Dr. E. Donnall Thomas and his colleagues discovered a way to treat advanced leukemia by eradicating malignant white blood cells in the bone marrow using high doses of chemotherapy and radiation, and then replacing them with healthy donor cells. This revolutionary approach was the first definitive and reproducible example of the human immune system’s potential to eliminate cancer, and it earned Thomas a Nobel Prize in 1990. Today, cell-based therapies have become a standard of care for many patients with cancer and other diseases.
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