Fred Hutch Cancer Center’s latest findings on cancer biology, early-onset colorectal cancer, breast cancer treatments and more will be featured at the annual meeting of the American Association for Cancer Research (AACR).
Date:
Friday-Wednesday, April 17-22, 2026
Host or Sponsor:
Location:
San Diego, California
Contact Information:
Advances in Population Sciences
Presentation: ZNA and Cancer: How Characteristics of Patient Zip Codes and Neighborhoods Drive Cancer Burden
Presenter: Trang VoPham
Date & Time: April 19, 2026, 1:00–2:30 p.m.
Advances in Prevention Research
Presentation: Precision Screening: Opportunities to Enhance the Benefits of Cancer Screening
Presenter: Chris Li
Date & Time: April 19, 2026, 1:00–2:30 p.m.
Microbiome, Inflammation, and Response to Immunotherapy in Cancer
Presentation: Constitutive NRF2 activation drives excess cysteine stress
Presenter: Jennifer Brain
Date & Time: April 19, 2026, 2:00–5:00 p.m.
Mechanisms of Drug Resistance 1
Presentation: Cysteine-driven drug inactivation undermines covalent drug efficacy and drives resistance
Presenter: Maximilian Kobiesa
Date & Time: April 19, 2026, 2:00–5:00 p.m.
Environmental and Occupational Risk Factors, Infection, and Aging
Presentation: Molecular Standard of Care
Presenter: Sam Phillips
Date & Time: April 19, 2026, 2:00–5:00 p.m.
Genomic Dissection to Define Novel Therapeutic Strategies
Presentation: REST represses neuroendocrine transcriptional programs and enables anti-tumor immunity in SCLC
Presenter: Jackson Fatherree
Date & Time: April 19, 2026, 2:00–5:00 p.m.
Late-Breaking Research: Clinical Research 1
Presentation: Prostate cancer phenotypes determined from circulating tumor DNA associate with outcomes to 177Lu-PSMA-617 therapy
Presenter: Arthur McDeed
Date & Time: April 19, 2026, 2:00–5:00 p.m.
Immunology, Tumor Microenvironment
Presentation: The Necrotic Tumor Microenvironment as an Instigator of Metastatic Aggression and Immuno‑evasion
Presenter: Kevin Cheung
Date & Time: April 19, 2026, 1:00–2:30 p.m.
Population Sciences at the Forefront 2: Molecular and Genetic Epidemiology of Cancer Risk and Outcomes
Presentation: Assessing paralog dependency in ovarian cancer to drive target discovery
Presenter: Amy Lowe
Date & Time: April 19, 2026, 2:00–5:00 p.m.
Microenvironmental Determinants of Tumor Evolution and Immune Escape
Presentation: Competition for dendritic cells limits engineered TCR-T cell activation in tumor-draining lymph nodes and impairs synergy with PD-L1 blockade
Presenter: William Samuel Nutt
Date & Time: April 19, 2026, 3:00–5:00 p.m.
Cancer Disparities
Presentation: Outcomes after introduction of cervical cancer screening in an opioid treatment program (OTP) by offering HPV self-collect testing to an under-screened population
Presenter: Elizabeth Swisher
Date & Time: April 20, 2026, 9:00 a.m.–12:00 noon
Community-Engaged Approaches to Equity Across the Cancer Journey: From Prevention to Trial Design
Presentation: Science and Storytelling: Using a multi-component evidenced based strategy for successful recruitment of Black women with high-risk endometrial cancer to The SISTER Study
Presenter: Kemi Doll
Date & Time: April 20, 2026, 9:00 a.m.–12:00 noon
Metabolic Regulation in Breast and Gynecologic Cancers
Presentation: Engineering multiplexed NRF2 reporters to decipher single cell oscillations in real time
Presenter: Naurisha Kapoor
Date & Time: April 20, 2026, 9:00 a.m.–12:00 noon
Data-Driven Approaches to Precision Oncology
Presentation: Prospective organoid drug profiling and clinical response correlation for patients with primary or recurrent ovarian carcinoma (OC) in the PROSPERITY study
Presenter: Elizabeth Swisher
Date & Time: April 20, 2026, 9:00 a.m.–12:00 noon
Oncogenic Transcription Factors and Cancer Programs
Presentation: Multi-omic single-cell assessment of castration-resistant prostate cancer patients receiving 177Lu-PSMA-617 and pembrolizumab shows timing of radioligand therapy alters immune response
Presenter: Anusha Muralidhar
Date & Time: April 20, 2026, 9:00 a.m.–12:00 noon
Tumor-induced Immune Suppression
Presentation: Non-canonical CAR T cell states correlate with durable therapeutic responses in multiple myeloma patients
Presenter: Kai Wu
Date & Time: April 20, 2026, 2:30–4:30 p.m.
