Annemarie F. Shepherd, MD

Dr. Annemarie Shepherd is a radiation oncologist, a clinical researcher and the medical director of Fred Hutch Cancer Center - Proton Therapy. 

After graduating from Rutgers University Robert Wood Johnson Medical School, Dr. Shepherd completed a residency in radiation oncology at the University of Pennsylvania Perelman School of Medicine. 

Dr. Shepherd’s research focuses on advancing radiation therapy techniques for patients with thoracic tumors. Her current efforts are concentrated on proton therapy, lung cancer, thymic tumors and understanding radiation-related toxicity and patients with inherent sensitivity to radiation. She has published extensively and written, run and led multiple clinical trials.

Dr. Shepherd has particular interest in thymic tumors, serving on the board of the International Thymic Malignancy Interest Group and as chair and moderator of the ITMIG Tumor Boards. She has been involved in multiple clinical thymic projects and was the principal investigator of an investigator-initiated trial looking at treating the whole pleura with intensity-modulated pleural radiation therapy (IMPRINT) using proton therapy in thymic patients with pleural metastases.

She is involved in studying the benefits of proton therapy in thoracic tumors, including understanding which patients benefit the most from this targeted technology. Patient populations of interest to Dr. Shepherd include patients who require reirradiation, those who have large radiation fields/targets, people at high risk of radiation complications and those who require post-operative radiation therapy.

Dr. Shepherd is board-certified in radiation oncology by the American Board of Radiology.