate (ADC), in treatment of patients with renal cell carcinoma (RCC) or non-Hodgkin lymphoma (NHL): A phase I study, 2011, J Clin Oncol 29, abstr 3071.
  7. Rodler ET, Specht JM, Gadi VK, Kurland BF, Griffin MJ, Hammond JJ, Gralow JR, Phase 1 Study of PARP Inhibitor ABT-888 (Veliparib) in Combination with Cisplatin and Vinorelbine for Patients with Advanced Triple Negative Breast Cancer and/or BRCA-Mutation Associated Breast Cancer, 2011, Cancer Res 71; p1-17-04.
  8. Brentuximab Vedotin (SGN-35) Treatment in Relapsed CD30-positive Hodgkin Lymphoma Patients Following Allogeneic Stem Cell Transplant:  A Multicenter Case Series. AK Gopal, R. Ramchandren, RB Berryman, RH Advani, R Chen, SE Smith,  M Cooper, A Engert, J Matous, J Zain, LE Grove, NN Hunder, OA O’Connor. 37th Annual Meeting of the European Group for Blood and Marrow Transplantation. Paris, April 3-6, 2011.
  9. Falchook GS, Goff BA, Kurzrock R, Gray HJ, Martin LP, Coleman RL, Liu H, Zhou X, Benaim E, Schilder R, Phase I/II study of weekly paclitaxel with or without MLN8237 (alisertib), an investigational aurora A kinase inhibitor, in patients with recurrent epithelial ovarian, fallopian tube, or primary peritoneal cancer (OC), or breast cancer (BrC): Phase 1 results, 2012, J Clin Oncol 30, abstr 5021.
  10. Smith DC, Sullivan D, Infante JR, Kauh JS, Siu LL, Vlahovic G, Thompson JA, Gupta J, De Bacco A, Liu G, Kalebic T, MLN9708, an investigational proteasome inhibitor, in patients (pts) with solid tumors: Updated phase I results, 2012, J Clin Oncol 30, abstr e13603.
  11. Tykodi SS, Brahmer JR, Hwu WJ, Chow LQ, Topalian SL, Hwu P, Odunsi K, Camacho LH, Kauh JS, Pitot HC, Hamid O, Pardoll DM, Agrawal S, Parker S, Goldberg S, Gubta AK, Wigginton J, PD-1/PD-L1 pathway as a target for cancer immunotherapy: Safety and clinical activity of BMS-936559, an anti-PD-L1 antibody, in patients with solid tumors, 2012, J Clin Oncol 30, abstr 2510.
  12. Alessandra Di Bacco, Allison Berger, Neeraj Gupta, Feng Gao, Stephen Blakemore, Mark Qian, Susan Chen, Bradley Stringer, Yu Yang, Ray Liu, Stephen Tirrell Doug Bowman, David C. Smith, Daniel Sullivan, Jeffrey R. Infante, John S. Kauh, Lillian L. Siu, Gordana Vlahovic, John A. Thompson, Thea Kalebic.Tumor drug distribution and target engagement of MLN9708, an investigational proteasome inhibitor, in patients with advanced solid tumors.Journal of Clinical Oncology 30, no. 15_suppl (May 2012) 3077-3077.
  13. Chow LQ, Infante JR, Siu LL, Sullivan D, Kauh JS, DiBacco A, Gupta N, Kalebic T, Smith DC, Thompson JA. MLN9708, an investigational proteasome inhibitor, in patients with solid tumors: Updated phase 1 results.  Poster Presentation at the Multidisciplinary Head and Neck Symposium, Phoenix, AZ, 2012.
  14. Bell-McGuinn KM, Gray HJ, Fleming GF, Cristea MC, Medina DM, Xiong H, Dudley MW, Dunbar M, Giranda VL, Luo Y, McKee MD, Martin LP, A Phase I Study of ABT-888 in Combination with Carboplatin and Gemcitabine in Subjects with Advanced Solid Tumors, J Clin Oncol 31, 2013, abstr 2584.
