Guang-Shing Cheng, M.D.

Dr. Guang-Shing Cheng M.D.

Guang-Shing Cheng, M.D.

Associate Professor
Clinical Research Division, Fred Hutch

Mail Stop: D5-360

Dr. Guang-Shing Cheng is a pulmonologist who focuses on improving outcomes for cancer patients who have respiratory failure and lung complications related to their cancer treatments. She is developing new ways to prevent lung damage and improve lung function in these patients. Dr. Cheng’s main interest is bronchiolitis obliterans syndrome, a serious complication of blood stem cell transplantation. She also studies the role of respiratory viruses and other infectious pathogens in lung disease in patients with compromised immune systems.

Other Appointments & Affiliations

Associate Professor, Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine
University of Washington

Attending Physician, Pulmonary / Critical Care Medicine
Fred Hutchinson Cancer Center


B.A. (Biology): Harvard University; Cambridge, MA; 1996

M.D. (Medicine): University of California at San Francisco; San Francisco, CA; 2001

Internship/Residency (Internal Medicine): Yale-New Haven Hospital; New Haven, CT; 2005

Pulmonary/Critical Care Fellowship: Yale University School of Medicine; New Haven, CT; 2008

Postdoctoral Fellowship: University of Pennsylvania School of Medicine; Philadelphia, PA; 2009

Clinical Expertise

Dr. Cheng is a pulmonologist and critical care specialist who sees patients at the Fred Hutch with respiratory problems including complications of their cancer treatment. She also has expertise in diagnosing lung nodules due to a variety of causes, including lung cancer. She attends in the Pulmonary Consult Service and the Lung Cancer Early Detection and Prevention Clinic at Fred Hutch. Dr. Cheng performs bronchoscopies for the diagnosis of respiratory infections and lung cancer. She also attends in the Intensive Care Unit at the University of Washington.

She has authored multiple manuscripts in peer-reviewed journals about BOS and other lung complications after HCT. She edited an issue of Clinics in Chest Medicine on pulmonary disease in non-pulmonary malignancies. In addition, she has authored two chapters in Murray and Nadel, a definitive test on pulmonary disorders.

Current Projects

Dr. Cheng’s goal is to improve outcomes for stem cell transplant patients with infectious and non-infectious lung disease. Her research focuses on bronchiolitis obliterans syndrome (BOS), which is a complication of chronic graft-versus-host disease in patients who have received HCT. Currently, there are no therapies that routinely reverse the course of the disease. Dr. Cheng is working to develop early detection and prevention strategies for HCT patients, including the use of wireless handheld spirometry monitoring, which may lead to earlier treatment. She is also involved in multicenter trials testing new drugs for the treatment of BOS and other lung diseases after HCT. She is investigating the relationship between respiratory viral infection and the development of lung disease in these patients.

Find a Clinical Trial Led by Dr. Cheng

Dr. Cheng in the News

How COVID-19 has opened science

Hutch News - September 15, 2020

Earlier detection for a deadly lung disease

Hutch News - March 25, 2019

Pulmonologist Cheng joins Center

Hutch News - April 30, 2012

For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email or call 206.667.2210