Executive Vice President and Deputy Director
Clinical Research Division, Fred Hutch
Human Biology Division, Fred Hutch
Rosput Reynolds Endowed Chair
Dr. Bruce Clurman is the executive vice president and deputy director of Fred Hutch. He studies the cell cycle, the molecular pathways that drive cells to multiply. This work includes understanding how protein destruction by the ubiquitin–proteasome system controls the cell cycle in normal and cancer cells. His ultimate goal is to understand how these fundamental regulatory pathways shape cancer development and progression, and use this understanding to design new cancer therapies that target these pathways. For example, his group is developing a treatment strategy to capitalize on mutations in key growth-accelerating genes called CDKs. This strategy would push cancer cells toward an unsustainable level of DNA damage without killing healthy cells. Dr. Clurman’s team also is studying how mutations in the gene for Fbw7, a component of the system that regulates destruction of a network of tumor-driving proteins, can cause cancer. The team is designing a drug to restore the function of the mutant Fbw7 in cancers and thus rein in tumor growth.
Department of Medicine, University of Washington
Department of Pathology, University of Washington
1981 – B.A., University of Virginia, Charlottesville, VA (Philosophy)
1988 – Ph.D., Cornell University Graduate School of Medical Sciences, New York, NY (Viral Oncology)
1989 – M.D., Cornell University Medical College, New York, NY (Medicine)
Residency: Brigham and Women’s Hospital, Boston, MA
Fellowship: Medical Oncology/Molecular Medicine, Fred Hutch and University of Washington
Identifying new CDK targets
Development of novel drug therapy targeting mutant ubiquitin ligases in cancer
Therapeutic targeting of replication stress failure in cancer cells with aberrant CDK2 activity
New mouse models of Fbw7- and cell cycle–associated cancer
Bioinformatic and high-throughput approaches to identify therapeutic targets in cell cycle– and Fbw7-associated cancers
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