  15. Coveler AL, Van Hoff DD, Ko AH, Whiting NC, Zhao B, Wolpin BM. A phase 1 study of ASG-5ME, a novel antibody:drug conjugate, in pancreatic ductal adenocarcinoma, 2013, J Clin Oncol 31, abstr 176
  16. Hingorani SR, Harris WP, Beck JT, Berdov BA, Wagner SA, Pshevlotsky EM, Tjulandin S, Gladkov O, Holcombe RF, Jiang P, Maneval DC, Zhu J, Devoe CE, A phase 1b study of gemcitibine plus PDGPH2 (pegylated recombinant human hyaluronidase) in patients with stage IV previously untreated pancreatic cancer, 2013, J Clin Oncol 31, abstr 4010.
  17. Shaw AT, Mehra R, Kim DW, Felip E, Chow LQM, Camidge DR, Tan DSW, Vansteenkiste JF, Sharam S, De Pas T, Wolf J, Katayama R, Lau YYY, Goldwasser M, Boral A, Engelman JA, Clinical activity of the ALK inhibitor LDK378 in advanced ALK-positive NSCLC, 2013, J Clin Oncol 31, abstr 8010.
  18. Thompson JA, Forrero A, Heath EI, Pal SK, Ansell SM, Infante JR, De Vos S, Hamlin PA, Whiting NC, Zhao B, Tannir NM, SGN-75 in the treatment of patients with CD70-positive malignancies including metastatic renal cell carcinoma, 2013, J Clin Oncol 31, abstr 368.
  19. Laura Quan Man Chow, Michael S. Gordon, Theodore F. Logan, Scott J. Antonia, Shailender Bhatia, John A. Thompson, Julie R. Brahmer, Gretchen Solberg, Rachel Bittner, David Fontana, Joseph Grosso, Lewis J. Cohen, Christoph Matthias Ahlers, Jon M. Wigginton, Charles G. Drake. Phase I dose escalation study of recombinant interleukin-21 (rIL-21; BMS-982470) in combination with nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients (pts) with advanced or metastatic solid tumors.2013, Journal of Clinical Oncology 31, no. 15_supp.
  20. Shailender Bhatia, Brendan D. Curti, Michael S. Gordon, Jason Chesney, Theodore Logan, John A. Thompson, Nels Royer, Rachel Bittner, David Fontana, Joseph Grosso, Pamela L. Clemens, Lewis J. Cohen, Christoph Matthias Ahlers, Jon M. Wigginton, Patrick Hwu. Phase I dose escalation study of recombinant interleukin-21 (rIL-21, BMS-982470) in combination with ipilimumab (Ipi) in patients (pts) with advanced or metastatic melanoma (MM). 2013 Journal of Clinical Oncology 31, no. 15_suppl.DOI: 10.1200/jco.2013.31.15_suppl.tps3109.
  21. Segal NH, Gopal AK, Bhatia S, Kohrt HE, Levy R, Pishvaian MJ, Houot R, Bartlett N, Nghiem P, Kronenberg SA, Thall AD, Mugundu G, Huang B, Davis C, A phase 1 study of PF-05082566 (anti-4-1BB) in patients with advanced cancer, 2014, J Clin Oncol 32:5s, abstr 3007.
  22. Seiwert TY, Burtness B, Weiss J, Gluck I, Eder JP, Pai SI, Dolled-Filhart M, Emancipator K, Pathiraja K, Gause C, Iannone R, Brown H, Houp J, Cheng JD, Chow LQM, A phase 1b study of MK-3475 in patients with human papillovirus (HPV)-associated and non-HPV-associated head and neck (H/N) cancer, 2014, J Clin Oncol 32:5s, abstr 6011.
  23. Forero-Torres A, Modi S, Specht J, Miller K, Weise A, Burris III H, Liu M, Krop I, Pusztai L, Kostic A, Li M and Mita M. SGN-LIV1: A Phase 1 study evaluating a novel antibody-drug conjugate in patients with LIV-1 positive breast cancer. 2014 San Antonio Breast Cancer Symposium.Publication Number: OT2-3-01.
  24. Chihiro Morishima, Douglas G McNeel, Manish R Patel, Holbrook Kohrt, Thomas A Waldmann, John A Thompson, Kevin Conlon, Paul M Sondel, Heather Wakelee, Mary L Disis, Stephen P Creekmore and Jeffrey S Miller.CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhil-15) is associated with robust expansion of peripheral blood CD56+ NK cells.Journal for ImmunoTherapy of Cancer20142(Suppl 3):P80.
