Vaccine and Infectious Disease Division, Fred Hutch
Clinical Research Division, Fred Hutch
Dr. Joshua Schiffer is an infectious disease physician and researcher who develops mathematical models to address significant medical challenges. A major focus of his work is to analyze strategies to achieve an HIV cure in people who require antiviral drugs for their entire lifetime, due to reservoirs of latent virus. These models assess the potential of a wide variety of potential curative technologies. Such strategies include stopping the proliferation of latently infected cells, damaging the DNA of HIV that is woven into the genes of infected T cells, using genetic engineering to create T cells that resist HIV infection, or infusing doses of tiny immune proteins to block infection of new cells. Dr. Schiffer and colleagues also use mathematical modeling to study how T cells help control numerous herpes viruses that cause disease in healthy people and in cancer patients with compromised immune systems. They develop models to explain when and how latent viruses reactivate and use models to optimize the effectiveness of antiviral drugs.
Associate Professor, Department of Medicine
University of Washington
Attending Physician, SCCA Infectious Consulting Service
Seattle Cancer Care Alliance
M.S., Epidemiology, University of Washington, 2009
M.D., Johns Hopkins University School of Medicine, 2002
Describing the quantitative and dynamical features of human pathogens and immune responses
Pathogenesis of HSV-2 infection
Applying models to optimize viral eradication strategies, and to use models to capture kinetic features of the human microbiome
Herpes Simplex Virus-2 Dynamics
Tissue Resident T Cells
Viral Dynamics in Infants
Viral Infections in Cancer Patients
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