Genetic and Transcriptomic Dissection of Cancer Evolution
Presentation: Interaction between T-cell inflamed gene expression profile score and tumor-associated microbiome on colorectal cancer mortality in a heterogeneous patient population
Presenter: Meredith Hullar
Date & Time: April 20, 2026, 2:00–5:00 p.m.
Mechanisms of Drug Resistance 2
Presentation: Systematic assessment of histomorphologic and immunohistochemical features in metastatic castration-resistant prostate cancer biopsies
Presenter: Elnaz Mahmoudabadi
Date & Time: April 20, 2026, 2:00–5:00 p.m.
Metabolite Control of Chromatin, Redox, and Cellular Stress Responses
Presentation: MAPK driven kinetochore instability as a biomarker and therapeutic vulnerability in glioblastoma
Presenter: Patrick Paddison
Date & Time: April 20, 2026, 2:00–5:00 p.m.
First-in-Human Phase I Clinical Trials
Presentation: A phase 1B investigator-initiated trial of niraparib lead-in, followed by niraparib plus dostarlimab for metastatic BRCA1/2-mutated breast, tubo-ovarian, and pancreatic cancers
Presenter: Elizabeth Swisher
Date & Time: April 20, 2026, 9:00 a.m.–12:00 noon
Late-Breaking Research: Tumor Biology 1
Presentation: Single-cell and spatially resolved transcriptomics identifies clinically targetable myeloid niches in fibrolamellar carcinoma
Presenter: Jason Carter
Date & Time: April 20, 2026, 2:00–5:00 p.m.
Innovative Targeted and Cellular Therapies for Exploiting Cancer Vulnerabilities
Presentation: Cysteine accumulation as a driver of resistance to bortezomib
Presenter: Jennifer Brain
Date & Time: April 20, 2026, 9:00 a.m.–12:00 noon
Spatial Biomarkers at Single-Cell Resolution: Mapping Tumor Ecosystems with Proteomics, Transcriptomics, and AI
Presentation: Dissecting myeloid-driven mechanisms of immunotherapy resistance in prostate cancer bone metastases
Presenter: Aram Lyu
Date & Time: April 20, 2026, 2:30–4:30 p.m.
TCR and Autologous T Cell Therapies
Presentation: Induction of epidermal-like differentiation irreversibly limits the invasive and metastatic potential of basal-like breast cancer cells
Presenter: Justin Hui
Date & Time: April 21, 2026, 9:00 a.m.–12:00 noon
Diagnostic Biomarkers 1
Presentation: Utility of long-read RNA-sequencing for isoform and fusion discovery in lung cancer
Presenter: Alice Berger
Date & Time: April 21, 2026, 2:00–5:00 p.m.
Clinical Correlates of Immunotherapy
Presentation: Agricultural glyphosate use and early-onset colorectal cancer mortality in the United States
Presenter: Jiayu Lin
Date & Time: April 21, 2026, 2:00–5:00 p.m.
Immunomodulatory Effects of Targeted Therapies
Presentation: Cytotoxic T-cell signatures underlie therapeutic response to 177Lu-DOTATATE plus pembrolizumab in well-differentiated gastroenteric neuroendocrine tumors
Presenter: Naoki Mizutani
Date & Time: April 21, 2026, 2:00–5:00 p.m.
Genetic and Transcriptomic Dissection of Cancer Evolution
Presentation: Characterization of cancer-reactive T cells and neoantigen-specific T cell receptors
Presenter: Wei Sun
Date & Time: April 21, 2026, 2:00–5:00 p.m.
Molecular Targets 1
Presentation: Spatial transcriptomics profiling of colorectal cancer tumors in Alaska Native peoples: Discovery of prognostic biomarkers
Presenter: Garrick Chang
Date & Time: April 21, 2026, 2:30–4:30 p.m.
Genomic Dissection to Define Novel Therapeutic Strategies
Presentation: Biologic processes enriched in the primary tumors of invasive breast cancer patients with disseminated tumor cells
Presenter: Katherine Anne Lawson-Michod
Date & Time: April 21, 2026, 2:30–4:30 p.m.
Combating T Cell Checkpoints
Presentation: Transcriptional adaptation among highly essential paralogs contributes to genetic robustness of cancer genomes
Presenter: Siobhan O'Brien
Date & Time: April 21, 2026, 2:00–5:00 p.m.
Late-Breaking Research: Bioinformatics, Computational Biology, Systems Biology, and Convergent Science 2
Presentation: Multi-omic reconstruction of metastatic prostate cancer evolution from rapid autopsy reveals polyclonal seeding and implications for liquid biopsy
Presenter: Azhar Khandekar
Date & Time: April 22, 2026, 9:00 a.m.–12:00 noon
Cutting-Edge Advances in Hematology
Presentation: Targeting sialylation promotes anti-tumor immunity in small cell lung cancer
Presenter: Alex Doan
Date & Time: April 22, 2026, 9:00 a.m.–12:00 noon
Poster Presentations
For a list of Fred Hutch poster presentations at AACR, contact media@fredhutch.org.
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