Joshua T. Schiffer, M.D., M.Sc.

faculty member

Joshua T. Schiffer, M.D., M.Sc.

Associate Member
Vaccine and Infectious Disease Division, Fred Hutch

Associate Member
Clinical Research Division, Fred Hutch

Fax: 206.667.6366
Mail Stop: E4-100

Dr. Joshua Schiffer is an infectious disease physician and researcher who develops mathematical models to address significant medical challenges. A major focus of his work is to analyze strategies to achieve an HIV cure in people who require antiviral drugs for their entire lifetime, due to reservoirs of latent virus. These models assess the potential of a wide variety of potential curative technologies. Such strategies include stopping the proliferation of latently infected cells, damaging the DNA of HIV that is woven into the genes of infected T cells, using genetic engineering to create T cells that resist HIV infection, or infusing doses of tiny immune proteins to block infection of new cells. Dr. Schiffer and colleagues also use mathematical modeling to study how T cells help control numerous herpes viruses that cause disease in healthy people and in cancer patients with compromised immune systems. They develop models to explain when and how latent viruses reactivate and use models to optimize the effectiveness of antiviral drugs.

Other Appointments & Affiliations

Associate Professor, Department of Medicine
University of Washington

Attending Physician, SCCA Infectious Consulting Service
Seattle Cancer Care Alliance

Education

M.D., Johns Hopkins University School of Medicine, 2002

M.S., Epidemiology, University of Washington, 2009

Research Interests

Describing the quantitative and dynamical features of human pathogens and immune responses

Pathogenesis of HSV-2 infection

Applying models to optimize viral eradication strategies, and to use models to capture kinetic features of the human microbiome

Current Projects

HIV Cure

Herpes Simplex Virus-2 Dynamics

Tissue Resident T Cells

Viral Dynamics in Infants

Microbiome Dynamics

Viral Infections in Cancer Patients

Dr. Schiffer in the News

Guiding inactivity of latent HIV reservoirs

Science Spotlight - September 17, 2018

Models aren’t just pretty

Science Spotlight - September 17, 2018

A voice for HIV cure

Hutch News - November 29, 2017

For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email media@fredhutch.org or call 206.667.2210.