  25. E. Felip; D. Kim; R. Mehra; D.S.W. Tan; L.Q. Chow; D.R. Camidge; J.F. Vansteenkiste; S. Sharma; T. De Pas; G.J. Riely; B. Solomon; J. Wolf; M. Thomas; M. Schuler; G. Lui; A. Santoro; M. Geraldes; A.L. Boral; A. Yovine; A.T. Shaw. EFFICACY AND SAFETY OF CERITINIB IN PATIENTS (PTS) WITH ADVANCED ANAPLASTIC LYMPHOMA KINASE (ALK)-REARRANGED (ALK+) NON-SMALL CELL LUNG CANCER (NSCLC): AN UPDATE OF ASCEND-19. Ann Oncol (2014) 25 (suppl_4): iv456-iv457.
  26. A.T. Shaw; R. Mehra; D.S.W. Tan; E. Felip; L.Q. Chow; D.R. Camidge; J.F. Vansteenkiste; S. Sharma; T. De Pas; G.J. Riely; B. Solomon; J. Wolf; M. Thomas; M. Schuler; G. Liu; A. Santoro; M. Geraldes; A.L. Boral; A. Yovine; D. Kim .EVALUATION OF CERITINIB-TREATED PATIENTS (PTS) WITH ANAPLASTIC LYMPHOMA KINASE REARRANGED (ALK+) NON-SMALL CELL LUNG CANCER (NSCLC) AND BRAIN METASTASES IN THE ASCEND-1 STUDY.Ann Oncol (2014) 25 (suppl_4): iv455-iv456.
  27. Tan DS, Shaw AT, Mehra R, Felip E, Chow LQM, D. Camidge R, Vansteenkiste JF, Sharma S, De Pas T, Riely GJ, Solomon BJ, Wolf J, Thomas M, Schuler MH, Liu G, Santoro A, Geraldes M, Boral A, Yovine AJ, Kim DW. Ceritinib in Asian versus Caucasian patients (Pts) with advanced anaplastic lymphoma kinase (ALK)-rearranged (ALK+) NSCLC: Subgroup analysis of the ASCEND-1 trial. Journal of Clinical Oncology 32, no. 15_suppl (May 2014) 8078-8078.
  28. L.Q. Chow; B. Burtness; J. Weiss; R. Berger; J.P. Eder; E.J. Gonzalez; J. Pulini; J. Johnson; M. Dolled-Filhart; K. Emancipator; J.K. Lunceford; K. Pathiraja; C. Gause; J.D. Cheng; T. Seiwert. A PHASE IB STUDY OF PEMBROLIZUMAB (PEMBRO; MK-3475) IN PATIENTS (PTS) WITH HUMAN PAPIILLOMA VIRUS (HPV)-POSITIVE AND NEGATIVE HEAD AND NECK CANCER (HNC).Ann Oncol (2014) 25 (suppl_4): mdu438.32.
  29. K. Muro; Y. Bang; V. Shankaran; R. Geva; D.V.T. Catenacci; S. Gupta; J.P. Eder; R. Berger; E.J. Gonzalez; J. Pulini; A.B. Ray; M. Dolled-Filhart; K. Emancipator; K. Pathiraja; X. Shu; M.R. Koshiji; J. Cheng; H.C. Chung. A PHASE 1B STUDY OF PEMBROLIZUMAB (PEMBRO; MK-3475) IN PATIENTS (PTS) WITH ADVANCED GASTRIC CANCER. Ann Oncol (2014) 25 (suppl_4): mdu438.15.
  30. Mufti, GJ; Estey, E; Popat, R; Mattison, R; Menne, T; Azar, J; Bloor, A., Gaymes, TJ, Khwaj, A., Juckett, M., Lennard A., Zhang C., Gallant, G. J. A., Gopal, A.K. RESULTS OF A PHASE 1 STUDY OF BMN 673, A POTENT AND SPECIFIC PARP-1/2 INHIBITOR, IN PATIENTS WITH ADVANCED HEMATOLOGICAL MALIGNANCIES.2014  proceedings of 19th Congress of the European-Hematology-Association. (pp. 33-34).
  31. Stein MN, Chow LQM, Smith DC, Shepard DR, Wang D, Powderly JD, Gao L, Lin Y, Koshiji M. Phase II study evaluating the effect of concomitant ramucirumab (IMC-1121B; RAM) on the pharmacokinetics (PK) of docetaxel (DOC) in patients (pts) with advanced malignant solid tumors. J Clin Oncol 32, 2014 (suppl; abstr e13539).
