Bruce Clurman, M.D., Ph.D.

FACULTY MEMBER

Bruce Clurman, M.D., Ph.D.

Executive Vice President and Deputy Director
Fred Hutch

Member
Clinical Research Division, Fred Hutch

Member
Human Biology Division, Fred Hutch

Rosput Reynolds Endowed Chair
Fred Hutch

Fax: 206.667.5255
Mail Stop: D2-100

Dr. Bruce Clurman is the executive vice president and deputy director of Fred Hutch. He studies the cell cycle, the molecular pathways that drive cells to multiply. This work includes understanding how protein destruction by the ubiquitin–proteasome system controls the cell cycle in normal and cancer cells. His ultimate goal is to understand how these fundamental regulatory pathways shape cancer development and progression, and use this understanding to design new cancer therapies that target these pathways. For example, his group is developing a treatment strategy to capitalize on mutations in key growth-accelerating genes called CDKs. This strategy would push cancer cells toward an unsustainable level of DNA damage without killing healthy cells. Dr. Clurman’s team also is studying how mutations in the gene for Fbw7, a component of the system that regulates destruction of a network of tumor-driving proteins, can cause cancer. The team is designing a drug to restore the function of the mutant Fbw7 in cancers and thus rein in tumor growth.

Other Appointments & Affiliations

Professor
Department of Medicine, University of Washington

Adjunct Professor
Department of Pathology, University of Washington

Education

1981 – B.A., University of Virginia, Charlottesville, VA (Philosophy)

1988 – Ph.D., Cornell University Graduate School of Medical Sciences, New York, NY (Viral Oncology)

1989 – M.D., Cornell University Medical College, New York, NY (Medicine)

Residency: Brigham and Women’s Hospital, Boston, MA

Fellowship: Medical Oncology/Molecular Medicine, Fred Hutch and University of Washington

Current Projects

Identifying new CDK targets

Development of novel drug therapy targeting mutant ubiquitin ligases in cancer

Therapeutic targeting of replication stress failure in cancer cells with aberrant CDK2 activity

New mouse models of Fbw7- and cell cycle–associated cancer

Bioinformatic and high-throughput approaches to identify therapeutic targets in cell cycle– and Fbw7-associated cancers

SPOTLIGHT

“We’re doing the opposite of what you’d expect. We want to take advantage of existing mutations to push tumor cells toward levels of DNA damage they can’t survive.”

— Dr. Bruce Clurman

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For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email media@fredhutch.org or call 206.667.2210.