Assistant Member, Pediatric Oncology and Stem Cell and Gene Therapy Programs, Integrated Immunotherapy Research Center
Clinical Research Division, Fred Hutch
Dr. Brandon Hadland is a hematologist/oncologist and stem cell transplantation expert who treats young patients in Seattle Children’s Hospital transplant service. His research focuses on the origin of hematopoietic stem cells, which give rise to blood and immune cells. He harnesses new technologies to simultaneously analyze gene activities across the many different cell types within the physical site where the stem cells evolve and to characterize interactions between those various cells. He aims to identify the specific biological signals that trigger the formation of blood stem cells. His ultimate goal is to generate new sources of blood stem cells that could one day be used to correct inherited, blood-based diseases.
University of Washington School of Medicine, Department of Pediatrics, Division of Hematology/Oncology
Seattle Children’s Hospital, Pediatric Hematology/Oncology and Bone Marrow Transplant
Harvey Mudd College, Claremont, CA; B.S., Chemistry, 1998
Washington University School of Medicine, Saint Louis, MO; M.D., Ph.D. in Molecular Cell Biology, 2006
Seattle Children’s Hospital/University of Washington School of Medicine, Department of Pediatrics, Seattle, WA; Pediatrics Internship, 2006-2007; Pediatrics Residency, 2007-2009
Seattle Children’s Hospital/University of Washington School of Medicine/Fred Hutchinson Cancer Research Center, Department of Pediatrics, Division of Hematology/Oncology, Seattle, WA; Pediatric Hematology/Oncology Fellowship, 2009-2012
Fred Hutchinson Cancer Research Center, Clinical Research Division, Seattle, WA; Research Associate, 2012-2018
U. of Washington School of Medicine, Department of Pediatrics, Division of Hematology/Oncology; Acting Instructor, 2012-2016
U. of Washington School of Medicine, Department of Pediatrics, Division of Hematology/Oncology; Acting Assistant Professor, 2016-2018
Role of Notch and other signal pathways in embryonic hematopoietic stem cell development,
Analysis of the hematopoietic niche during hematopoietic stem cell emergence, using single cell functional and molecular techniques,
Laboratory platforms for engineering hematopoietic stem and progenitor cell development,
Directed differentiation of murine and human pluripotent stem cells (that can make many different cell types) to selectively hematopoietic stem and progenitor cells, and
Development of certain (“innate-like”) immune cells during embryonic hematopoiesis
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