  32. Chow LQM, Smith DC, Tan AR, Denlinger CS, Wang D, Shepard DR, Chaudhary A, Lin Y, Koshiji M. Phase II study evaluating the effect of concomitant ramucirumab (IMC-1121B; RAM) on the pharmacokinetics (PK) of paclitaxel (PTX) and the PK of RAM as monotherapy in patients (pts) with advanced malignant solid tumors. J Clin Oncol 32, 2014 (suppl; abstr e13554).
  33. Thompson JA, Motzer R, Molina AM, Choueiri TK, Heath EI, Kollmannsberger CK, Redman BG, Sangha RS, Ernst DS, Pili R, Butturini A, Wiseman A, Trave F, Anand B, Huang Y, Reyno LM, Phase 1 studies of anti-ENPP3 antibody drug conjugates (ADCs) in advanced refractory renal cell carcinomas (RRCC), 2015, J Clin Oncol 33, abstr 2503.
  34. Atkins MB, Choueiri TK, Hodi FS, Thompson JA, Hwu WJ, McDermott DF, Brookes M, Tosolini A, Ebbinghaus S, Yang Z, Gause CK, Perini RF, Ribas A, Pembrolizumab (MK-3475) plus low-dose ipilimumab (IPI) in patients (pts) with advanced melanoma (MEL) or renal cell carcinoma (RCC): Data from the KEYNOTE-029 phase 1 study, J Clin Oncol 33, 2015, abstr 3009.
  35. Chawla SP, Schoffski P, Blay JY, Jones RL, Gelderblom H, Attia S, Chmielowski B, Van Tine BA, Trent JC, Patel S, Wagner AJ, Viele JK, Chugh R, Le Cesne A, Tinoco G, Sankhala KK, Falcone J, Schweizer C, Weil S, Maki RG, A Study of the Safety and Efficacy of the Combination of Gemcitabine and Docetaxel with ontuxizumab (MORAb-004) in Metastatic Soft Tissue Sarcoma, 2015, J Clin Oncol 33, abstr TPS10577.
  36. Gopal AK, Bartlett NL, Levy R, Houot R, Smith SD, Segal NH, Thall AD, Mugundu G, Huang B, Davis C, Kohrt HE, A phase 1 study of PF-05082566 (anti-4-1BB) + rituximab in patients with CD20+ NHL, 2015, J Clin Oncol 33, abstr 3004.
  37. Hingorani SR, Harris WP, Hendifar AE, Bullock AJ, Wu XW, Huang Y, Jiang P, High response rate and PFS with PEGPH230 added to nab-paclitaxel/gemcitabine in stage IV previously untreated pancreatic cancer patients with high-HA tumors: Interim results of a randomized phase II study, 2015, J Clin Oncol 33, abstr 4006.
  38. Hamid O, Chow LQM, Tavokkoli F, Marshall S, Gribbin MJ, Karakunnel JJ, Gray JE, Phase 1, open-label study of MEDI0680, an anti-programmed cell death-1 (PD-1) antibody, in combination with MEDI4736, an anti-programmed cell death ligand-1 (PD-L1) antibody, in patients with advanced malignancies, 2015, J Clin Oncol 33, abstr TPS3087.
  39. Somaiah N, Block MS, Kim JW, Shapiro G, Hwu P, Eder JP, Jones RL, Gnjatic S, Lu H, Hsu FJ, Pollack S, Phase 1, first-in-human trial of LV305 in patients with advanced or metastatic cancer expressing NY-ESO-1, 2015, J Clin Oncol 33, abstr 3021.
  40. Forero A, Burris III H, Mita M, Specht J, Weise A, Liu MC C, Modi S, Pusztai L, Kostic A, Yang J, Li M, Hengel S and Miller K.Interim analysis of a phase 1 study of the antibody-drug conjugate SGN-LIV1A in patients with metastatic breast cancer.2015 San Antonio Breast Cancer Symposium.Publication Number: P3-14-05.
  41. Chihiro Morishima, Douglas G McNeel, Manish R Patel, Holbrook E Kohrt, Thomas A Waldmann, John A Thompson, Kevin C Conlon, Paul M Sondel, Heather A Wakelee, Minjun C Apodaca, Steven P Fling, Mary L Disis, Stephen P Creekmore and Jeffrey S Miller. CITN11-02 interim trial results: subcutaneous administration of recombinant human IL-15 (rhIL-15) is associated with expansion of peripheral blood CD56+ NK cells and CD8+ T cells.Journal for ImmunoTherapy of Cancer20153(Suppl 2):P203.
  42. L. Buisseret; J. Specht; E.C. Dees; R. Berger; S. Gupta; R. Geva; L. Pusztai; C.K. Gause; V. Karantza; R. Nanda. KEYNOTE-012: A phase Ib study of pembrolizumab (MK-3475) in patients (pts) with metastatic triple-negative breast cancer (mTNBC).Ann Oncol (2015) 26 (suppl_3): iii6.
  43. A. Hendifar; S. Hingorani; W. Harris; T. Seery; D. Sigal; W. Wu; S. Dychter; P. Jiang. High Response Rate and PFS with PEGPH20 added to Nab-Paclitaxel/Gemcitabine in Stage IV Previously Untreated Pancreatic Cancer Patients with High-HA Tumors: Interim Results of a Randomized Phase 2 Study. Ann Oncol (2015) 26. (suppl_4): iv117.
  44. Y-J. Bang; H.C. Chung; V. Shankaran; R. Geva; D. Catenacci; S. Gupta; J.P. Eder; R. Berger; K. Emancipator; K. Pathiraja; T. McClanahan; M. Ayers; J. Lunceford; J. Cheng; M. Koshiji; K. Muro.Clinical outcomes and their correlation with gene expression in patients with advanced gastric cancer treated with pembrolizumab (MK-3475): KEYNOTE-012.Ann Oncol (2015) 26 (suppl_4): iv118.
  45. Rita Nanda, Laura Q Chow, E Claire Dees, Raanan Berger, Shilpa Gupta, Ravit Geva, Lajos Pusztai, Marisa Dolled-Filhart, Kenneth Emancipator, Edward J Gonzalez, Jennifer Houp, Kumudu Pathiraja, Vassiliki Karantza, Robert Iannone, Christine K Gause, Johnathan D Cheng, and Laurence Buisseret. A phase Ib study of pembrolizumab (MK-3475) in patients with advanced triple-negative breast cancer.Cancer Res 2015;75(9 Suppl):Abstract nr S1-09.
  46. R.L. Jones, J.C. Bendell, D.C. Smith, K. Deifenbach, J. Lettieri, O. Boix, A.C. Lockhart, C.L. O'Bryant, K.N. Moore. A Phase I open-label trial evaluating the cardiovascular safety of regorafenib in patients with advanced cancer. European journal of cancer. Volume 51, Supplement 3, Pages S336–S337.
  47. Chow LQM, Mehra R, Haddad R, Gupta S, Weiss J, Berger R, Burtness B, Thara M, Keam B, Le D, Cheng J, Health K, Pathiraja K, Seiwert T. Antitumor activity of the Anti-PD-1 antibody pembrolizumab in subgroups of patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC): Exploratory analyses from KEYNOTE-012. Poster Presentation at the European Cancer Congress, Vienna, Austria. September 2015.
  48. Peter H. O'Donnell, Elizabeth R. Plimack, Joaquim Bellmunt, Raanan Berger, Robert B. Montgomery, Karl Heath, Marisa Dolled-Filhart, Kumudu Pathiraja, Christine K. Gause, Jonathan D. Cheng, Rodolfo F. Perini, Shilpa Gupta. Pembrolizumab (Pembro; MK-3475) for advanced urothelial cancer: Results of a phase IB study.J Clin Oncol 33, 2015 (suppl 7; abstr 296).
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  50. Bendell JC, Kim TW, Goh BC, Wallin J, Oh DY, Han SW, Lee CB, Hellmann MD, Desai J, Lewin JH, Solomon BJ, Chow LQM, Miller WH, Gainor JF, Flaherty K, Infante JR, Das-Thakur M, Foster P, Cha E, Bang YJ, Clinical activity and safety of cobimetinib (cobi) and atezolizumab in colorectal cancer (CRC), 2016, J Clin Oncol 34, abstr 3502.
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